The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Evidence · Study critique · continued

A critique that turned out to be unfair, retracted by its author posts 31–39

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

EH
e.halonenTL215 Jul 2026#31

Criticism is more useful when it is narrower. "The trial answers a different question from the one being asked" is actionable; "the trial is flawed" is not.

That is the shape of it. The detail is where I would expect to be corrected.

8 likes 13d
DH
dietitian_hollisTL3Dietitian17 Jul 2026#32

The pre-specified endpoint being a weaker proxy than you would like is a real criticism. It is a smaller one than saying the result was chosen after the fact.

Not a strong opinion, just a consistent one.

2 likes 11d
NC
n.cabreraTL218 Jul 2026#33
titration_diary, post #18: Building on post #17 rather than restating it. Two questions I would want answered before drawing anything from the critique data above: how were the cases selected, and what happened to the ones that dropped out. Go to post

I had read the opposite somewhere and cannot now find where, which tells me something.

0 likes in reply to #18 10d
JW
journalclub_wrenTL3Regular20 Jul 2026#34

Picking up post #31: that is the part I would want checked first.

Marking my uncertainty on critique explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past the case in the first post.

19 likes 8d
SV
s.vukovicTL221 Jul 2026#35

Practical answer on critique, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the complicated explanation is needed. It usually is not.

12 likes 7d
SS
steady_stateTL3Regular23 Jul 2026#36

The strongest critiques cite the section they rely on. A critique without a page reference is an impression, however well informed.

If anyone can point at the primary source I would be grateful.

4 likes 5d
CC
c.castellanosTL224 Jul 2026#37

Worth separating two things that post #35 runs together.

The version of critique that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.

0 likes 4d
NE
n.ekstromTL2Regular26 Jul 2026#38

This follows post #35 rather than contradicting it.

Two people in this thread mean different things by critique and are disagreeing about the definition while believing they are disagreeing about the facts. Worth pausing to define it.

26 likes 2d
GA
g.amankwahTL227 Jul 2026#39
journalclub_wren, post #34: Picking up post #31: that is the part I would want checked first. Marking my uncertainty on critique explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past the case in the first post. Go to post

I had written a reply contradicting post #35 and deleted it. Here is what survived.

A critique should end with what would change your mind. Without that it is a position rather than an argument.

2 likes in reply to #34 17h

Suggested topics

TopicParticipantsRepliesViewsActivity
Reverse causation in a cohort study of weight and outcome — a second dataset
Reverse causation in a cohort study of weight and outcome — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Reverse causation. It…
MRAKANKBVK+112 131 1.5k 10mo
A well-designed study with a badly written abstract — does this still hold?
A well-designed study with a badly written abstract — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about well-designed study on behalf…
ENCEKA 2 28k 20mo
Selection into a registry and what it does to the estimate
Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Working notes on selection rather than a conclusion. I would rather post the…
SSLMAA 2 55k 7mo
Coming back to: A structured critique template this community uses
Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Reading back through what has been written here about structured…
SOFAKHASMY+63 69 17k 18h
Coming back to: Measurement error in a self-reported exposure
Measurement error in a self-reported exposure — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Measurement error, three questions…
LARNOAKACD+23 27 49k 3mo

Related topics — sharing the tags confounding, risk of bias, effect size

TopicParticipantsRepliesViewsActivity
Selection into a registry and what it does to the estimate
Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Working notes on selection rather than a conclusion. I would rather post the…
SSLMAA 2 55k 7mo
Follow-up: Journal club: the retatrutide phase 2 obesity paper
On the subject in the title: Journal club: the retatrutide phase 2 obesity paper Working notes rather than a conclusion. A follow-up question about retatrutide phase 2 obesity paper that I did not know to ask…
NDNRRRSIS+20 24 8.7k 16mo
What would change my mind about repair peptides: a specific answer — one year on
What would change my mind about repair peptides: a specific answer — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. Documentation question rather than a…
CTLLFVON+9 13 42k 19mo
Whether an aggregate is worth publishing at all: a disputed topic — does this still hold?
Whether an aggregate is worth publishing at all: a disputed topic — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. An honest uncertainty about…
BDHFBWIBOF+14 18 3.4k 2mo
Tracking a preprint to publication: a worked example
Tracking a preprint to publication: a worked example Writing it up because I had to work it out twice and would rather nobody else did. A preprint question rather than a question about the finding in it. The…
VBUCRSDTSB+133 147 15k 7mo