The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Devices · Cold chain · continued

Domestic fridge temperature mapping: a cheap experiment — what changed since posts 61–90

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

LW
l.wikstromTL23 Mar 2025 · edited#61
r.girard, post #17: The arithmetic in post #16 is right; the assumption feeding it is the part to check. Repacking cold material into a domestic refrigerator promptly on arrival is the one step that is entirely within your control and the one most often delayed. Flagging that the sources on this are thinner than the confidence in the thread suggests. Go to post

Domestic refrigeration: most lyophilised peptides are stored at 2–8 °C (35–46 °F). That is standard refrigerator temperature. Check your refrigerator's actual temperature; some are warmer than the label.

I have kept the units in throughout, for the obvious reason.

23 likes in reply to #17 17mo
VN
v.nascimentoTL25 Mar 2025#62

My position on Domestic fridge temperature mapping is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.

11 likes 17mo
NR
n.rahimiTL27 Mar 2025#63
PA
p.amankwahTL29 Mar 2025#64

Taking post #62 at face value and following it one step further.

Summer routes and winter routes are genuinely different problems, and a supplier that changes its packing between them is doing something rather than nothing.

0 likes 17mo
DO
d.oyelaranTL3Pharmacist11 Mar 2025#65
st.diallo, post #24: Thank you for taking the time. That was more work than a reply usually is. Go to post

Temperature loggers in the parcel exist and are occasionally used for high-value shipments. They are the only thing that turns an argument about transit into a record.

The number is defensible. The precision I gave it is not.

31 likes in reply to #24 17mo
CT
c.tullochTL212 Mar 2025#66
m.guerrero, post #10: This follows post #7 rather than contradicting it. A phase-change pack holds a defined temperature while it changes state and then behaves like anything else. A gel pack starts cold and warms continuously. They are different tools for different transit lengths. Go to post

A phase-change pack holds a defined temperature while it changes state and then behaves like anything else. A gel pack starts cold and warms continuously. They are different tools for different transit lengths.

The strength of my opinion here exceeds the strength of my evidence.

16 likes in reply to #10 17mo
K
KLindqvistTL4 Moderator14 Mar 2025#67

Post #64 put the caveat in the right place and I want to underline it.

If you are new and reading this thread for the answer to Domestic fridge temperature mapping: the answer is conditional, the conditions are in the third reply, and the rest of the thread is worth skipping.

3 likes 16mo
FK
f.kimaniTL216 Mar 2025#68

Where the Domestic fridge temperature mapping discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the same sentence with different clothes on.

0 likes 16mo
SA
s.achebeTL218 Mar 2025#69

A parcel sitting in a vehicle or a depot in a hot month is the excursion that matters and the one nobody sees. Delivery timing is part of the cold chain.

11 likes 16mo
V
VThorvaldsenTL3Regular19 Mar 2025 · edited#70

The arithmetic in post #67 is right; the assumption feeding it is the part to check.

On Domestic fridge temperature mapping I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads get heated.

3 likes 16mo
AK
ak.kravchenkoTL221 Mar 2025#71
e.ndiaye, post #28: The arithmetic in post #27 is right; the assumption feeding it is the part to check. Temperature excursions: brief excursions above 8 °C are tolerable for most compounds. Hours to a day at room temperature is usually acceptable. Days to weeks at room temperature risks degradation. Go to post

Posting my Domestic fridge temperature mapping numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

2 likes in reply to #28 16mo
AD
ambient_draftTL3Regular23 Mar 2025#72

Second this, and I would have said it less carefully.

8 likes 16mo
MA
mi.amankwahTL225 Mar 2025#73
L
LJankowiakTL3Regular26 Mar 2025#74

Answering the question post #71 raises rather than the one it answers.

Domestic refrigeration: most lyophilised peptides are stored at 2–8 °C (35–46 °F). That is standard refrigerator temperature. Check your refrigerator's actual temperature; some are warmer than the label.

0 likes 16mo
AC
a.cardosoTL228 Mar 2025#75

On Domestic fridge temperature mapping the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.

0 likes 16mo
BR
buffer_reviewTL3Regular30 Mar 2025#76

Temperature excursions: brief excursions above 8 °C are tolerable for most compounds. Hours to a day at room temperature is usually acceptable. Days to weeks at room temperature risks degradation.

Not disagreeing with anyone above, just adding the bit I keep having to look up.

4 likes 16mo
AN
a.norgaardTL21 Apr 2025#77

Narrowing post #74, because the general version has more than one answer.

Temperature logging: devices that record temperature over time let you confirm cold chain was maintained. Useful if a shipment was delayed or if you are concerned about excursion.

19 likes 16mo
TI
trough_indexTL3Regular2 Apr 2025 · edited#78
j.silva, post #14: No disagreement from me. Posting only so the question does not look ignored. Go to post

Domestic fridge temperature mapping looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.

0 likes in reply to #14 16mo
NR
n.ramosTL24 Apr 2025 · edited#79
a.mwangi, post #48: Following this. I have the same question and no better information than the first post. Go to post

Agreed on all of that, and I have nothing to add to it.

0 likes in reply to #48 16mo
I
IHollingworthTL26 Apr 2025#80
II
i.ilungaTL28 Apr 2025 · edited#81

I read post #77 twice before replying, because I had assumed the opposite.

Repacking cold material into a domestic refrigerator promptly on arrival is the one step that is entirely within your control and the one most often delayed.

13 likes 16mo
SL
sleep_logTL2Regular9 Apr 2025#82
l.aaltonen, post #19: The thing about Domestic fridge temperature mapping that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result. Go to post

Assessing an excursion: if a package sat at room temperature for a time, visual inspection (cloudiness, discoloration, particles) can alert you to problems. Not visible does not mean not damaged, but visible problems are a reason to contact the supplier.

Adding the caveat now so it does not have to be extracted later.

4 likes in reply to #19 16mo
RW
r.weissTL211 Apr 2025#83

Offering a way to settle Domestic fridge temperature mapping rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference is within the noise, the question was not answerable at this precision.

0 likes 16mo
IA
i.aranda_esTL2Translator · ES13 Apr 2025#84

Second-hand on Domestic fridge temperature mapping, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.

0 likes 15mo
SA
s.adebayoTL214 Apr 2025#85

Grateful for the specificity. Vague answers to this question are what sent me looking.

18 likes 15mo
FN
formulary_notesTL3Regular16 Apr 2025#86
l.chevalier, post #29: Answering the Domestic fridge temperature mapping question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how the first measurement was taken. Go to post

Repacking cold material into a domestic refrigerator promptly on arrival is the one step that is entirely within your control and the one most often delayed.

I am aware this is the third time this month I have made this point.

8 likes in reply to #29 15mo
LV
l.vukovicTL218 Apr 2025#87

Dry ice is rarely used for this material and brings its own transport constraints. Its absence is not a shortcoming.

Reporting the observation and leaving the explanation open deliberately.

1 like 15mo
WP
weekly_pinTL2Regular19 Apr 2025#88

Picking up post #86: that is the part I would want checked first.

The bit of Domestic fridge temperature mapping that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.

0 likes 15mo
DA
d.achebeTL221 Apr 2025#89

The documentation on Domestic fridge temperature mapping is better than this thread and I say that as someone who has posted in the thread.

25 likes 15mo
N
NorringtonTL3Regular23 Apr 2025 · edited#90

The practical question after a warm arrival is what to do, and there is no test at home that answers it. Independent testing is the only route to an actual answer.

I am reporting what happened, not recommending it.

12 likes 15mo