Half-life, steady state, and accumulation worked through — a second dataset

This is the answer, and the reason it is the answer is the more useful part.

Adding a note of thanks rather than an opinion. I did not know most of that.

Post #23 put the caveat in the right place and I want to underline it.

Trying to state the Half-life position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.

Reframing Half-life slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes. If it is "how often", nobody here knows.

Adding what did not work for me on Half-life, since the failures never get written up and they are half the useful information.

That matches what I have seen, for whatever a single anecdote is worth.

The accumulation ratio for weekly dosing with a week-long half-life is around two, which is why the concentration after several doses is roughly double the concentration after the first.

I would hold that lightly until someone with a larger sample weighs in.

My understanding of Half-life is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.

Where two sources give different half-lives, check the study design before deciding either is wrong. Sampling duration, assay sensitivity and population all move the number.

That distinction has done more work for me than anything else in this category.