Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset

Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that.

Posting a small dataset on SURMOUNT-4 and continuation versus withdrawal. It is mine, it is uncontrolled, and the method is stated so it can be discounted appropriately.

What I would like is not agreement but a second dataset collected by someone with no stake in mine. If one exists I would rather read it than argue for this one.

Sessions on negative or null results are consistently the most instructive and the hardest to get anyone to attend.

The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.

I would not lead a decision with this, but I would not ignore it either.

On SURMOUNT-4 and continuation versus withdrawal: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply here including this one.

Sessions on negative or null results are consistently the most instructive and the hardest to get anyone to attend.

Reading it again, the caveat matters more than the finding.

An hour is enough for one paper read properly and not enough for two read partly. The temptation is always to add the second.

Somebody will have a better source than mine, and I hope they post it.

Confirming post #39 from a second method, which matters more than confirming it from a second person.

Posting my SURMOUNT-4 and continuation versus withdrawal numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions.

What I can speak to on SURMOUNT-4 and continuation versus withdrawal is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.