Topic summary

A widely repeated interaction claim that turns out to be unsupported

Practice › Interactions metformin hypoglycaemia delayed gastric emptying needs a source

This is a generated summary. It shows the 7 most-liked posts from a topic of 52, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

c.silvaTL224 Nov 2025 · edited#7

b.fonseca, post #6: Worth separating two things that post #4 runs together. SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of concern. Go to post

Insulin and sulfonylureas are the interaction that the labelling in this class flags most explicitly, because the risk is additive glucose lowering. That is a prescribing question and not a forum question.

The disagreement above is smaller than it looks once the terms are fixed.

30 likes in reply to #6 8mo

r.ilungaTL210 Jan 2026#18

buffer_sheet, post #13: On post #11 — agreed on the reasoning, with one qualification. Oral medications with a narrow therapeutic index are the ones where that matters most. The interaction is about rate and timing rather than about the total absorbed, in most published cases. It cost nothing to check and would have cost something not to. Go to post

Anyone asking an interaction question should list everything, including the things they consider irrelevant. The irrelevant one is the answer more often than chance would suggest.

28 likes in reply to #13 7mo

t.vasquezTL4 Moderator25 Jan 2026#22

Post #18 put the caveat in the right place and I want to underline it.

Having read the whole widely repeated interaction claim thread before replying: the question in the first post has not actually been answered yet, and three of us have answered a nearby one instead.

26 likes 6mo

o.cousineauTL3Regular19 Feb 2026#29

Renal or hepatic impairment changes the calculus for a lot of combinations and is the context most often missing from an interaction question here.

25 likes 5mo

bac_waterTL2Regular8 Mar 2026#34

A pharmacist can answer most questions in this subcategory in a few minutes with access to a proper interaction database, and that access is the thing a forum does not have.

The mechanism is plausible, which is not the same as established.

25 likes 5mo

KAnderssonTL3Regular21 Mar 2026#38

33 likes 4mo

r.jhannsdttirTL3Regular3 Apr 2026#42

Widely repeated interaction claim is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.

24 likes 4mo

Read the full topic (52 posts)

This topic was referenced in

Levothyroxine timing: a real interaction with a simple fixPractice › Interactions · 24 replies

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