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Access · Shortages · continued

Second pass at: Hoarding and why it makes a shortage worse posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

MH
ms_hollowayTL4Mass spectrometrist10 Oct 2024#31

This follows post #28 rather than contradicting it.

Both are useful and different. The notice tells you the national position; the account tells you what is happening on the ground.

17 likes 22mo
EI
e.iyerTL210 Oct 2024#32
OB
owen.bradyTL4 Moderator10 Oct 2024#33

I came in to disagree and I am leaving without a disagreement.

0 likes 22mo
NS
n.silvaTL210 Oct 2024#34
TL4_Halvorsen, post #13: Post #10 is the version of this I will quote in future. One addition. Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage). Small point, but it is the one that usually… Go to post

Where a shortage forces a gap, the pharmacokinetics mean a missed week is a perturbation rather than a reset, which is worth knowing.

Adding it because I spent an afternoon working it out and nobody should have to twice.

4 likes in reply to #13 22mo
SC
sourced_claimsTL3Regular10 Oct 2024#35
chromatogram, post #17: Manufacturer allocation decisions during a shortage are commercial and are rarely explained, which is frustrating and is not evidence of anything. A modest claim, modestly supported. Go to post

Taking post #34 at face value and following it one step further.

Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated.

For what it is worth, the same held on the two occasions I checked.

24 likes in reply to #17 22mo
RB
r.bruunTL210 Oct 2024#36

Post #34 and I disagree about the size of the effect, not about the direction.

Switching presentation or strength during a shortage is a prescribing decision rather than a substitution anybody should improvise.

0 likes 22mo
DV
dr.villanuevaTL3Physician10 Oct 2024#37

Both are useful and different. The notice tells you the national position; the account tells you what is happening on the ground.

1 like 22mo
SG
s.grimaldiTL210 Oct 2024#38
endo_fellow_rk, post #11: The published shortage register maintained by the national regulator is the authoritative source here, and it is updated far more often than any thread. Go to post

Compounding during shortages: some jurisdictions allow pharmacy compounding when a marketed product is in shortage. That permission is jurisdiction-specific and time-limited (usually for the duration of the shortage).

Happy to expand any of that if it is the useful part.

7 likes in reply to #11 22mo
SC
s.chowdhuryTL310 Oct 2024#39
AA
a.adeyemiTL210 Oct 2024#40

No notes. Posting so the count is not one.

18 likes 22mo
HS
hana.satoTL4 Moderator10 Oct 2024#41
c.amankwah, post #21: Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your clinician is prudent if the gap is weeks or longer. The conclusion is tentative; the arithmetic underneath it is not. Go to post

Anyone reporting availability should say the region and the date, because both determine whether the report is usable.

I have no interest in any supplier named above.

28 likes in reply to #21 22mo
FA
f.amankwahTL210 Oct 2024 · edited#42
j.vogel, post #12: Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated. Go to post

Picking up post #41: that is the part I would want checked first.

Shortage-driven price movement is real and is a separate question from availability.

The general answer and the answer for your case may diverge here.

14 likes in reply to #12 22mo
EP
e.piresTL210 Oct 2024#43

Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are different decisions.

2 likes 22mo
AK
a.kowalskiTL210 Oct 2024#44

Manufacturer allocation decisions during a shortage are commercial and are rarely explained, which is frustrating and is not evidence of anything.

The interesting part of this is the exception, and I do not understand the exception.

0 likes 22mo
BI
blank_injectionTL2Analytical chemist10 Oct 2024#45
endo_fellow_rk, post #28: Pharmacy-level availability varies enormously during a shortage, so two honest accounts from the same city can be opposite. I would rather say I do not know than round it up to an answer. Go to post

Post #43 describes the usual case. This is about the unusual one.

A shortage of one presentation is not a shortage of all of them, and the published notices are specific about which.

If that reads as pedantic, it is, and it has saved me twice.

0 likes in reply to #28 22mo
HB
h.bakkerTL210 Oct 2024#46

Useful. I had the fact and not the reason, which turns out to be the important half.

20 likes 22mo
MS
m.strand_rphTL3Pharmacist10 Oct 2024#47

Reports that a pharmacy has stock are the least durable information on the site and are still worth posting with a date.

A qualification I should have led with rather than closed on.

5 likes 22mo
CO
c.ostergaardTL210 Oct 2024#48

Stockpiling in response to a shortage worsens it, which is true and is a poor argument to make to somebody who has run out.

The rule of thumb is fine; the edge cases are where it earns its keep.

0 likes 22mo
QZ
q.zhao_qaTL3Quality assurance10 Oct 2024#49

Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.

14 likes 22mo
SA
s.antonsenTL210 Oct 2024#50
c.niemel, post #4: Taking the opening post at face value and following it one step further. Regional differences during a shortage are large, and a supply position in one country says nothing about another. I would want a second opinion before relying on that. Go to post

Supply interruptions: official shortage notices are published by regulatory agencies. That is the correct primary source rather than pharmacy rumors or forum discussion.

5 likes in reply to #4 22mo
MD
m.dumitruTL211 Oct 2024#51

The arithmetic in post #50 is right; the assumption feeding it is the part to check.

Where an alternative within the class is available, the comparison is a clinical one and the doses are not equivalent.

I would want the raw data before agreeing with my own summary of it.

15 likes 22mo
Z
ZieglerTL3Regular11 Oct 2024#52

Both are useful and different. The notice tells you the national position; the account tells you what is happening on the ground.

If anyone has run this properly I would rather read that than my own guess.

30 likes 22mo
BJ
b.jansenTL211 Oct 2024#53

Planning around a known shortage window is easier than reacting to one, and the notices give advance warning more often than people expect.

1 like 22mo
BP
baseline_peakTL2Member11 Oct 2024#54
chromatogram, post #17: Manufacturer allocation decisions during a shortage are commercial and are rarely explained, which is frustrating and is not evidence of anything. A modest claim, modestly supported. Go to post

Post #52 put the caveat in the right place and I want to underline it.

The published shortage register maintained by the national regulator is the authoritative source here, and it is updated far more often than any thread.

One more caveat and then I will stop qualifying: the sample selected itself.

6 likes in reply to #17 22mo
BN
b.nwosuTL211 Oct 2024 · edited#55
hana.sato, post #41: Anyone reporting availability should say the region and the date, because both determine whether the report is usable. I have no interest in any supplier named above. Go to post

Anyone reporting availability should say the region and the date, because both determine whether the report is usable.

10 likes in reply to #41 22mo
MS
m.stephanopoulosTL3Regular11 Oct 2024#56

Shortage status determines what compounding is permitted in some jurisdictions, which links two questions that otherwise seem unrelated.

23 likes 22mo
NN
n.norgaardTL211 Oct 2024#57

I will take the caveat as seriously as the claim, which is the point of putting it there.

0 likes 22mo
RG
r.girardTL211 Oct 2024#58

Where I part company with post #56, and it is a narrow parting.

Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are different decisions.

Written in the hope of being told what I have missed.

3 likes 22mo
CS
c.silvaTL211 Oct 2024#59

Stockpiling in response to a shortage worsens it, which is true and is a poor argument to make to somebody who has run out.

6 likes 22mo
AZ
a.zamoraTL211 Oct 2024#60

Noted, and thank you for writing it out rather than summarising it.

16 likes 22mo