Cagrisema phase 2 paper looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
30 likes 17mo
Topic summary
The CagriSema phase 2 paper and what a fixed combination buys
This is a generated summary. It shows the 9 most-liked posts from a topic of 94, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
Where I have landed on cagrisema phase 2 paper, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise magnitude has borrowed it from somewhere that did not measure it.
25 likes 16mo
a.zamora, post #23: Confirming post #22 from a second method, which matters more than confirming it from a second person. The question underneath cagrisema phase 2 paper is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it. Write down what you would expect to see under each hypothesis before you collect… Go to post
The phase 3 combination programme is where the clinically interesting numbers will come from. Phase 2 established that the combination does something; the size of it in a larger population is a separate question.
On post #53 — agreed on the reasoning, with one qualification.
Worth distinguishing the combination product from the two components bought separately and mixed. Those are different pharmaceutical objects and nothing published about the first applies to the second.
Worth saying I have only my own numbers here, and n is small.
29 likes 13mo
Amylin signalling is distinct from GLP-1 signalling. Amylin slows gastric emptying and promotes satiety through a different receptor and different neural pathways. The hypothesis behind combination is two complementary satiety mechanisms with one injection.
29 likes 13mo
h.bakker, post #39: Helpful, and easy to find again, which is half of what a good reply is. Go to post
Adding the measurement that post #66 says would settle it.
Cagrilintide alone is discussed less than in combination because the published data is almost entirely from combination trials. The phase 2 combination data was consistent with more effect than either component alone, but phase 2 cannot establish whether that is synergy or simply additivity.
m.coelho, post #46: Distinguishing three things in the cagrisema phase 2 paper discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the recommendation that gets attached to both. Go to post
Post #67 and I disagree about the size of the effect, not about the direction.
Cagrilintide alone is discussed less than in combination because the published data is almost entirely from combination trials. The phase 2 combination data was consistent with more effect than either component alone, but phase 2 cannot establish whether that is synergy or simply additivity.
A guess, clearly labelled as one.
Second-hand on cagrisema phase 2 paper, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.
31 likes 12mo
Read the full topic (94 posts)
Suggested topics
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
The CagriSema phase 2 paper and what a fixed combination buys — the long version
The CagriSema phase 2 paper and what a fixed combination buys — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about CagriSema phase 2…
|
+137 | 158 | 17k | 13mo |
|
Nausea profile of amylin analogues compared with GLP-1 agonists
Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin nausea profile of…
|
+70 | 76 | 3k | 4mo |
|
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins
Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. A question about Amylin and gastric emptying that I think has a…
|
+21 | 25 | 44k | 5mo |
|
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1
On the subject in the title: Amylin analogue mechanism: satiety signalling separate from GLP-1 Working notes rather than a conclusion. Trying to work out what would count as evidence on Amylin analogue…
|
+27 | 31 | 671 | 12mo |
|
Historical amylin analogues and what happened to them
Posting this under the heading it deserves: Historical amylin analogues and what happened to them Everything below is what sits behind that. Proposing that historical amylin analogues deserves a maintained…
|
+29 | 36 | 31k | 1d |
Related topics — sharing the tags randomised trial, cagrilintide, effect size
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
The most common factual error about semaglutide on the internet — what changed since
The most common factual error about semaglutide on the internet — what changed since — setting out what I have, and where I think it stops being reliable. Putting the numbers in the first post, because a…
|
+42 | 46 | 1.7k | 5mo |
|
Regression to the mean in progress reports
On the subject in the title: Regression to the mean in progress reports Working notes rather than a conclusion. Something about regression does not reconcile and I would like a second pair of eyes before I…
|
+30 | 34 | 49k | 12mo |
|
Criticising the method without criticising the authors — one year on
On the subject in the title: Criticising the method without criticising the authors — one year on Working notes rather than a conclusion. A methods question rather than a substantive one, about Criticising…
|
+16 | 20 | 61k | 11mo |
|
Comparing my trajectory with the trial curves, carefully
Posting this under the heading it deserves: Comparing my trajectory with the trial curves, carefully Everything below is what sits behind that. Maintenance rather than loss, which is the part of this that…
|
+86 | 92 | 54k | 7mo |
|
The CagriSema phase 2 paper and what a fixed combination buys — the long version
The CagriSema phase 2 paper and what a fixed combination buys — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about CagriSema phase 2…
|
+137 | 158 | 17k | 13mo |