Ranked by engagement

Top topics — all time page 37

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 37 of 40

Topic	Participants	Replies	Views	Activity
TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? Compounds › Repair & healing peptides TB-500 BPC-157 needs a source Closed TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Two things I would like separated…	+19	23	4.2k	19mo
Why I now write the concentration on the vial in marker Practice › Reconstitution syringe units bacteriostatic water concentration maths Asking directly, because I could not find a straight answer: Why I now write the concentration on the vial in marker Writing this out with the numbers in it, because "roughly" is how these go wrong. Vial: 15…	+1	5	30k	11d
Titrating on tolerability rather than on the calendar Practice › Dosing & titration dose reduction tirzepatide worked example missed dose On the subject in the title: Titrating on tolerability rather than on the calendar Working notes rather than a conclusion. An honest uncertainty about titrating on tolerability rather than a disguised…		2	31k	13mo
Specification in the result column: why that is a meaningful error — the long version Analytics › COA interpretation batch & lot numbers documentation quality certificate of analysis reference standards Specification in the result column: why that is a meaningful error — the long version Writing it up because I had to work it out twice and would rather nobody else did. A documentation question rather than an…	+14	18	12k	17mo
Appeal templates and why they are deliberately unemotional Access › Insurance & coverage formulary insurance prior authorisation appeals Posting this under the heading it deserves: Appeal templates and why they are deliberately unemotional Everything below is what sits behind that. A narrow question about appeal templates, deliberately narrow,…	+25	29	764	7mo
[2026 update] Documenting an adverse event properly Safety › Adverse events pancreatitis vomiting gallbladder Documenting an adverse event properly Writing it up because I had to work it out twice and would rather nobody else did. Asking about Documenting an adverse event on behalf of the question I keep seeing asked…	+18	22	4.3k	1d
Early satiety becoming a problem rather than a benefit Practice › Side effects vomiting fatigue hair shedding constipation Closed Early satiety becoming a problem rather than a benefit — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about early satiety. Everyone…	+20	24	2.5k	6mo
[2026 update] Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses publication bias heterogeneity meta-analysis Heterogeneity as information rather than as a nuisance Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a claim I…		4	32k	11mo
Substitution between formats during a shortage — what changed since Access › Shortages shortage formulary FDA compounding Solved Substitution between formats during a shortage — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Substitution between formats…	+17	21	2.7k	9d
Talking to a therapist about this specifically Wellbeing › Mental health disordered eating beginner friendly mood Solved Posting this under the heading it deserves: Talking to a therapist about this specifically Everything below is what sits behind that. Something that has come up for me and that I suspect is more common than…	+20	24	855	14h
About the Pharmacokinetics category Pharmacology › Pharmacokinetics semaglutide tirzepatide liraglutide Pinned Wiki Half-life, accumulation, steady state, albumin binding, and why weekly dosing works. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author…		4	32k	8mo
Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Evidence › Journal club risk of bias journal club effect size estimand Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Posting a small dataset on STEP 8. It is…	+18	22	656	13h
Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? Evidence › Journal club estimand randomised trial number needed to treat effect size Solved Closed Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A narrow question about semaglutide…		3	28k	6mo
Coming back to: What consumer-accessible tests can and cannot determine Analytics › Home & field testing third-party testing documentation quality LOD & LOQ ELISA Asking directly, because I could not find a straight answer: What consumer-accessible tests can and cannot determine Something about consumer-accessible tests does not reconcile and I would like a second pair…	+4	8	25k	22mo
NHS criteria and how they are applied in practice — the long version Regional › UK & Ireland cost per milligram NHS MHRA Posting this under the heading it deserves: NHS criteria and how they are applied in practice — the long version Everything below is what sits behind that. A narrow question about NHS criteria, deliberately…	+11	15	11k	9mo
GIP receptor agonism and the argument about direction — does this still hold? Pharmacology › Receptor biology long read amylin analogues retatrutide Solved GIP receptor agonism and the argument about direction — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. A question about GIP receptor agonism…	+10	14	15k	16h
Absolute versus relative contraindications Safety › Contraindications pregnancy & planning delayed gastric emptying pancreatitis On the subject in the title: Absolute versus relative contraindications Working notes rather than a conclusion. Proposing that absolute versus relative contraindications deserves a maintained page rather than…	+4	8	23k	8mo
Type 2 diabetes and the largest part of the evidence base — does this still hold? Clinical › Comorbidities type 2 diabetes chronic kidney disease PCOS blood pressure Solved Type 2 diabetes and the largest part of the evidence base — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Trying to work out what would count…	+17	22	4.5k	1d
Rewriting my first post: a before-and-after, with commentary — what changed since Start Here › How to Ask site feedback onboarding beginner friendly worked example Posting this under the heading it deserves: Rewriting my first post: a before-and-after, with commentary — what changed since Everything below is what sits behind that. I want to check my reasoning rather…	+15	19	12k	13h
Where to report an adverse event officially, by region Safety › Adverse events pancreatitis gallbladder vomiting hypoglycaemia Solved Where to report an adverse event officially, by region Writing it up because I had to work it out twice and would rather nobody else did. Reporting an event with the dates and the sequence, because…		2	27k	1h
Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC system suitability peak integration gradient method data table Solved Why 99.2% and 97.8% on the same lot can both be correct I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+16	20	3.1k	11h
Batch date after test date, and other internal inconsistencies Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers documentation quality Batch date after test date, and other internal inconsistencies — setting out what I have, and where I think it stops being reliable. Proposing that batch date deserves a maintained page rather than a…	+27	31	4.9k	7mo
[2026 update] Distinguishing expected GI effects from something that needs urgent attention Practice › Side effects vomiting fatigue constipation delayed gastric emptying On the subject in the title: Distinguishing expected GI effects from something that needs urgent attention Working notes rather than a conclusion. Reporting something rather than asking about it, in case the…	+10	14	11k	4mo
Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Compounds › Retatrutide retatrutide randomised trial effect size preprint Solved Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Writing it up because I had to work it out twice and would rather nobody else did. A methods question rather than a substantive…	+10	14	8.4k	16h
Comparators chosen for regulatory reasons rather than clinical ones Evidence › Trials surrogate endpoints open label estimand randomised trial Pinned Closed On the subject in the title: Comparators chosen for regulatory reasons rather than clinical ones Working notes rather than a conclusion. An honest uncertainty about comparators chosen for regulatory reasons…		2	27k	14mo
Second pass at: Domestic fridge temperature mapping: a cheap experiment Devices › Cold chain temperature excursion cold chain freeze-thaw storage Solved Posting this under the heading it deserves: Second pass at: Domestic fridge temperature mapping: a cheap experiment Everything below is what sits behind that. Two things I would like separated before anyone…		2	30k	16mo
[2026 update] Building a sensible monitoring schedule with your prescriber Clinical › Bloodwork thyroid function HbA1c lipid panel lipase & amylase Closed Posting this under the heading it deserves: Building a sensible monitoring schedule with your prescriber Everything below is what sits behind that. Reading back through what has been written here about…	+22	26	5.1k	14mo
Revisiting: What to include when your question involves arithmetic Start Here › How to Ask worked example site feedback onboarding beginner friendly Revisiting: What to include when your question involves arithmetic — setting out what I have, and where I think it stops being reliable. Counting it rather than describing it, because the count is the part…	+21	25	384	12mo
Second pass at: I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome onboarding trust levels beginner friendly Solved Second pass at: I joined for one answer and stayed for a year — what changed my mind — setting out what I have, and where I think it stops being reliable. Question in the title and the context underneath, in…		4	25k	2mo
Cleaning a self-reported dataset and what you throw away Data & Tools › Datasets confounding site feedback data table observational data Cleaning a self-reported dataset and what you throw away — setting out what I have, and where I think it stops being reliable. Collecting what is known about cleaning a self-reported dataset in one place,…		2	28k	1d