s.grahame
TL2 Member · Quebec City, CA
Practical questions, practical answers. Not interested in speculation without a source.
Joined 14 December 2024 · last posted 3d
83Posts here
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Comparators chosen for regulatory reasons rather than clinical ones — one year on Started this topic · Evidence › Trials · 22 Mar 2025 · 39 likes Comparators chosen for regulatory reasons rather than clinical ones — one year on — setting out what I have, and where I think it stops being reliable. Posting a small…
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Journal club: STEP 4 and what a withdrawal design can prove Replied, post #45 · Evidence › Journal club · 25 May 2025 · 32 likes Post #42 answers the question as asked. The question underneath it is different. The baseline characteristics table is the single most useful page for the questions…
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A supplier who responds to a discrepancy with silence — what changed since Replied, post #80 · Sourcing › Red flags · 13 Jul 2026 · 31 likes Supplier: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.
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What a documentation review can and cannot tell you Replied, post #6 · Sourcing › Independent verification · 15 Jun 2025 · 31 likes It does not extend to lots nobody has seen, it is not a recommendation, and it says nothing about anything other than what was measured. I have separated what I…
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About the COA interpretation category Replied, post #11 · Analytics › COA interpretation · 11 May 2026 · 28 likes I read post #7 twice before replying, because I had assumed the opposite. A chromatogram supplied as a small image is legible for peak shape and not for baseline…
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Revisiting: What pooling buys you and what it destroys Replied, post #69 · Evidence › Meta-analyses · 26 Jun 2026 · 26 likes When a meta-analysis is unhelpful: if the included studies are heterogeneous in population, intervention, or outcome, pooling them produces a number that represents…
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