This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
Where I part company with post #90, and it is a narrow parting.
Adding a reference point for anaesthesia and elective surgery. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately.
Adding thanks rather than a view. I do not have a view worth the space.
A pharmacist can answer most questions in this subcategory in a few minutes with access to a proper interaction database, and that access is the thing a forum does not have.
The confident version of this sentence would be wrong, so here is the hedged one.
Confirming post #93 from a second method, which matters more than confirming it from a second person.
I would call the community position on anaesthesia and elective surgery likely rather than established, and I would be comfortable defending that hedge.
Anticoagulant questions come up regularly and are the clearest case for professional advice rather than discussion, because the consequence of being wrong is not gradual.
The answer changed when I changed how I was measuring, which was informative.
Where a published interaction study exists it usually reports an area-under-curve ratio, and that number is far more informative than a yes-or-no answer.
The mechanism is plausible, which is not the same as established.
Since anaesthesia and elective surgery keeps coming up, it should probably be a maintained page rather than a recurring thread. I am happy to draft it if someone with more direct experience will review it.
Renal or hepatic impairment changes the calculus for a lot of combinations and is the context most often missing from an interaction question here.
I have three months of notes on anaesthesia and elective surgery and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight.
Where I part company with post #101, and it is a narrow parting.
Second-hand on anaesthesia and elective surgery, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.
Post #101 is the version of this I will quote in future. One addition.
The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been studied, and where it has not, say that rather than filling the gap.
The literature is thinner on this than the confidence in the thread implies.
Practical experience of anaesthesia and elective surgery, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.
Reading rather than contributing, but this is the most useful thread I have found on it.
I had written a reply contradicting post #105 and deleted it. Here is what survived.
I would be cautious about generalising from the anaesthesia and elective surgery example above. It is a good example. It is one example.
My position on anaesthesia and elective surgery is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.
This follows post #109 rather than contradicting it.
A note on how anaesthesia and elective surgery gets discussed rather than on anaesthesia and elective surgery itself: the confident posts get the replies and the careful ones get ignored, and the careful ones have been right more often.
The arithmetic in post #108 is right; the assumption feeding it is the part to check.
A supplement is a drug for interaction purposes, and the fact that it is sold without a prescription tells you nothing about whether it interacts. The paperwork is usually worse rather than better.
Marking my place. If it changes for me I will come back and say so.
An update on my earlier anaesthesia and elective surgery post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.
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