Ranked by engagement

Top topics — this week

Ranked by replies, likes and views over this week, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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314 topics · page 1 of 11

Topic	Participants	Replies	Views	Activity
[2026 update] Regional warehouse stock versus direct despatch Sourcing › Logistics packaging customs shipping cold chain Regional warehouse stock versus direct despatch Writing it up because I had to work it out twice and would rather nobody else did. Working notes on Regional warehouse stock versus direct rather than a…	+135	147	32k	2d
[2026 update] Interpreting a result that disagrees with the supplier's certificate Sourcing › Independent verification Medutest VendorInvestigate blind sampling third-party testing Solved On the subject in the title: Interpreting a result that disagrees with the supplier's certificate Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+121	128	51k	17h
What consumer-accessible tests can and cannot determine — a second dataset Analytics › Home & field testing ELISA LOD & LOQ third-party testing documentation quality Solved What consumer-accessible tests can and cannot determine — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. Posting a small dataset on…	+117	131	45k	10h
Seven-day rolling means and why weekly readings mislead Outcomes › Progress reports data table DXA effect size long read Seven-day rolling means and why weekly readings mislead Writing it up because I had to work it out twice and would rather nobody else did. Posting a series rather than a conclusion, with the method first.…	+109	125	42k	10h
Micro-titration: a disputed topic, argued properly Practice › Dosing & titration titration dose reduction worked example tirzepatide Solved Wiki Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on…	+99	110	61k	2d
Revisiting: The report format the maintainers ask for, and why each field is there Sourcing › Vendor reports batch & lot numbers Janoshik Analytical documentation quality third-party testing Posting this under the heading it deserves: Revisiting: The report format the maintainers ask for, and why each field is there Everything below is what sits behind that. Structured report rather than an…	+100	108	57k	1d
Alcohol: what is documented and what is folklore Practice › Interactions metformin insulin delayed gastric emptying Posting this under the heading it deserves: Alcohol: what is documented and what is folklore Everything below is what sits behind that. Alcohol, and specifically the version of it that the documentation does…	+120	134	11k	2d
Tracking a shortage from primary sources rather than rumour Access › Shortages shortage FDA formulary Tracking a shortage from primary sources rather than rumour — setting out what I have, and where I think it stops being reliable. An honest uncertainty about tracking a shortage rather than a disguised…	+121	126	35k	13h
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Practice › Reconstitution syringe units worked example reconstitution bacteriostatic water Solved A 5 mg vial and a 0.25 mg dose: the arithmetic in full Writing it up because I had to work it out twice and would rather nobody else did. 5 mg vial: setting out the arithmetic in full, because I have had to…	+124	141	16k	2d
Insurance and replacement policies, compared Sourcing › Logistics temperature excursion cold chain customs shipping Solved On the subject in the title: Insurance and replacement policies, compared Working notes rather than a conclusion. I have spent a fortnight trying to pin insurance and replacement policies down and I want to…	+115	122	17k	17h
Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club journal club estimand randomised trial Journal club: orforglipron phase 2 and the non-peptide question Writing it up because I had to work it out twice and would rather nobody else did. Orforglipron phase 2, and specifically the version of it that…	+120	132	13k	1d
Reading a home test result without over-claiming Analytics › Home & field testing ELISA documentation quality LOD & LOQ third-party testing Reading a home test result without over-claiming — setting out what I have, and where I think it stops being reliable. Collecting what is known about reading a home test result in one place, because it is…	+124	137	19k	7h
What a certificate commits its issuer to Analytics › COA interpretation reference standards batch & lot numbers amino acid analysis The question in the title: What a certificate commits its issuer to I will give what I have already checked below so nobody repeats it. A documentation question rather than an analytical one. I have a…	+101	116	26k	19h
Journal club: SUSTAIN 6 and its retinopathy signal Evidence › Journal club estimand effect size risk of bias journal club Under review On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…	+110	122	46k	1d
Journal club: what we got wrong in an earlier session Evidence › Journal club number needed to treat effect size randomised trial journal club On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Bringing a claim rather than a paper, because the claim is the thing circulating. The…	+114	125	2.5k	23h
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how this site should cite something…	+109	116	36k	2d
Revisiting: The best-written scientific paper you have read Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: Revisiting: The best-written scientific paper you have read Everything below is what sits behind that. Asking about best-written scientific paper directly, because…	+102	121	21k	1h
Request: a per-category review queue Meta › Feature requests site feedback translation wiki post Request: a per-category review queue Writing it up because I had to work it out twice and would rather nobody else did. Per-category review queue — I have the observation and I do not trust my interpretation…	+121	136	13k	2h
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. A comparison question rather than a question about one…	+83	91	46k	1d
Spreadsheets: an appreciation — what changed since Lounge › Off topic long read beginner friendly Spreadsheets: an appreciation — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Spreadsheets is wrong? I ask because I have…	+102	113	26k	17h
Submitting a sample: the process end to end Sourcing › Independent verification blind sampling PeptideMeter VendorInvestigate third-party testing On the subject in the title: Submitting a sample: the process end to end Working notes rather than a conclusion. Submitting a sample keeps being re-asked here and I think that is because the answer is…	+99	114	29k	21h
I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome guidelines onboarding trust levels Posting this under the heading it deserves: I joined for one answer and stayed for a year — what changed my mind Everything below is what sits behind that. Question in the title and the context underneath, in…	+95	114	17k	just now
Trust level 3 requirements: a clarification — does this still hold? Meta › Announcements trust levels moderation site feedback guidelines Solved Asking directly, because I could not find a straight answer: Trust level 3 requirements: a clarification — does this still hold? Two things I would like separated before anyone answers on Trust level 3…	+77	90	57k	9h
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I think the…	+104	110	16k	2d
Pooling trials with different estimands Evidence › Meta-analyses publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Asking about pooling trials with different estimands on behalf of the question I keep seeing asked…	+120	132	2.3k	1d
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Collecting what is known about forced degradation studies…	+100	106	35k	2d
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Compounds › Semaglutide STEP programme type 2 diabetes randomised trial SELECT trial Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. Semaglutide and gastric emptying,…	+115	122	2.6k	1d
Common supplements people ask about, assessed one at a time Practice › Interactions insulin needs a source hypoglycaemia metformin Common supplements people ask about, assessed one at a time — setting out what I have, and where I think it stops being reliable. A follow-up question about common supplements that I did not know to ask the…	+101	107	28k	12h
A site rotation scheme that is easy enough to actually follow Practice › Administration needle gauge & length missed dose injection site rotation aseptic technique On the subject in the title: A site rotation scheme that is easy enough to actually follow Working notes rather than a conclusion. Two things I would like separated before anyone answers on site rotation…	+112	125	5.8k	21h
Lean mass preservation: what the evidence supports — does this still hold? Outcomes › Body composition bioimpedance lean mass loss data table DXA Asking directly, because I could not find a straight answer: Lean mass preservation: what the evidence supports — does this still hold? What changes if the standard account of Lean mass preservation is wrong?…	+112	122	5.2k	20h

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