The Peptide CommonsEst. May 2024
Independent. We sell nothing and are affiliated with no manufacturer or pharmacy. Every moderation action is logged in public
Practice · Storage & stability · continued

Power cut for eleven hours: how I assessed it afterwards posts 91–110

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

RM
r.mensaTL211 Oct 2025#91
da.bakker, post #78: Power cut for eleven hours sits at the boundary between what this community can usefully discuss and what it cannot, and I think it falls on the discussable side, narrowly. Go to post

Coming back to post #89, because the follow-up matters more than the original answer.

Power cut for eleven hours has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.

1 like in reply to #78 10mo
NG
np_gilmoreTL3Nurse practitioner12 Oct 2025#92

Temperature excursions: if a vial sat at room temperature for a time, the question is whether the excursion was long enough to cause damage. Hours at room temperature is usually low risk. Days to weeks raises the risk. If you are unsure, contacting the supplier is more informative than guessing.

0 likes 10mo
NS
no.silvaTL212 Oct 2025#93

Adding what did not work for me on power cut for eleven hours, since the failures never get written up and they are half the useful information.

23 likes 10mo
PP
peak_purityTL3Analytical chemist13 Oct 2025#94
c.vermeulen, post #18: Checked the power cut for eleven hours claim against the primary source this morning. It survives, with a narrower scope than the version quoted here. Posting the narrower scope. Go to post

This follows post #93 rather than contradicting it.

My understanding of power cut for eleven hours is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.

10 likes in reply to #18 9mo
RZ
r.zielinskiTL214 Oct 2025#95

Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.

3 likes 9mo
RA
r.aldana_pharmdTL4Pharmacist14 Oct 2025#96

The bit of power cut for eleven hours that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.

0 likes 9mo
CB
c.boatengTL215 Oct 2025#97

On post #93 — agreed on the reasoning, with one qualification.

An observation about power cut for eleven hours that I cannot explain and am posting anyway, on the principle that unexplained observations are more useful public than private.

30 likes 9mo
MP
mira.patelTL4 Admin16 Oct 2025#98
d.yilmaz, post #29: Post #27 answers the question as asked. The question underneath it is different. I think the power cut for eleven hours question is answerable and has not been answered, which is a more optimistic position than most of this thread. Go to post

Picking up post #97: that is the part I would want checked first.

Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.

15 likes in reply to #29 9mo
EN
e.ndiayeTL217 Oct 2025#99

Where the power cut for eleven hours discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the same sentence with different clothes on.

6 likes 9mo
DS
d.szymanskiTL3Wiki editor17 Oct 2025#100

Post #97 is the version of this I will quote in future. One addition.

The arithmetic on power cut for eleven hours is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.

1 like 9mo
FF
f.fonsecaTL218 Oct 2025#101

Post #97 describes the usual case. This is about the unusual one.

Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.

One of those cases where knowing the mechanism does not help the decision.

2 likes 9mo
FW
f.wojcikTL219 Oct 2025#102

Sensible. I would want the same detail before I acted on it either.

0 likes 9mo
AA
a.aguirreTL220 Oct 2025 · edited#103

Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.

I have deliberately not rounded that, because the rounding is where the argument starts.

27 likes 9mo
BO
b.okonkwoTL220 Oct 2025#104
a.frisk, post #35: Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed. I am not the right person to answer the follow-up to this. Go to post

Distinguishing three things in the power cut for eleven hours discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the recommendation that gets attached to both.

13 likes in reply to #35 9mo
EO
e.okaforTL221 Oct 2025#105

The strongest argument against my own position on power cut for eleven hours, stated as well as I can state it, since nobody else has yet.

4 likes 9mo
AS
a.sorensenTL222 Oct 2025#106

The arithmetic in post #105 is right; the assumption feeding it is the part to check.

Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.

Written quickly, so the reasoning may be tighter than the wording.

0 likes 9mo
SR
s.rasmussenTL222 Oct 2025#107

Trying to state the power cut for eleven hours position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.

0 likes 9mo
LT
l.trevinoTL223 Oct 2025#108
l.aaltonen, post #47: Something worth flagging about power cut for eleven hours: the strongest-sounding claims in this thread are the ones with no source attached, which is the usual pattern and not a coincidence. Go to post

Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.

Two people can read the same figure differently here and both be reasonable.

19 likes in reply to #47 9mo
J
JFitzgibbonTL2Member24 Oct 2025#109
baseline_table, post #24: Where I part company with post #20, and it is a narrow parting. Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed. Speaking for myself and not for anyone else who has posted here. Go to post

An honest declaration on power cut for eleven hours: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.

0 likes in reply to #24 9mo
ND
n.dziedzicTL225 Oct 2025#110

Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.

The uncertainty is in the assumption, not in the calculation.

28 likes 9mo

Suggested topics

TopicParticipantsRepliesViewsActivity
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile
On the subject in the title: Second pass at: Adsorptive losses at low concentration, and why dilute solutions are fragile Working notes rather than a conclusion. The question about Adsorptive losses that I…
SRMNWFYVS+77 87 58k 4mo
A parcel that arrived warm: a decision process, not a verdict
A parcel that arrived warm: a decision process, not a verdict Writing it up because I had to work it out twice and would rather nobody else did. Asking about the failure mode rather than the procedure,…
VFHLWPSAEF+130 140 12k 8mo
Refrigerated versus room temperature: the trade-off stated plainly — what changed since
Posting this under the heading it deserves: Refrigerated versus room temperature: the trade-off stated plainly — what changed since Everything below is what sits behind that. What changes if the standard…
SOKPBN 2 2.7k 9mo
Transporting a vial for a weekend away — a second dataset
Transporting a vial for a weekend away — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Transporting a vial. It is mine, it is…
JMCNTSAWAD+74 84 5.1k 1mo
About the Storage & stability category
Refrigeration, excursions, light exposure, freeze-thaw, beyond-use dating, and what published stability data actually covers. This post is a community wiki: any member at trust level 3 or above can edit it,…
TVHSJVSTVS 4 57k 4mo

Related topics — sharing the tags beyond-use date, freeze-thaw, storage

TopicParticipantsRepliesViewsActivity
Second pass at: Domestic fridge temperature mapping: a cheap experiment
Posting this under the heading it deserves: Second pass at: Domestic fridge temperature mapping: a cheap experiment Everything below is what sits behind that. Two things I would like separated before anyone…
DBEMET 2 30k 16mo
Travel coolers and how long they really hold
On the subject in the title: Travel coolers and how long they really hold Working notes rather than a conclusion. A narrow question about travel coolers, deliberately narrow, because the broad version has…
NBADADSATH+78 84 14k 12mo
Preservatives: function, testing, and limits — one year on
On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…
SDKBBHKHA+28 32 437 8d
A reconstituted vial's beyond-use date and the reasoning behind common figures
Posting this under the heading it deserves: A reconstituted vial's beyond-use date and the reasoning behind common figures Everything below is what sits behind that. I have read the maintained page on this…
DOTHAMEHR+125 129 45k 2mo
Cold packs, phase-change material, and what survives ten days — does this still hold?
Asking directly, because I could not find a straight answer: Cold packs, phase-change material, and what survives ten days — does this still hold? I have spent a fortnight trying to pin Cold packs down and I…
PRKMO 2 22k 22mo