Ranked by engagement

Top topics — this month page 4

Ranked by replies, likes and views over this month, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

374 topics · page 4 of 13

Topic	Participants	Replies	Views	Activity
Micro-titration: a disputed topic, argued properly — one year on Practice › Dosing & titration dose reduction missed dose semaglutide Posting this under the heading it deserves: Micro-titration: a disputed topic, argued properly — one year on Everything below is what sits behind that. Reading back through what has been written here about…	+63	68	35k	1d
Prescription requirements and telehealth models — a second dataset Sourcing › Regulatory compounding EMA MHRA personal import On the subject in the title: Prescription requirements and telehealth models — a second dataset Working notes rather than a conclusion. Posting a small dataset on Prescription requirements and telehealth…	+87	94	1.1k	21d
Pinch or no pinch, and how needle length changes the answer — what changed since Practice › Administration missed dose aseptic technique injection site rotation Solved Posting this under the heading it deserves: Pinch or no pinch, and how needle length changes the answer — what changed since Everything below is what sits behind that. What changes if the standard account of…	+58	62	16k	1d
Does a peptide degrade silently, with no visual change? Practice › Storage & stability beyond-use date cold chain temperature excursion freeze-thaw Solved Does a peptide degrade silently, with no visual change? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of peptide is wrong? I…	+73	79	1.3k	1d
Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides needs a source BPC-157 preprint Solved Why the absence of controlled human data on BPC-157 matters more than people admit — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to know what people…	+60	66	16k	1d
Follow-up: Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+62	67	12k	9h
A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipid panel HbA1c liver enzymes lipase & amylase Posting this under the heading it deserves: A single out-of-range value on an otherwise normal panel Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+70	75	20k	6d
Search filters: what is missing Meta › Site feedback site feedback moderation guidelines Search filters: what is missing — setting out what I have, and where I think it stops being reliable. Search filters — I have the observation and I do not trust my interpretation of it, so I am posting the…	+72	84	15k	3d
Prior authorisation: what the criteria usually require — a second dataset Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Prior authorisation: what the criteria usually require — a second dataset Everything below is what sits behind that. Posting a small dataset on Prior authorisation.…	+67	74	19k	21h
Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration aseptic technique subcutaneous injection missed dose needle gauge & length Wiki Posting this under the heading it deserves: Completing a dose with a second syringe, and the dead-volume arithmetic Everything below is what sits behind that. I have read the maintained page on this and I…	+65	76	7.4k	1d
Insomnia at a dose step: reported experiences — the long version Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Solved Pinned Insomnia at a dose step: reported experiences — the long version Writing it up because I had to work it out twice and would rather nobody else did. A sleep question with what I actually recorded rather than…	+47	51	31k	1d
How much context is too much context in a first post? Start Here › How to Ask guidelines beginner friendly onboarding site feedback Solved How much context is too much context in a first post? I have a specific reason for asking rather than idle curiosity, and the context is below. Counting it rather than describing it, because the count is the…	+69	74	935	18d
Electrolyte supplements: which ones do anything Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue Solved On the subject in the title: Electrolyte supplements: which ones do anything Working notes rather than a conclusion. A hydration and intake question, with the figures, since this one is unanswerable without…	+47	51	31k	18d
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Programming during a large energy: what I expected, what I found, and the gap between them. I am…	+39	49	36k	2d
Why fasting instructions for oral semaglutide are not optional advice Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Solved Why fasting instructions for oral semaglutide are not optional advice I have a specific reason for asking rather than idle curiosity, and the context is below. Fasting instructions for oral semaglutide, from…	+70	74	1.1k	23d
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…	+70	76	4.8k	15h
Bioimpedance and hydration: why the number moves Outcomes › Body composition lean mass loss data table DXA bioimpedance Bioimpedance and hydration: why the number moves — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin bioimpedance and hydration down and I want to set…	+62	70	13k	23d
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+63	74	11k	1d
A 10 mg vial reconstituted three different ways, compared Practice › Reconstitution bacteriostatic water worked example concentration maths Posting this under the heading it deserves: A 10 mg vial reconstituted three different ways, compared Everything below is what sits behind that. Something about 10 mg vial reconstituted three does not…	+30	34	55k	17h
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on PCOS and metabolic…	+55	59	26k	2d
Follow-up: How compounding permissions changed when supply normalised Sourcing › Regulatory MHRA personal import research use only How compounding permissions changed when supply normalised I have a specific reason for asking rather than idle curiosity, and the context is below. I was wrong about compounding permissions in a thread last…	+72	77	1.5k	1d
Coming back to: A structured critique template this community uses Evidence › Study critique confounding risk of bias disputed observational data Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Reading back through what has been written here about structured…	+63	69	17k	18h
What to include when your question involves a chromatogram — one year on Start Here › How to Ask worked example guidelines site feedback onboarding Asking directly, because I could not find a straight answer: What to include when your question involves a chromatogram — one year on Question in the title. Context below, and I have tried to include the…	+69	75	862	14d
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC HPLC system suitability gradient method Detection wavelength and why 214 nm and 280 nm disagree — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on Detection wavelength,…	+69	76	920	6h
The headache that turns out to be dehydration — the long version Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate Under review On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. A narrow question about headache, deliberately narrow, because the broad…	+68	73	1.3k	12h
Does dual agonism explain the effect size, or is it dose? Compounds › Tirzepatide SURPASS programme SURMOUNT programme tirzepatide randomised trial Solved Does dual agonism explain the effect size, or is it dose? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about dual agonism that I think has a definite…	+62	68	2.6k	29d
Pancreatitis history and the risk calculus Safety › Contraindications delayed gastric emptying thyroid C-cell question pancreatitis pregnancy & planning Solved Posting this under the heading it deserves: Pancreatitis history and the risk calculus Everything below is what sits behind that. I would like to know what people here actually do about pancreatitis history,…	+28	32	52k	17h
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on receptor…	+52	57	25k	just now
Angle of injection and whether 90 degrees is always right — the long version Practice › Administration injection site reaction needle gauge & length injection site rotation missed dose Pinned Angle of injection and whether 90 degrees is always right — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Angle of injection,…	+50	55	15k	2d
Blinding yourself: practical methods and their limits Research Methods › N-of-1 designs confounding data table effect size On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. A methods question rather than a substantive one, about blinding yourself. Everyone…	+40	44	33k	5d