Sulfonylureas: the interaction most worth taking seriously Writing it up because I had to work it out twice and would rather nobody else did.
An honest uncertainty about sulfonylureas rather than a disguised assertion.
I do not know the answer and I have not been able to find one. What I have is the shape of the question, which may be worth more than my guess at the answer.
Supplements and herbs: many have no established interaction. Some do. If you are taking something unusual, checking a reference (like a pharmacist) is more useful than guessing from forum discussion.
I would not lead a decision with this, but I would not ignore it either.
Absence of an interaction study is not evidence of no interaction. A great many combinations discussed here have simply never been studied, and saying so is more useful than reasoning from mechanism alone.
Correct me on the arithmetic if it is wrong; I would rather know.
Building on post #5 rather than restating it.
Alcohol is not contraindicated in the labelling and it does irritate a stomach that is already emptying slowly. There is no published interaction study, and the conservative reading is the obvious one.
I would call that likely rather than established.
Insulin and sulfonylureas are the interaction that the labelling in this class flags most explicitly, because the risk is additive glucose lowering. That is a prescribing question and not a forum question.
Oral medications with a narrow therapeutic index are the ones where that matters most. The interaction is about rate and timing rather than about the total absorbed, in most published cases.
If the premise is wrong, everything after it is decoration.
A pharmacist can answer most questions in this subcategory in a few minutes with access to a proper interaction database, and that access is the thing a forum does not have.
It cost nothing to check and would have cost something not to.
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Alcohol: what is documented and what is folklore — the long version
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Reading an interaction checker output critically
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+144 | 152 | 3k | 4mo |
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Follow-up: Reading an interaction checker output critically
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Metformin co-administration and additive GI effects
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Alcohol: what is documented and what is folklore
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+110 | 116 | 43k | 14mo |
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Levothyroxine timing: a real interaction with a simple fix
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+20 | 24 | 60k | 18mo |
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+7 | 11 | 26k | 4mo |
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A widely repeated interaction claim that turns out to be unsupported
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+47 | 51 | 37k | 3mo |
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