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On the live site this tab tracks what you have not read. In this static rendering it shows every topic with activity in the last 45 days, which is the closest honest equivalent — we would rather explain the difference than pretend a static page knows your reading history.

414 topics · page 10 of 14

Topic	Participants	Replies	Views	Activity
What to include when your question involves a laboratory result Start Here › How to Ask beginner friendly site feedback guidelines Asking directly, because I could not find a straight answer: What to include when your question involves a laboratory result Question in the title. Context below, and I have tried to include the things people…	+8	12	14k	2d
Follow-up: The retatrutide phase 2 obesity paper, read closely Compounds › Retatrutide retatrutide randomised trial preprint effect size The retatrutide phase 2 obesity paper, read closely — setting out what I have, and where I think it stops being reliable. A follow-up question about retatrutide phase 2 obesity paper that I did not know to…	+19	23	16k	2d
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides observational data TB-500 BPC-157 preprint Solved Revisiting: Why the absence of controlled human data on BPC-157 matters more than people admit Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about…	+50	55	7.8k	2d
Micro-titration: a disputed topic, argued properly Practice › Dosing & titration titration dose reduction worked example tirzepatide Solved Wiki Micro-titration: a disputed topic, argued properly Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on…	+99	110	61k	2d
Alcohol: what is documented and what is folklore Practice › Interactions metformin insulin delayed gastric emptying Posting this under the heading it deserves: Alcohol: what is documented and what is folklore Everything below is what sits behind that. Alcohol, and specifically the version of it that the documentation does…	+120	134	11k	2d
What a certificate commits its issuer to — the long version Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards certificate of analysis Asking directly, because I could not find a straight answer: What a certificate commits its issuer to — the long version A documentation question rather than an analytical one. I have a certificate in front…	+20	26	21k	2d
Impurity thresholds: where the common numbers come from Analytics › Impurities & related substances water content data table forced degradation counter-ion content Impurity thresholds: where the common numbers come from — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin impurity thresholds down and I want to set…	+11	15	825	2d
Why chargeback is not the safety net people assume Sourcing › Payments research use only payments documentation quality Solved Asking directly, because I could not find a straight answer: Why chargeback is not the safety net people assume Asking about the record rather than the transfer. Every order leaves a trail: an order…	+22	26	2.5k	2d
Coming back to: Preparing for an appointment: one page, three questions Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes prior authorisation Preparing for an appointment: one page, three questions — setting out what I have, and where I think it stops being reliable. A question about how to describe something to a clinician rather than about the…	+51	56	1.4k	2d
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I think the…	+104	110	16k	2d
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback data table Solved Posting this under the heading it deserves: A community side-effect dataset, with its response rate and biases Everything below is what sits behind that. Community side-effect dataset — I have the observation…	+96	101	33k	2d
NHS criteria and how they are applied in practice Regional › UK & Ireland NHS cost per milligram personal import MHRA NHS criteria and how they are applied in practice — setting out what I have, and where I think it stops being reliable. I was wrong about NHS criteria in a thread last spring and I would like to correct it…	+37	42	31k	2d
Stepping down deliberately, and how to do it without losing progress — what changed since Practice › Dosing & titration tirzepatide semaglutide titration missed dose Under review Posting this under the heading it deserves: Stepping down deliberately, and how to do it without losing progress — what changed since Everything below is what sits behind that. Something changed and I would…	+94	99	29k	2d
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Collecting what is known about forced degradation studies…	+100	106	35k	2d
Designing a personal experiment that could change your mind — one year on Research Methods › N-of-1 designs effect size data table worked example Designing a personal experiment that could change your mind — one year on — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on…	+74	80	17k	2d
Why catalogue breadth is not evidence of anything Compounds › Other compounds research use only needs a source custom synthesis Under review Why catalogue breadth is not evidence of anything I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of catalogue breadth is wrong?…		2	38k	2d
[2026 update] Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC UV & DAD detection system suitability peak integration gradient method Solved Why 99.2% and 97.8% on the same lot can both be correct — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this number means before I…	+1	5	719	2d
[2026 update] A report I filed that turned out to be wrong, and the correction Sourcing › Vendor reports batch & lot numbers third-party testing documentation quality certificate of analysis On the subject in the title: A report I filed that turned out to be wrong, and the correction Working notes rather than a conclusion. Structured report rather than an opinion, following the format the…	+15	19	18k	2d
Batch numbers that do not match the vial label Sourcing › Red flags mislabelling disputed moderation underdosing Solved Batch numbers that do not match the vial label — setting out what I have, and where I think it stops being reliable. Structured question about turnaround and what it signals. I have started recording how long…	+43	48	8.9k	2d
Coming back to: Payment method and the leverage it gives you, ranked Sourcing › Payments payments documentation quality research use only Payment method and the leverage it gives you, ranked — setting out what I have, and where I think it stops being reliable. A payments question, with the mechanics separated from the money. What I would like…	+21	26	43k	2d
Second pass at: When your prescriber and the evidence disagree Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth prior authorisation Pinned Second pass at: When your prescriber and the evidence disagree — setting out what I have, and where I think it stops being reliable. What changes if the standard account of prescriber is wrong? I ask because…	+51	55	9.2k	2d
How shortages have affected compounding permissions Access › Shortages shortage compounding FDA formulary How shortages have affected compounding permissions I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what people here actually do about shortages,…	+61	71	3.6k	2d
Ultrasound and skinfolds: operator dependence in practice Outcomes › Body composition DXA data table lean mass loss Ultrasound and skinfolds: operator dependence in practice — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on ultrasound and skinfolds. The…	+72	76	2.7k	2d
Revisiting: Protein density versus volume when you cannot eat much Nutrition & Training › Protein & intake constipation micronutrients lean mass loss fatigue Revisiting: Protein density versus volume when you cannot eat much Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin Protein density…	+97	108	3.6k	2d
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Programming during a large energy: what I expected, what I found, and the gap between them. I am…	+39	49	36k	2d
Review: an evidence digest and the citation check that delayed it Documentation › Doc review citation check review date promoted to docs wiki post On the subject in the title: Review: an evidence digest and the citation check that delayed it Working notes rather than a conclusion. I was wrong about evidence digest in a thread last spring and I would…	+13	17	15k	2d
Follow-up: UK access routes, dated and sourced Regional › UK & Ireland personal import cost per milligram MHRA Solved On the subject in the title: UK access routes, dated and sourced Working notes rather than a conclusion. Regional question, dated March 2026, because everything in this category expires. The position differs…	+10	14	27k	2d
Why the timeline is on the right and not the left — what changed since Meta › Site feedback site feedback moderation guidelines Solved Why the timeline is on the right and not the left — what changed since I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of…	+77	81	4k	2d
About the Adverse events category Safety › Adverse events pancreatitis vomiting gallbladder Pinned Wiki Serious and unexpected events, how to document them, and where to report them officially. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…	+2	6	8.7k	2d
Why a glucagon receptor agonist in a weight-loss compound is not a contradiction Compounds › Retatrutide retatrutide preprint randomised trial effect size Solved The question in the title: Why a glucagon receptor agonist in a weight-loss compound is not a contradiction I will give what I have already checked below so nobody repeats it. I would like to disagree…	+43	47	19k	2d