[2026 update] Distinguishing expected GI effects from something that needs urgent attention

On the subject in the title: Distinguishing expected GI effects from something that needs urgent attention Working notes rather than a conclusion.

Reporting something rather than asking about it, in case the pattern is useful to anyone else.

Over 20 weeks I logged this consistently: date, dose, time of day, and a simple severity score from 0 to 4 for each symptom. That is 82 data points, all self-reported, all unblinded, and collected by someone who knew what he expected to find. Treat it accordingly.

The reason I am posting is that my experience does not match the shape people usually describe here, and I would like to know whether that is unusual or whether the usual description is just the loudest version.

Discontinuation for adverse effects in the published trials was not rare at the higher doses. That number belongs in any discussion of tolerability and is usually left out.

That has held every time I have looked, which is not the same as always.

Taking post #2 at face value and following it one step further.

Reflux and eructation are the two most under-reported effects in the first-hand accounts here, and both follow directly from delayed emptying.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.

Same conclusion as the reply above, reached differently, which is mildly reassuring.

Worth separating two things that post #11 runs together.

The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.