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Evidence · Preprints · continued

Tracking a preprint to publication: a worked example posts 91–120

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

NL
ne.laurentTL29 Dec 2025#91
n.serrano, post #55: Narrowing post #54, because the general version has more than one answer. Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Happy to be the one who is wrong here if it settles the question. Go to post

This follows post #90 rather than contradicting it.

Reading a preprint properly means doing some of the reviewer's job: methods first, then whether the analysis matches the plan, then the conclusion.

1 like in reply to #55 8mo
BR
buffer_reviewTL3Regular9 Dec 2025#92

Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight.

Small point, but it is the one that usually catches people.

6 likes 8mo
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a.norgaardTL29 Dec 2025#93

That is a fair summary of where the discussion has got to.

22 likes 8mo
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trough_indexTL3Regular9 Dec 2025#94

Coming back to post #92, because the follow-up matters more than the original answer.

Retractions and corrections do not propagate well from preprint servers. A citation that was fine when made can quietly become wrong.

0 likes 8mo
AK
ak.kravchenkoTL29 Dec 2025#95

Picking up post #94: that is the part I would want checked first.

Two people in this thread mean different things by tracking a preprint and are disagreeing about the definition while believing they are disagreeing about the facts. Worth pausing to define it.

3 likes 8mo
AD
ambient_draftTL3Regular9 Dec 2025 · edited#96

On post #92 — agreed on the reasoning, with one qualification.

Where a preprint's numbers are the basis of a claim being repeated here, someone should check whether the published version exists yet. That check is nearly always overdue.

10 likes 8mo
MA
mi.amankwahTL210 Dec 2025#97

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

Worth one more sentence than it usually gets.

29 likes 8mo
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LJankowiakTL3Regular10 Dec 2025#98
ar.petrov, post #17: This follows post #14 rather than contradicting it. What I would check first on tracking a preprint is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph. Go to post

Version numbers on a preprint server matter. Citing version one of something now on version four is citing a document that has been superseded by its own authors.

I have deliberately not rounded that, because the rounding is where the argument starts.

0 likes in reply to #17 8mo
AF
a.friskTL210 Dec 2025#99

Peer review catches some things reliably — missing methods, unsupported conclusions, statistical mistakes of the obvious kind — and misses others routinely. Knowing which is which makes preprint reading easier.

It is a small point and it changes the answer, which is an awkward combination.

0 likes 8mo
PM
p.mbekiTL210 Dec 2025#100

Post #96 put the caveat in the right place and I want to underline it.

If someone has run tracking a preprint properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.

1 like 8mo
NG
np_gilmoreTL3Nurse practitioner10 Dec 2025#101
NHuddleston, post #10: Post #9 is the version of this I will quote in future. One addition. I think the tracking a preprint question is answerable and has not been answered, which is a more optimistic position than most of this thread. Go to post

A preprint with the data and code attached is frequently more checkable than a published paper without them. Reviewed and reproducible are different properties.

4 likes in reply to #10 8mo
RM
r.mensaTL210 Dec 2025#102
r.coelho, post #32: Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published, your reasoning based on the preprint needs to be revised. Posting it because the silence on this was starting to look like agreement. Go to post

Post #98 and I disagree about the size of the effect, not about the direction.

Building anything durable on a preprint means committing to rebuild it. That is a reasonable trade for a fast-moving question and it should be an explicit one.

12 likes in reply to #32 8mo
MD
m.dalgaardTL3Regular10 Dec 2025#103

Post #100 answers the question as asked. The question underneath it is different.

Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful.

Two sources, same conclusion, and I could not rule out that one copied the other.

25 likes 8mo
AJ
a.jansenTL210 Dec 2025 · edited#104

Peer review as a filter: published papers have survived a review process that rejects many submissions. Preprints have not. Neither guarantees correctness, but publication history is a difference worth noting.

It cost nothing to check and would have cost something not to.

0 likes 8mo
RA
r.aldana_pharmdTL4Pharmacist10 Dec 2025#105
m.dalgaard, post #103: Post #100 answers the question as asked. The question underneath it is different. Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Two sources, same conclusion, and I could not rule out that one copied the other. Go to post

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

This is the sort of thing that ought to be settled and apparently is not.

7 likes in reply to #103 8mo
RZ
r.zielinskiTL210 Dec 2025#106
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peak_purityTL3Analytical chemist11 Dec 2025#107

Narrowing post #104, because the general version has more than one answer.

For anyone finding this later: the short answer on tracking a preprint is that it depends on one thing, and the rest of the thread is people identifying which thing.

0 likes 8mo
NS
no.silvaTL211 Dec 2025#108

Everything in post #107 holds. The case it does not cover is the one I have.

Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the stronger citation if it exists.

0 likes 8mo
DS
d.szymanskiTL3Wiki editor11 Dec 2025#109
KStephanopoulos, post #33: Post #32 is the version of this I will quote in future. One addition. Tracking a preprint is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says which one is being asked for. Go to post

Screening on a preprint server is minimal and is not review. It filters obvious problems and nothing more, which is what it is designed to do.

Anyone who has looked at this more carefully, please correct the record.

11 likes in reply to #33 8mo
EN
e.ndiayeTL211 Dec 2025#110

If you cite a preprint in a maintained document here, the convention is to label it in the sentence and to note the check date. The document review will catch the update.

I would be interested in a counterexample if anyone has one.

24 likes 8mo
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l.parkinsonTL211 Dec 2025#111
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ma.nascimentoTL211 Dec 2025#112

Seconded. It reads as careful rather than confident, which is the right register.

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citation_peakTL3Regular11 Dec 2025#113

A preprint that has been up for two years without appearing in a journal is telling you something, and it is not necessarily that the work is bad.

6 likes 8mo
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f.yildizTL211 Dec 2025#114
h.ferrari, post #22: Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Go to post

Narrowing post #113, because the general version has more than one answer.

Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.

It is worth checking rather than assuming, which costs nothing.

1 like in reply to #22 8mo
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WendelboeTL2Member11 Dec 2025#115
tracked_parcel, post #8: On tracking a preprint, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the interesting bit. If you can post the two or three numbers you are working from, several people here will check the arithmetic rather than argue about the conclusion. Go to post

Posting my tracking a preprint numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

0 likes in reply to #8 8mo
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z.szaboTL211 Dec 2025#116

Version numbers on a preprint server matter. Citing version one of something now on version four is citing a document that has been superseded by its own authors.

22 likes 8mo
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eire_readerTL2Regional · IE12 Dec 2025#117

I read post #113 twice before replying, because I had assumed the opposite.

Building anything durable on a preprint means committing to rebuild it. That is a reasonable trade for a fast-moving question and it should be an explicit one.

Not disagreeing with anyone above, just adding the bit I keep having to look up.

10 likes 8mo
FH
f.haddadTL212 Dec 2025#118

Post #117 answers the question as asked. The question underneath it is different.

A preprint with the data and code attached is frequently more checkable than a published paper without them. Reviewed and reproducible are different properties.

Posted with less confidence than the sentence structure implies.

3 likes 8mo
LA
l.aaltonenTL3Regular12 Dec 2025 · edited#119
e.lehtinen, post #21: Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere. Citing the preprint with its DOI is appropriate while noting it is unpublished. Go to post

This settles it for me, at least until somebody posts a reason it should not.

0 likes in reply to #21 8mo
PO
p.onwukaTL212 Dec 2025#120

This follows post #117 rather than contradicting it.

I have been on both sides of the tracking a preprint argument in this category within eighteen months, which should tell you how strong the evidence for either side is.

30 likes 8mo