GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth hormone. Ghrelin mimetics (like GHRPs) act on the ghrelin receptor directly. The effect on growth hormone secretion is similar but the mechanisms are…
What a well-designed human trial of a secretagogue would look like I have a specific reason for asking rather than idle curiosity, and the context is below.
I was wrong about well-designed human trial in a thread last spring and I would like to correct it publicly rather than quietly.
The error was in the units, which changed the conclusion by an order of magnitude. Setting out the corrected version, and the way I now check for that class of mistake.
The opening post is right about the mechanism and I think understates the practical bit.
Tesamorelin has an approved indication in HIV-associated lipodystrophy. That is the only compound in this class with a registration-quality evidence base from a proper trial programme. Generalising from that narrow population to healthy adults is a substantial extrapolation.
GHRH analogues versus ghrelin mimetics are often conflated but they are different mechanisms. GHRH analogues (like CJC-1295) cause the pituitary to release growth hormone. Ghrelin mimetics (like GHRPs) act on the ghrelin receptor directly. The effect on growth hormone secretion is similar but the mechanisms are distinct.
A single observation, in a thread that deserves better than single observations.
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Reading a rodent study on a secretagogue without over-extrapolating — the long version
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+59 | 66 | 30k | 4h |
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Secretagogues and glucose tolerance: the mechanistic concern — what changed since
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Follow-up: Evidence quality in the secretagogue literature: an honest assessment
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+20 | 24 | 18k | 4mo |
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Secretagogues and glucose tolerance: the mechanistic concern
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+64 | 70 | 52k | 17d |
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GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion
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+47 | 53 | 6.9k | 2h |
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Coming back to: Measurement error in a self-reported exposure
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+23 | 27 | 49k | 3mo |
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Ipamorelin selectivity claims and where they came from — a second dataset
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2 | 27k | 14mo | |
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2 | 2k | 18mo | |
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Follow-up: Evidence quality in the secretagogue literature: an honest assessment
On the subject in the title: Evidence quality in the secretagogue literature: an honest assessment Working notes rather than a conclusion. A follow-up question about Evidence quality that I did not know to…
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+20 | 24 | 18k | 4mo |
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A structured critique template this community uses
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