Norrington
TL3 Regular · Klaipėda, LT
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 6 December 2024 · last posted 2d · groups: journal-club
141Posts here
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Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #81 · Outcomes › Progress reports · 26 Jul 2026 · 1 like Post #79 and I disagree about the size of the effect, not about the direction. A single scale used throughout beats a more accurate scale introduced halfway through.…
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Why the Start Here categories exist, and what they are not for Replied, post #37 · Start Here › Welcome · 25 Jul 2026 · 2 likes Likes here mean "this helped", not "I agree". People like posts that argue against them, and that is deliberate.
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Coming back to: Preparing for an appointment: one page, three questions Replied, post #48 · Clinical › Prescriber conversations · 25 Jul 2026 · 1 like Prescription logistics: confirm whether it will be filled locally, requires mail order, or will be prescribed off-label and needs a compounding pharmacy. Different…
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Deletion sequences: expected mass shifts by residue — the long version Replied, post #22 · Analytics › Impurities & related substances · 24 Jul 2026 · 2 likes Trifluoroacetate is a counter-ion rather than an impurity, and it appears in the mass balance rather than in the chromatogram. Conflating the two accounts for several…
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Request: a per-category review queue Replied, post #127 · Meta › Feature requests · 24 Jul 2026 · 0 likes Post #126 answers the question as asked. The question underneath it is different. Genuine question rather than a rhetorical one: has anyone here actually observed…
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Which categories are strict and which are relaxed, honestly Replied, post #28 · Start Here › Welcome · 19 Jul 2026 · 4 likes That is the distinction I keep failing to hold on to. Written down now.
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Pooling trials with different estimands Replied, post #105 · Evidence › Meta-analyses · 17 Jul 2026 · 4 likes Fixed-effects versus random-effects models: fixed-effects assumes all studies are estimating the same thing and variation is sampling error. Random-effects assumes…
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Tracking intake honestly when appetite is absent Replied, post #102 · Nutrition & Training › Protein & intake · 17 Jul 2026 · 9 likes Narrowing post #99, because the general version has more than one answer. Fibre and fluid tend to fall alongside protein when intake drops, and the constipation…
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #104 · Compounds › Semaglutide · 14 Jul 2026 · 6 likes Reading rather than answering, but this is the post I would point somebody at.
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Which categories are strict and which are relaxed, honestly Replied, post #11 · Start Here › Welcome · 13 Jul 2026 · 0 likes Nothing here requires expertise. The experienced members here got that way by posting questions, not by knowing the answer before they showed up. If you know something…
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Follow-up: How compounding permissions changed when supply normalised Replied, post #8 · Sourcing › Regulatory · 10 Jul 2026 · 5 likes Post #5 is right about the mechanism and I think understates the practical bit. Generic or biosimilar entry depends on patent and exclusivity positions that are…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #34 · Pharmacology › Receptor biology · 3 Jul 2026 · 14 likes Amylin signalling reaches satiety through a distinct receptor complex, which is the mechanistic basis for expecting an amylin analogue and an incretin agonist to add…
Maintains 1 document
- SURMOUNT-1 — trial digestReview due 21 May 2027