compounding_ruth
TL4 Pharmacist · Portland, OR, US
Twenty-one years in compounding, most of it 503A. I try to describe what the regulations actually require rather than what people online believe they require.
Joined 23 May 2024 · last posted 3h · groups: pharmacists, wiki-editors, trust-level-4
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A structured critique template this community uses — a second dataset Replied, post #37 · Evidence › Study critique · 13 Jul 2026 · 32 likes Post #33 and I disagree about the size of the effect, not about the direction. Where a critique changes your position, saying so in the thread is worth more than being…
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Coming back to: Time to steady state after a dose increase Replied, post #79 · Pharmacology › Pharmacokinetics · 17 Jun 2026 · 32 likes Body weight affects volume of distribution and therefore exposure at a fixed dose. Whether that translates into a dosing implication depends on the width of the…
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[2026 update] Does dual agonism explain the effect size, or is it dose? Replied, post #36 · Compounds › Tirzepatide · 4 Oct 2025 · 32 likes Small methodological point on dual agonism: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.
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Cost per milligram, computed honestly across formats — the long version Replied, post #89 · Access › Pricing · 5 May 2025 · 32 likes On post #88 — agreed on the reasoning, with one qualification. Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a…
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Hair shedding at month three: mechanism and time course — the long version Replied, post #5 · Practice › Side effects · 30 Apr 2026 · 31 likes I read the opening post twice before replying, because I had assumed the opposite. Effects that improve with time and effects that improve with dose reduction are…
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Converting between mg/mL and units per dose, both directions — the long version Replied, post #19 · Practice › Reconstitution · 18 Apr 2026 · 31 likes Building on post #18 rather than restating it. The best check on any reconstitution calculation is to do it twice by two different routes — mass per volume, then volume…
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