Posting this under the heading it deserves: Second pass at: Temperature logging at home: what is worth the effort Everything below is what sits behind that.
Posting a small dataset on Temperature logging. It is mine, it is uncontrolled, and the method is stated so it can be discounted appropriately.
What I would like is not agreement but a second dataset collected by someone with no stake in mine. If one exists I would rather read it than argue for this one.
Answering the question the opening post raises rather than the one it answers.
The honest summary: keep it dry until you need it, keep it cold once it is not, keep it dark, do not cycle the temperature, and treat any period at room temperature as spent whether or not anything visible happened.
Building on the opening post rather than restating it.
Published stability data applies specifically to the formulation studied, under the specific conditions stated. It does not automatically transfer to something reconstituted at home in a different concentration with a different diluent. That caveat is not small.
Useful. I have added it to my own notes with the date on it.
Narrowing post #3, because the general version has more than one answer.
A beyond-use date on a home preparation is an inference rather than a measurement. It can be a reasonable inference and it should be described as one.
Everything in post #2 holds. The case it does not cover is the one I have.
Temperature excursions in transit are common and are not all equal. A few hours warm is a different event from three days warm, and neither is visible in the vial on arrival.
I would put a moderate confidence on that and no more.
Cold-chain arrival condition is worth recording even when everything is fine, because the record is only useful if it contains the ordinary cases as well as the bad ones.
The reasoning is more useful than the number, which is why I have shown it.
Reconstituted material carried in a bag for a day is a temperature excursion even in a cool climate. Where that matters is cumulative exposure over weeks rather than a single afternoon.
That is the honest state of it as of this week.
Refrigeration slows degradation. Repeated warming and cooling is worse than continuous refrigeration. Light exposure is worth avoiding. The concentration matters because adsorptive losses are proportionally larger in dilute solutions. All of that is reasonably well supported.
The mechanism is plausible, which is not the same as established.
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