Ranked by engagement

Top topics — this quarter page 6

Ranked by replies, likes and views over this quarter, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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515 topics · page 6 of 14

Topic	Participants	Replies	Views	Activity
Programming during a large energy deficit Nutrition & Training › Resistance training lean mass loss fatigue DXA Programming during a large energy deficit — setting out what I have, and where I think it stops being reliable. Programming during a large energy: what I expected, what I found, and the gap between them. I am…	+39	49	36k	2d
Injection volume, overload, and peak distortion Analytics › HPLC & UHPLC peak integration system suitability HPLC data table Solved Posting this under the heading it deserves: Injection volume, overload, and peak distortion Everything below is what sits behind that. I have spent a fortnight trying to pin injection volume down and I want…	+43	47	36k	2mo
What "marked as solution" means and who gets to mark it — does this still hold? Start Here › Welcome onboarding beginner friendly guidelines Solved What "marked as solution" means and who gets to mark it — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather…	+69	74	2.4k	3mo
Why fasting instructions for oral semaglutide are not optional advice Compounds › Oral incretins PIONEER programme orforglipron randomised trial SOUL trial Solved Why fasting instructions for oral semaglutide are not optional advice I have a specific reason for asking rather than idle curiosity, and the context is below. Fasting instructions for oral semaglutide, from…	+70	74	1.1k	23d
A checklist for reading a certificate in under two minutes Analytics › COA interpretation certificate of analysis batch & lot numbers amino acid analysis Solved A checklist for reading a certificate in under two minutes — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it anywhere.…	+39	46	38k	1mo
Amylin receptor signalling and satiety — what changed since Pharmacology › Receptor biology tirzepatide retatrutide long read amylin analogues On the subject in the title: Amylin receptor signalling and satiety — what changed since Working notes rather than a conclusion. What changes if the standard account of Amylin receptor signalling and satiety…	+73	78	3.5k	2mo
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…	+70	76	4.8k	15h
Bioimpedance and hydration: why the number moves Outcomes › Body composition lean mass loss data table DXA bioimpedance Bioimpedance and hydration: why the number moves — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin bioimpedance and hydration down and I want to set…	+62	70	13k	23d
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+63	74	11k	1d
A 10 mg vial reconstituted three different ways, compared Practice › Reconstitution bacteriostatic water worked example concentration maths Posting this under the heading it deserves: A 10 mg vial reconstituted three different ways, compared Everything below is what sits behind that. Something about 10 mg vial reconstituted three does not…	+30	34	55k	17h
Peak-to-trough ratio at steady state for a weekly agent Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose Solved On the subject in the title: Peak-to-trough ratio at steady state for a weekly agent Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the…	+58	64	9.7k	2mo
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on PCOS and metabolic…	+55	59	26k	2d
Follow-up: How compounding permissions changed when supply normalised Sourcing › Regulatory MHRA personal import research use only How compounding permissions changed when supply normalised I have a specific reason for asking rather than idle curiosity, and the context is below. I was wrong about compounding permissions in a thread last…	+72	77	1.5k	1d
Coming back to: A structured critique template this community uses Evidence › Study critique confounding risk of bias disputed observational data Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Reading back through what has been written here about structured…	+63	69	17k	18h
The best-written scientific paper you have read Lounge › Off topic long read beginner friendly The best-written scientific paper you have read Writing it up because I had to work it out twice and would rather nobody else did. Asking about best-written scientific paper directly, because I have read four…	+69	74	1.1k	2mo
What to include when your question involves a chromatogram — one year on Start Here › How to Ask worked example guidelines site feedback onboarding Asking directly, because I could not find a straight answer: What to include when your question involves a chromatogram — one year on Question in the title. Context below, and I have tried to include the…	+69	75	862	14d
Revisiting: Mean kinetic temperature explained without the mathematics Practice › Storage & stability storage cold chain temperature excursion cloudy or discoloured solution Solved Revisiting: Mean kinetic temperature explained without the mathematics Writing it up because I had to work it out twice and would rather nobody else did. A methods question rather than a substantive one,…	+67	75	909	2mo
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC HPLC system suitability gradient method Detection wavelength and why 214 nm and 280 nm disagree — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on Detection wavelength,…	+69	76	920	6h
The headache that turns out to be dehydration — the long version Nutrition & Training › Hydration & electrolytes blood pressure fatigue heart rate Under review On the subject in the title: The headache that turns out to be dehydration — the long version Working notes rather than a conclusion. A narrow question about headache, deliberately narrow, because the broad…	+68	73	1.3k	12h
Does dual agonism explain the effect size, or is it dose? Compounds › Tirzepatide SURPASS programme SURMOUNT programme tirzepatide randomised trial Solved Does dual agonism explain the effect size, or is it dose? I have a specific reason for asking rather than idle curiosity, and the context is below. A question about dual agonism that I think has a definite…	+62	68	2.6k	29d
Pancreatitis history and the risk calculus Safety › Contraindications delayed gastric emptying thyroid C-cell question pancreatitis pregnancy & planning Solved Posting this under the heading it deserves: Pancreatitis history and the risk calculus Everything below is what sits behind that. I would like to know what people here actually do about pancreatitis history,…	+28	32	52k	17h
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Pharmacology › Receptor biology tirzepatide retatrutide amylin analogues long read Under review Receptor desensitisation as a tolerance hypothesis, and its weak evidence — setting out what I have, and where I think it stops being reliable. Trying to work out what would count as evidence on receptor…	+52	57	25k	just now
Angle of injection and whether 90 degrees is always right — the long version Practice › Administration injection site reaction needle gauge & length injection site rotation missed dose Pinned Angle of injection and whether 90 degrees is always right — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Angle of injection,…	+50	55	15k	2d
Blinding yourself: practical methods and their limits Research Methods › N-of-1 designs confounding data table effect size On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. A methods question rather than a substantive one, about blinding yourself. Everyone…	+40	44	33k	5d
Manufacturer assistance programmes and their eligibility rules Access › Pricing formulary data table compounding On the subject in the title: Manufacturer assistance programmes and their eligibility rules Working notes rather than a conclusion. I have spent a fortnight trying to pin manufacturer assistance programmes…	+37	42	32k	11d
How shortages have affected compounding permissions Access › Shortages shortage compounding FDA formulary How shortages have affected compounding permissions I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what people here actually do about shortages,…	+61	71	3.6k	2d
Aggregate verification data across the directory, with caveats Sourcing › Independent verification Medutest blind sampling PeptideMeter Under review On the subject in the title: Aggregate verification data across the directory, with caveats Working notes rather than a conclusion. I have spent a fortnight trying to pin aggregate verification data down and…	+64	74	4.6k	14h
Follow-up: Reading an interaction checker output critically Practice › Interactions insulin hypoglycaemia delayed gastric emptying needs a source Solved Reading an interaction checker output critically — setting out what I have, and where I think it stops being reliable. A follow-up question about Reading an interaction checker output that I did not know to…	+62	66	13k	2d
Reused chromatograms across lots: how to spot it Analytics › COA interpretation batch & lot numbers amino acid analysis documentation quality certificate of analysis On the subject in the title: Reused chromatograms across lots: how to spot it Working notes rather than a conclusion. Something about reused chromatograms across lots does not reconcile and I would like a…	+53	60	9.5k	4h
Why the Start Here categories exist, and what they are not for Start Here › Welcome guidelines trust levels onboarding beginner friendly Solved Why the Start Here categories exist, and what they are not for — that is the question, and I have not found it answered plainly anywhere I have looked. Collecting what is known about Start in one place,…	+40	44	32k	1d