v.bergstrom

TL2 · Rennes

Contributes reviews on supplier material. Based in Rennes.

Joined 21 July 2025 · last posted 2d

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Programming during a large energy deficit Replied, post #50 · Nutrition & Training › Resistance training · 26 Jul 2026 · 7 likes Where training is new, the early gains are largely neural, which is why they can appear even during a deficit and do not indicate tissue change. That is one dataset and…
Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #29 · Compounds › Cagrilintide & amylin analogues · 22 Jul 2026 · 5 likes Narrowing post #26, because the general version has more than one answer. For anyone arriving from searches on "amylin agonist": this subcategory discusses published…
Revisiting: Protein density versus volume when you cannot eat much Replied, post #91 · Nutrition & Training › Protein & intake · 22 Jul 2026 · 0 likes Fibre and fluid tend to fall alongside protein when intake drops, and the constipation reported here follows from that as much as from the mechanism.
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #92 · Evidence › Journal club · 9 Jul 2026 · 32 likes On SURMOUNT-OSA I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads…
Revisiting: What pooling buys you and what it destroys Replied, post #83 · Evidence › Meta-analyses · 8 Jul 2026 · 18 likes Taking post #82 at face value and following it one step further. Where the included trials share a sponsor and a protocol template, their errors correlate and pooling…
[2026 update] Journal club: what we got wrong in an earlier session Replied, post #4 · Evidence › Journal club · 1 Jul 2026 · 0 likes Picking up post #2: that is the part I would want checked first. A session that ends with a list of what remains unresolved is more useful than one that ends with a…
Why side effects reset at each escalation and that is not a failure Replied, post #3 · Practice › Side effects · 1 Jul 2026 · 17 likes Gastrointestinal effects in this class are dose-related and escalation-related. Both are true simultaneously, which is why symptoms typically return at each step and…
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #47 · Sourcing › Independent verification · 27 Jun 2026 · 3 likes Useful. I had the fact and not the reason, which turns out to be the important half.
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #29 · Analytics › Impurities & related substances · 27 Jun 2026 · 0 likes Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue. Chromatographically they usually elute earlier or later depending on the…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #19 · Practice › Dosing & titration · 26 Jun 2026 · 2 likes Stepping down deliberately: the withdrawal trials show that stopping is followed by regain. The step-down literature is thinner. The conservative assumption is that…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #60 · Compounds › Oral incretins · 26 Jun 2026 · 10 likes Worth separating two things that post #56 runs together. The absorption enhancer in the licensed oral product works by transiently raising local gastric pH and…
Second pass at: Programming during a large energy deficit Replied, post #33 · Nutrition & Training › Resistance training · 18 Jun 2026 · 0 likes Recovery capacity falls with energy availability, so a programme that worked at maintenance may be too much during a large deficit. On balance I think that is right,…