Freeze-thaw and why one cycle is not the same as five

The arithmetic in post #2 is right; the assumption feeding it is the part to check.

Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.

I would put this at better than even and not much better.

Small methodological point on freeze-thaw: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.

Worth separating two things that post #8 runs together.

The honest summary: keep it dry until you need it, keep it cold once it is not, keep it dark, do not cycle the temperature, and treat any period at room temperature as spent whether or not anything visible happened.

This is the sort of thing the wiki should carry and currently does not.

A supplier stability statement tied to a named storage condition can be evaluated. One that says "store cool" cannot, and the difference between those two documents is larger than it looks.

Anyone with a larger sample, please post it.

Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.