Intersection · Pharmacology × tirzepatide

Pharmacology topics tagged tirzepatide

Topics in Pharmacology carrying the tag tirzepatide. Dual GIP and GLP-1 receptor agonist.

23 topics

Topic	Participants	Replies	Views	Activity
Receptor desensitisation as a tolerance hypothesis, and its weak evidence tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on receptor…	+52	57	25k	just now
GLP-1 receptor distribution: central and peripheral semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. I have spent a fortnight trying to pin GLP-1 receptor distribution…	+90	98	30k	22h
Peak-to-trough ratio at steady state for a weekly agent — the long version semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Peak-to-trough ratio,…	+57	61	708	1d
About the Receptor biology category amylin analogues semaglutide tirzepatide Pinned Wiki GLP-1, GIP, glucagon and amylin receptor signalling, bias, desensitisation and central versus peripheral action. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit…	+6	10	34k	20d
Peak-to-trough ratio at steady state for a weekly agent tirzepatide liraglutide worked example missed dose Solved On the subject in the title: Peak-to-trough ratio at steady state for a weekly agent Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the…	+58	64	9.7k	2mo
Clearance pathways and what renal impairment changes missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of clearance pathways is wrong? I…	+11	15	43k	2mo
Amylin receptor signalling and satiety — what changed since tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of Amylin receptor signalling and satiety…	+73	78	3.5k	2mo
Coming back to: Half-life, steady state, and accumulation worked through tirzepatide liraglutide worked example semaglutide On the subject in the title: Half-life, steady state, and accumulation worked through Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the…	+14	18	15k	3mo
Follow-up: Glucagon receptor agonism in a weight-loss compound amylin analogues long read tirzepatide retatrutide Glucagon receptor agonism in a weight-loss compound Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Glucagon receptor agonism that I did not know…	+5	9	21k	7mo
Revisiting: GLP-1 receptor distribution: central and peripheral amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+61	66	15k	8mo
About the Pharmacokinetics category semaglutide tirzepatide liraglutide Pinned Wiki Half-life, accumulation, steady state, albumin binding, and why weekly dosing works. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	32k	8mo
Follow-up: Why appetite effects are mostly central tirzepatide retatrutide semaglutide long read Closed Asking directly, because I could not find a straight answer: Why appetite effects are mostly central A follow-up question about appetite effects that I did not know to ask the first time. The earlier thread…	+86	90	61k	9mo
Amylin receptor signalling and satiety tirzepatide semaglutide amylin analogues Wiki Amylin receptor signalling and satiety Writing it up because I had to work it out twice and would rather nobody else did. Asking about amylin receptor signalling and satiety directly, because I have read four…	+22	26	1.8k	9mo
GIP receptor agonism and the argument about direction tirzepatide long read amylin analogues semaglutide GIP receptor agonism and the argument about direction — setting out what I have, and where I think it stops being reliable. A question about GIP receptor agonism that I think has a definite answer, unlike…		2	867	10mo
Vagal afferents and the gut-brain pathway — one year on amylin analogues long read semaglutide retatrutide Vagal afferents and the gut-brain pathway — one year on Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about Vagal afferents rather than a disguised…		2	136	11mo
Vagal afferents and the gut-brain pathway semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. Vagal afferents — I have the observation and I do not trust my interpretation of it, so I am…	+5	9	44k	13mo
Half-life, steady state, and accumulation worked through semaglutide liraglutide tirzepatide Wiki Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I…	+115	130	44k	13mo
Albumin binding and how it produces a long half-life semaglutide liraglutide worked example tirzepatide Albumin binding and how it produces a long half-life — setting out what I have, and where I think it stops being reliable. A narrow question about albumin binding, deliberately narrow, because the broad…	+38	44	6.6k	14mo
Why appetite effects are mostly central amylin analogues tirzepatide semaglutide long read Why appetite effects are mostly central I have a specific reason for asking rather than idle curiosity, and the context is below. Appetite effects: what I expected, what I found, and the gap between them. I…		2	56k	16mo
Biased agonism: a real phenomenon, an over-used explanation semaglutide retatrutide long read tirzepatide Posting this under the heading it deserves: Biased agonism: a real phenomenon, an over-used explanation Everything below is what sits behind that. Trying to work out what would count as evidence on biased…	+130	135	23k	16mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Biased agonism is…	+49	56	47k	17mo
Glucagon receptor agonism in a weight-loss compound semaglutide retatrutide tirzepatide Pinned On the subject in the title: Glucagon receptor agonism in a weight-loss compound Working notes rather than a conclusion. Glucagon receptor agonism: setting out the arithmetic in full, because I have had to do…		2	5.1k	20mo
Time to steady state after a dose increase tirzepatide liraglutide worked example missed dose On the subject in the title: Time to steady state after a dose increase Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the confusion here is…	+151	163	9.7k	21mo

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