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Research Methods · N-of-1 designs · continued

Blinding yourself: practical methods and their limits posts 31–45

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

YR
y.ramosTL24 Jun 2026#31

I had read the opposite somewhere and cannot now find where, which tells me something.

2 likes 2mo
ID
integrator_draftTL3Regular8 Jun 2026#32

My experience of blinding yourself contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.

0 likes 2mo
PF
p.friskTL211 Jun 2026#33
j.steiner, post #17: Blinding yourself is a good example of a question where the honest answer is boring and the interesting answers are unsupported. I would go with boring. Go to post

Blinding yourself is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.

26 likes in reply to #17 2mo
VM
v.milanoviTL3Regular15 Jun 2026#34
KTurkington, post #10: Worth separating two things that post #8 runs together. One caution on blinding yourself: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated. Go to post

This follows post #33 rather than contradicting it.

Blinding: blinding yourself (not knowing which condition you are in) removes expectation bias. This is hard to do with these compounds (the appetite suppression is hard to miss) but partial blinding is possible (measuring something objective without knowing whether you took it today).

12 likes in reply to #10 1mo
LF
l.ferreiraTL218 Jun 2026 · edited#35

I had written a reply contradicting post #33 and deleted it. Here is what survived.

Committing to post the result before you know it is a useful precommitment, and this subcategory is a reasonable place to make it.

4 likes 1mo
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GDashwoodTL3Regular22 Jun 2026#36

Confirming post #33 from a second method, which matters more than confirming it from a second person.

I would put moderate confidence on the mainstream reading of blinding yourself and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.

0 likes 1mo
SS
s.solbergTL226 Jun 2026#37

Nobody has said the unglamorous part of blinding yourself yet, so: most of the variation is explained by things that are boring to write about and easy to check.

0 likes 1mo
VK
v.klausenTL3Regular29 Jun 2026#38
s.leclerc, post #7: The thing about blinding yourself that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result. Go to post

It does not tell you about anybody else, which is why aggregating these accounts does not produce evidence of the kind people want it to.

That holds for the case as described. Change the assumptions and it may not.

18 likes in reply to #7 29d
KB
ka.batistaTL22 Jul 2026#39
s.leclerc, post #7: The thing about blinding yourself that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result. Go to post

Confounding in personal experiments: other things change when you start a medication (season, exercise, diet, stress). Documenting those confounders helps you understand their contribution to the result.

I would be interested in a counterexample if anyone has one.

7 likes in reply to #7 25d
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FairweatherTL2Member6 Jul 2026#40

Understood, and I withdraw the assumption I opened with.

1 like 22d
MR
m.restrepoTL29 Jul 2026 · edited#41

Post #38 answers the question as asked. The question underneath it is different.

Blinding yourself is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.

4 likes 19d
LO
l.oseiTL213 Jul 2026#42
c.rasmussen, post #3: The arithmetic in post #2 is right; the assumption feeding it is the part to check. Nothing in a personal experiment is medical advice to anyone including yourself, and several people here have found that a prescriber will happily discuss a well-documented one. Go to post

I read post #41 twice before replying, because I had assumed the opposite.

Trying to state the blinding yourself position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.

12 likes in reply to #3 15d
JS
j.silvaTL216 Jul 2026#43

Blinding yourself is harder than it sounds and is not impossible. Somebody else preparing labelled containers is the usual approach and it requires a second person you trust.

0 likes 12d
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ThibodeauTL3Regular20 Jul 2026#44

A rolling mean over several days is far more informative than any single reading for anything that varies day to day, which is nearly everything.

0 likes 8d
PM
p.marchettiTL223 Jul 2026#45

Narrowing post #42, because the general version has more than one answer.

Distinguishing three things in the blinding yourself discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the recommendation that gets attached to both.

1 like 5d

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