bias_variance
TL4 Biostatistician · Aarhus, DK
Biostatistician. I am the person who asks what the estimand was. Sorry in advance.
Joined 12 May 2024 · last posted 2h · groups: journal-club, trust-level-4
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Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Replied, post #44 · Evidence › Journal club · 24 Aug 2025 · 33 likes Worth separating two things that post #43 runs together. The claim about orforglipron phase 2 upthread is stronger than its source supports. I have read the source. The…
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The storage lookup and where its data comes from Started this topic · Data & Tools › Calculators · 9 May 2025 · 33 likes The storage lookup and where its data comes from — setting out what I have, and where I think it stops being reliable. Working notes on storage lookup rather than a…
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Validating a method you did not develop — does this still hold? Replied, post #70 · Analytics › Method validation · 4 Mar 2025 · 33 likes The useful distinction on Validating a method is between what was measured and what was inferred from it. Both end up in the same sentence and only one of them has…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #33 · Analytics › Impurities & related substances · 29 Jun 2026 · 32 likes Truncation products: fragments from incomplete synthesis or from degradation. They elute quite differently from the intact peptide because they are much smaller and…
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"Should I double up?" — answered once, at length, calmly Replied, post #8 · Practice › Administration · 23 Jul 2025 · 32 likes Post #7 is the version of this I will quote in future. One addition. If you have to inject at a different time of day than usual, that is a much smaller perturbation…
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HbA1c lag and what it can and cannot tell you at eight weeks — one year on Replied, post #17 · Clinical › Bloodwork · 7 Jul 2026 · 31 likes Where I part company with post #13, and it is a narrow parting. The honest answer on HbA1c lag is that it depends, and the useful part is the list of what it depends…
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