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Devices · Syringes & needles · continued

A ten-fold dose error caught before injection posts 91–104

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

IN
i.norgaardTL230 Aug 2025#91
dr_okonkwo, post #16: Drawing air into the vial before withdrawing liquid equalises the pressure and makes the draw easier. It is not required and it is why some people find a full vial harder to draw from than a half-empty one. A weak preference rather than a position. Go to post

The reason ten-fold dose error caught is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent.

9 likes in reply to #16 11mo
IT
impurity_tableTL3Analytical chemist1 Sep 2025#92

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

21 likes 11mo
JP
j.petrovTL23 Sep 2025 · edited#93

Post #92 is right about the mechanism and I think understates the practical bit.

Reusing a needle blunts it and there is no benefit to offset that. The second injection with the same needle is the one people describe as painful.

0 likes 11mo
CR
compounding_ruthTL4Pharmacist4 Sep 2025#94

Coming back to post #90, because the follow-up matters more than the original answer.

Silicone coating on the barrel affects how smoothly the plunger moves and how a very slow injection feels. It is one reason two syringes at the same specification are not identical to use.

I would rather be precise about what I do not know than vague about what I do.

1 like 11mo
DF
d.ferreiraTL26 Sep 2025#95
h.jansen, post #7: Coming back to post #3, because the follow-up matters more than the original answer. The most useful thing anyone has posted about ten-fold dose error caught in this category was a table of what had been measured and by whom. That is what I would want again. Go to post

Reusing a needle blunts it and there is no benefit to offset that. The second injection with the same needle is the one people describe as painful.

Reporting the observation and leaving the explanation open deliberately.

14 likes in reply to #7 11mo
B
batchlogTL3Regular8 Sep 2025#96

Clear enough that I do not think I have a follow-up, which is unusual.

29 likes 11mo
IA
id.almeidaTL29 Sep 2025#97

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

0 likes 11mo
BV
bias_varianceTL4Biostatistician11 Sep 2025#98
desiccant_notes, post #82: That is a cleaner way of putting what I was circling around. Go to post

I had written a reply contradicting post #94 and deleted it. Here is what survived.

Drawing air into the vial before withdrawing liquid equalises the pressure and makes the draw easier. It is not required and it is why some people find a full vial harder to draw from than a half-empty one.

2 likes in reply to #82 11mo
GR
g.radichTL213 Sep 2025#99
JR
j.rasmussenTL2Regular15 Sep 2025 · edited#100
Lundqvist, post #19: Marking my place. If it changes for me I will come back and say so. Go to post

Graduation spacing is worth checking before you buy rather than after. Some 1 mL barrels are marked every two units and some every one, and that changes what doses you can read.

I am reporting what happened, not recommending it.

0 likes in reply to #19 10mo
SC
s.coelhoTL216 Sep 2025#101

Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error.

The evidence for this is thinner than the way I have phrased it suggests.

0 likes 10mo
JM
j.mwangiTL4 Moderator18 Sep 2025#102

Syringe barrel size: common sizes are 0.3 mL, 0.5 mL, and 1.0 mL. Smaller barrels are more legible for small doses. Larger barrels hold larger volumes. Choose based on your dose.

It is the sort of thing that seems obvious in retrospect and was not at the time.

3 likes 10mo
JS
j.sorensenTL220 Sep 2025#103
r.ilunga, post #24: Ten-fold dose error caught would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator. Go to post

What I would tell a new member reading about ten-fold dose error caught for the first time: the confident posts are not the reliable ones, and the reliable ones are longer.

16 likes in reply to #24 10mo
JC
j.castellanosTL221 Sep 2025#104
b.fonseca, post #47: Insulin syringe graduations: U-100 syringes are marked in units where 100 units = 1 mL. Always confirm your syringe is U-100. Confusion between insulin units and milligrams is the most common syringe error. Go to post

On post #100 — agreed on the reasoning, with one qualification.

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

32 likes in reply to #47 10mo
This topic was closed 90 days after the last reply. Closing is automatic for quiet topics so that a settled answer does not collect new questions underneath it. If you have a follow-up, open a new topic and link back to this one — that keeps both readable and gives your question its own title.
Moved from Cold chain by t.vasquez. Category placement is not obvious from outside and getting it wrong is expected. This topic will get better answers here. The move is recorded in the public log citing R7.

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