A critique should end with what would change your mind. Without that it is a position rather than an argument.
It is a small point and it changes the answer, which is an awkward combination.
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
A critique should end with what would change your mind. Without that it is a position rather than an argument.
It is a small point and it changes the answer, which is an awkward combination.
What I would check first on structured critique template is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
Filing a mild objection to the consensus on structured critique template. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.
I had written a reply contradicting post #60 and deleted it. Here is what survived.
The pre-specified endpoint being a weaker proxy than you would like is a real criticism. It is a smaller one than saying the result was chosen after the fact.
When you change your mind: if a reply convinces you that your criticism was not well-founded, say so plainly. The critique might still be real but smaller than you originally thought. That is not a failure — it is how discussion works.
Where I part company with post #64, and it is a narrow parting.
Practical experience of structured critique template, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.
Whatever the answer on structured critique template turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite the correction.
Everything in post #68 holds. The case it does not cover is the one I have.
Surrogate endpoints are not automatically bad and their validity is compound-specific and population-specific. The question is whether this surrogate has been validated for this use.
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