Dose numbers for oral formulations are not comparable to injectable ones

On the subject in the title: Dose numbers for oral formulations are not comparable to injectable ones Working notes rather than a conclusion.

Putting the numbers in the first post, because a question about a compound without them turns into a question about somebody's impression of it.

oral semaglutide, monoisotopic mass near 4113.6 Da, 14 weeks of my own notes, and 5 lots from 2 suppliers with a purity figure on each. That is the whole basis of what follows.

What I want checked is the reasoning I have built on top of it, not the figures themselves.

Taking post #11 at face value and following it one step further.

Tablet integrity matters more than people expect for a formulation that depends on an absorption enhancer released at a particular place. Splitting or crushing is not a dose adjustment; it is a different product.

That is a description of practice, not a recommendation of it.

I had read the opposite somewhere and cannot now find where, which tells me something.

Post #15 describes the usual case. This is about the unusual one.

SNAC is the sodium N-(8-[2-hydroxybenzoyl]amino) caprylate, an absorption enhancer that transiently raises local pH in the stomach and promotes gastric mucosal absorption. Without it, oral bioavailability of semaglutide would be too low for clinically useful dosing.

It is worth checking rather than assuming, which costs nothing.

Research-use-only oral material is not a licensed tablet and there is no reason to assume it carries a functioning absorption-enhancement system at all. The formulation is most of the product here.

Two people can read the same figure differently here and both be reasonable.