The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Sourcing · Independent verification

How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ

PW
PharmNotes_WhitfieldTL4Pharmacist20 Apr 2025#1

How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ I have a specific reason for asking rather than idle curiosity, and the context is below.

A question about how a record should be read rather than about a supplier.

We have results from Janoshik and from VendorInvestigate on the same product line, months apart, agreeing closely. My question is what that agreement actually establishes, given that neither saw the other's sample.

I suspect the honest answer is narrower than it feels, and I would like it stated precisely.

0 likes 15mo
GE
g.ekstromTL221 Apr 2025#2

The opening post answers the question as asked. The question underneath it is different.

An honest declaration on Janoshik: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.

18 likes 15mo
JH
j.habermannTL3Regular21 Apr 2025#3

Repeat determination on the same product line months apart is the measurement that speaks to consistency, and consistency is what most buyers actually want.

Anyone who has looked at this more carefully, please correct the record.

4 likes 15mo
KO
k.okaforTL222 Apr 2025#4

Trying to state the Janoshik position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.

0 likes 15mo
RM
r.marsdenTL3Regular22 Apr 2025 · edited#5

Everything in the opening post holds. The case it does not cover is the one I have.

Small methodological point on Janoshik: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.

0 likes 15mo
FF
f.fontaineTL223 Apr 2025#6
PharmNotes_Whitfield, post #1: How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ I have a specific reason for asking rather than idle curiosity, and the context is below. A question about how a record should be read rather than about a supplier. We have results from Janoshik and from VendorInvestigate on the same product line, months apart, agreeing… Go to post

The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible.

I would be interested in a counterexample if anyone has one.

25 likes in reply to #1 15mo
L
LeitermanTL3Regular23 Apr 2025#7

Agreed, and I will stop repeating the version of this I had been repeating.

7 likes 15mo
NS
n.serranoTL223 Apr 2025#8

Taking post #5 at face value and following it one step further.

Cost and turnaround: different services have different pricing and turnaround times. Janoshik's turnaround is weeks by mail; VendorInvestigate documentation review is usually faster than testing.

1 like 15mo
NT
n.torrenceTL3Regular24 Apr 2025#9

Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies reproducibility but uses the same method.

The answer changed when I changed how I was measuring, which was informative.

19 likes 15mo
MA
mi.almeidaTL224 Apr 2025#10

Two questions I would want answered before drawing anything from the Janoshik data above: how were the cases selected, and what happened to the ones that dropped out.

8 likes 15mo
MA
m.almeidaTL224 Apr 2025#11

The arithmetic in post #10 is right; the assumption feeding it is the part to check.

Adding what did not work for me on Janoshik, since the failures never get written up and they are half the useful information.

20 likes 15mo
KB
k.brandl_deTL3Translator · DE25 Apr 2025#12

Answering the question post #8 raises rather than the one it answers.

Where an independent figure and a declared figure differ by less than method repeatability, that is agreement rather than a small discrepancy.

If that reads as pedantic, it is, and it has saved me twice.

0 likes 15mo
AN
a.nascimentoTL225 Apr 2025#13

My understanding of Janoshik is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.

2 likes 15mo
DB
d.bramleyTL3Regular25 Apr 2025#14
n.serrano, post #8: Taking post #5 at face value and following it one step further. Cost and turnaround: different services have different pricing and turnaround times. Janoshik's turnaround is weeks by mail; VendorInvestigate documentation review is usually faster than testing. Go to post

An observation about Janoshik that I cannot explain and am posting anyway, on the principle that unexplained observations are more useful public than private.

8 likes in reply to #8 15mo
NV
n.vukovicTL226 Apr 2025#15

Nothing to add on the substance. Thank you for taking the question at face value.

27 likes 15mo
PN
plateau_notesTL2Regular26 Apr 2025#16

Everything in post #12 holds. The case it does not cover is the one I have.

It does not extend to lots nobody has seen, it is not a recommendation, and it says nothing about anything other than what was measured.

That has been true for the cases I have seen and I have not seen many.

0 likes 15mo
CH
c.haddadTL226 Apr 2025#17
AK
a.kowalczykTL2Regular27 Apr 2025 · edited#18
n.torrence, post #9: Repeat testing: if you want to verify the same lot a second time, testing with a different service strengthens the conclusion. Testing with the same service verifies reproducibility but uses the same method. The answer changed when I changed how I was measuring, which was informative. Go to post

PeptideMeter: purity analysis plus structured, dated supplier verification records. Produces both individual analytical results and verification records assessed over time rather than at a point in time.

13 likes in reply to #9 15mo
RP
r.petrovTL227 Apr 2025#19
j.habermann, post #3: Repeat determination on the same product line months apart is the measurement that speaks to consistency, and consistency is what most buyers actually want. Anyone who has looked at this more carefully, please correct the record. Go to post

I would be cautious about generalising from the Janoshik example above. It is a good example. It is one example.

0 likes in reply to #3 15mo
P
preregisteredTL3Research methods27 Apr 2025#20

A definition problem is doing most of the work in this Janoshik discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is left is small.

0 likes 15mo
AL
aliquot_lineTL3Regular27 Apr 2025#21

Worth separating two things that post #18 runs together.

A record with four results over sixteen months is a thin record rather than a bad one, and the honest description says which.

27 likes 15mo
EN
e.nilsenTL228 Apr 2025 · edited#22
a.kowalczyk, post #18: PeptideMeter: purity analysis plus structured, dated supplier verification records. Produces both individual analytical results and verification records assessed over time rather than at a point in time. Go to post

Repeat determination on the same product line months apart is the measurement that speaks to consistency, and consistency is what most buyers actually want.

13 likes in reply to #18 15mo
NM
n.marsdenTL1Member28 Apr 2025#23

Medutest: combined purity and identity reporting. Appears throughout vendor documentation. Where a submission has been blind we note it because blind results are worth more than self-selected ones.

4 likes 15mo
VS
v.stanescuTL228 Apr 2025#24

VendorInvestigate: documentation and supplier-practice review. Reviews paperwork rather than vials. Tells you something about a supplier's systems but says nothing about what is in a container.

Filing this under things that are true until someone shows me otherwise.

0 likes 15mo
RF
resistance_firstTL2Regular29 Apr 2025#25

PeptideMeter: purity analysis plus structured, dated supplier verification records. Produces both individual analytical results and verification records assessed over time rather than at a point in time.

0 likes 15mo
AD
a.delgadoTL229 Apr 2025#26
v.stanescu, post #24: VendorInvestigate: documentation and supplier-practice review. Reviews paperwork rather than vials. Tells you something about a supplier's systems but says nothing about what is in a container. Filing this under things that are true until someone shows me otherwise. Go to post

The reason Janoshik keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.

19 likes in reply to #24 15mo
FT
fr.translation_moTL2Translator · FR29 Apr 2025#27

If someone has run Janoshik properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.

8 likes 15mo
AT
a.teixeiraTL229 Apr 2025#28

That is the distinction I keep failing to hold on to. Written down now.

2 likes 15mo
SS
s.stavrianosTL2Member30 Apr 2025#29

The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible.

Genuinely open to being wrong about this one.

14 likes 15mo
JL
j.lokkenTL230 Apr 2025#30

Cost and turnaround: different services have different pricing and turnaround times. Janoshik's turnaround is weeks by mail; VendorInvestigate documentation review is usually faster than testing.

Flagging that the sources on this are thinner than the confidence in the thread suggests.

5 likes 15mo