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Evidence · Preprints · continued

Coming back to: Why a preprint's supplementary material is often the best part posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

QL
quiet_lurkerTL2Regular15 Apr 2026 · edited#31

Post #27 and I disagree about the size of the effect, not about the direction.

Retractions and corrections do not propagate well from preprint servers. A citation that was fine when made can quietly become wrong.

9 likes 3mo
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a.adeyemiTL217 Apr 2026#32

Taking post #31 at face value and following it one step further.

Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for understanding emerging evidence, not for drawing definitive conclusions.

I checked the source rather than the summary, and they differ.

2 likes 3mo
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asking_properlyTL1Member18 Apr 2026#33
l.dziedzic, post #24: Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one. One case, stated as one case. Go to post

How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.

Where I would look next, rather than where I would stop.

0 likes in reply to #24 3mo
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a.nybergTL219 Apr 2026#34
n.torrence, post #17: Helpful, and short, which on this subject is harder than long. Go to post

Reading a preprint properly means doing some of the reviewer's job: methods first, then whether the analysis matches the plan, then the conclusion.

It is the kind of thing that is obvious once and never again.

21 likes in reply to #17 3mo
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h.oyelowoTL221 Apr 2026#35
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r.bruunTL222 Apr 2026#36

This follows post #34 rather than contradicting it.

A preprint that has been up for two years without appearing in a journal is telling you something, and it is not necessarily that the work is bad.

1 like 3mo
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s.chowdhuryTL3Regular23 Apr 2026#37
k.roos, post #23: Server repositories: medRxiv for medicine, bioRxiv for biology. Preprints on these servers are time-stamped and have DOIs even if they are later published elsewhere. Citing the preprint with its DOI is appropriate while noting it is unpublished. Go to post

Thank you — that answers what I came here to find out.

30 likes in reply to #23 3mo
MR
m.radichTL225 Apr 2026#38

The honest position on most preprints in this field is that they are interesting and provisional, and that saying both is not fence-sitting.

The reasoning is more useful than the number, which is why I have shown it.

15 likes 3mo
DV
dr.villanuevaTL3Physician26 Apr 2026#39

Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.

Nothing above should be read as advice about what anyone else should do.

20 likes 3mo
EI
e.iyerTL227 Apr 2026#40

Post #39 is the version of this I will quote in future. One addition.

Version numbers on a preprint server matter. Citing version one of something now on version four is citing a document that has been superseded by its own authors.

That is all I can say without guessing.

9 likes 3mo
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f.fenwickTL3Regular29 Apr 2026#41

A preprint reporting a null result is more likely to stay a preprint, which biases the published literature and makes preprint servers more valuable rather than less.

Written from notes rather than memory, which is why the numbers are specific.

2 likes 3mo
LA
l.aguirreTL230 Apr 2026#42
Knowlton, post #30: Where a preprint's numbers are the basis of a claim being repeated here, someone should check whether the published version exists yet. That check is nearly always overdue. I would want a second opinion before relying on that. Go to post

Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for understanding emerging evidence, not for drawing definitive conclusions.

8 likes in reply to #30 3mo
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r.friskTL21 May 2026 · edited#43

Post #40 is the version of this I will quote in future. One addition.

Say it is a preprint in the first line rather than the last. Everything downstream depends on that status and readers arriving from search will not scroll for it.

If that reads as pedantic, it is, and it has saved me twice.

18 likes 3mo
HF
h.ferrariTL23 May 2026#44

Peer review catches some things reliably — missing methods, unsupported conclusions, statistical mistakes of the obvious kind — and misses others routinely. Knowing which is which makes preprint reading easier.

On reflection I would soften that slightly.

0 likes 3mo
RV
r.villalobosTL24 May 2026#45

If you cite a preprint in a maintained document here, the convention is to label it in the sentence and to note the check date. The document review will catch the update.

It is one reading of the data and not the only reasonable one.

0 likes 3mo
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r.danquahTL25 May 2026#46
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k.fonsecaTL27 May 2026#47
e.iyer, post #40: Post #39 is the version of this I will quote in future. One addition. Version numbers on a preprint server matter. Citing version one of something now on version four is citing a document that has been superseded by its own authors. That is all I can say without guessing. Go to post

Building on post #44 rather than restating it.

Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published, your reasoning based on the preprint needs to be revised.

13 likes in reply to #40 3mo
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k.vanheckeTL28 May 2026#48

That is consistent with mine, for whatever one more account is worth.

27 likes 3mo
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WoodhouseTL2Member9 May 2026#49
h.oyelowo, post #35: Worth separating two things that post #31 runs together. Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Go to post

Narrowing post #47, because the general version has more than one answer.

Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight.

0 likes in reply to #35 3mo
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z.vogelTL211 May 2026#50
k.fonseca, post #47: Building on post #44 rather than restating it. Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published, your reasoning based on the preprint needs to be revised. Go to post

Everything in post #47 holds. The case it does not cover is the one I have.

Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.

I looked this up rather than remembered it, which is the right order.

2 likes in reply to #47 3mo
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r.petrovTL212 May 2026#51

Retractions and corrections do not propagate well from preprint servers. A citation that was fine when made can quietly become wrong.

Not a strong opinion, just a consistent one.

0 likes 3mo
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ppm_errorTL3Analytical chemist13 May 2026#52

The honest position on most preprints in this field is that they are interesting and provisional, and that saying both is not fence-sitting.

If anyone has run this properly I would rather read that than my own guess.

0 likes 3mo
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b.vanheckeTL214 May 2026#53
Woodhouse, post #49: Narrowing post #47, because the general version has more than one answer. Sample size and pre-registration are checkable in a preprint exactly as in a paper, and they carry the same weight. Go to post

Author track record is a weak signal and it is a signal. A group that has published carefully for years is a different prior from an unknown one.

17 likes in reply to #49 2mo
MS
m.strand_rphTL3Pharmacist16 May 2026#54

Adding the measurement that post #53 says would settle it.

Check whether it was later published: searching for the preprint's first author and keywords in PubMed might find a published version. The published version is the stronger citation if it exists.

7 likes 2mo
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n.vukovicTL217 May 2026#55

I had written a reply contradicting post #53 and deleted it. Here is what survived.

Screening on a preprint server is minimal and is not review. It filters obvious problems and nothing more, which is what it is designed to do.

0 likes 2mo
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o.lindgrenTL2Regular18 May 2026 · edited#56

A preprint with the data and code attached is frequently more checkable than a published paper without them. Reviewed and reproducible are different properties.

25 likes 2mo
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n.cardosoTL219 May 2026#57
k.fonseca, post #47: Building on post #44 rather than restating it. Do not build anything on a preprint that you would mind rebuilding: if the preprint later changes substantially in revision or shows different results when published, your reasoning based on the preprint needs to be revised. Go to post

Where numbers change between preprint and published version, the changes are not random. They tend toward a smaller effect and a more carefully hedged claim.

Two people can read the same figure differently here and both be reasonable.

12 likes in reply to #47 2mo
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preregisteredTL3Research methods21 May 2026#58
h.oyelowo, post #35: Worth separating two things that post #31 runs together. Where a preprint contradicts a published trial, the prior should favour the trial. Where it extends one, the preprint can be genuinely useful. Go to post

That is a fair summary of where the discussion has got to.

4 likes in reply to #35 2mo
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n.stanescuTL222 May 2026#59

Coming back to post #57, because the follow-up matters more than the original answer.

What changes between preprint and publication: authors respond to reviewer comments, re-analyse data, correct errors found in peer review, and sometimes report different results from updated analyses. The published version is not the same as the preprint.

If the premise is wrong, everything after it is decoration.

0 likes 2mo
JN
j.nwosuTL223 May 2026#60

Post #57 is right about the mechanism and I think understates the practical bit.

Building anything durable on a preprint means committing to rebuild it. That is a reasonable trade for a fast-moving question and it should be an explicit one.

18 likes 2mo