m.restrepo

TL2 · Cork

Contributes reviews on supplier material. Based in Cork.

Joined 26 September 2025 · last posted 2d

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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #98 · Practice › Dosing & titration · 26 Jul 2026 · 18 likes Stepping down deliberately: the withdrawal trials show that stopping is followed by regain. The step-down literature is thinner. The conservative assumption is that…
What the GIP component of tirzepatide is thought to contribute, and how confident we can… Replied, post #18 · Compounds › Tirzepatide · 25 Jul 2026 · 2 likes Everything in post #16 holds. The case it does not cover is the one I have. Titration schedules for tirzepatide have more dose steps than semaglutide partly because the…
Common supplements people ask about, assessed one at a time Replied, post #57 · Practice › Interactions · 17 Jul 2026 · 0 likes What I would check first on common supplements is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
Blinding yourself: practical methods and their limits Replied, post #41 · Research Methods › N-of-1 designs · 9 Jul 2026 · 4 likes Post #38 answers the question as asked. The question underneath it is different. Blinding yourself is worth one more sentence than it usually gets, and the sentence is…
What I would want from a home test that does not exist yet Replied, post #32 · Analytics › Home & field testing · 9 Jul 2026 · 18 likes Post #28 put the caveat in the right place and I want to underline it. Ultraviolet absorbance at 280 nanometres estimates concentration for peptides containing aromatic…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #33 · Evidence › Journal club · 7 Jul 2026 · 22 likes Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later. The…
Tracking a shortage from primary sources rather than rumour Replied, post #87 · Access › Shortages · 6 Jul 2026 · 27 likes Post #85 put the caveat in the right place and I want to underline it. Reading this tracking a shortage thread as someone who came in with a fixed view: the third and…
[2026 update] Second opinions: how to seek one without burning the first Replied, post #2 · marked as the solution · Clinical › Prescriber conversations · 3 Jul 2026 · 14 likes Worth separating two things that the opening post runs together. Take the actual numbers and the actual dates. A printed table beats a description and takes the first…
Prescription requirements and telehealth models — a second dataset Replied, post #70 · Sourcing › Regulatory · 18 Jun 2026 · 11 likes On post #66 — agreed on the reasoning, with one qualification. Agreed on Prescription requirements and telehealth models, with one qualification that I think matters.…
Pooling trials with different estimands Replied, post #8 · Evidence › Meta-analyses · 5 Jun 2026 · 7 likes Overlapping populations across included trials inflate the apparent sample size. It happens more than people expect where the same programme reports multiple papers.…
Second pass at: When your prescriber and the evidence disagree Replied, post #29 · Clinical › Prescriber conversations · 31 May 2026 · 3 likes Clarifying indication: if a compound is approved for diabetes but you have obesity without diabetes, clarify whether your clinician considers this off-label use and…
Follow-up: Sleep quality changes during weight loss Replied, post #16 · Wellbeing › Sleep · 5 May 2026 · 15 likes Right, and stated more narrowly than I would have dared to state it.