20 categories

Practice

The practical mechanics: arithmetic, preparation, handling, administration, and managing what goes wrong.

194 topics10,175 posts48 solved Moderators: bench_notes, KLindqvist About this category

Dosing & titration 35 Reconstitution 33 Administration 33 Storage & stability 30 Side effects 33 Interactions 30

194 topics · page 6 of 7

Topic	Participants	Replies	Views	Activity
Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration subcutaneous injection aseptic technique needle gauge & length injection site reaction Closed Revisiting: Completing a dose with a second syringe, and the dead-volume arithmetic Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this…	+16	20	56k	12mo
Antibiotics and a course of something with delayed emptying Practice › Interactions insulin hypoglycaemia needs a source metformin Antibiotics and a course of something with delayed emptying — setting out what I have, and where I think it stops being reliable. Something about antibiotics does not reconcile and I would like a second pair…	+99	108	1.4k	12mo
Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration dose reduction missed dose semaglutide Holding a dose indefinitely: is there a documented downside? — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have a…	+28	32	57k	12mo
Revisiting: Early satiety becoming a problem rather than a benefit Practice › Side effects hair shedding fatigue delayed gastric emptying nausea Closed On the subject in the title: Revisiting: Early satiety becoming a problem rather than a benefit Working notes rather than a conclusion. Early satiety: setting out the arithmetic in full, because I have had to…		2	14k	12mo
[2026 update] Constipation management, with a dietitian's contribution Practice › Side effects nausea vomiting delayed gastric emptying hair shedding Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. Constipation management: what I expected, what I found, and the gap between them.…	+6	10	812	12mo
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Practice › Reconstitution concentration maths bacteriostatic water syringe units On the subject in the title: A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Working notes rather than a conclusion. A narrow question about 5 mg vial, deliberately narrow, because…	+160	165	1.9k	12mo
A side-effect grading scheme this community uses, and its limits Practice › Side effects constipation hair shedding fatigue Posting this under the heading it deserves: A side-effect grading scheme this community uses, and its limits Everything below is what sits behind that. Side-effect grading scheme keeps being re-asked here and…	+1	5	3.8k	12mo
Titrating on tolerability rather than on the calendar Practice › Dosing & titration dose reduction tirzepatide worked example missed dose On the subject in the title: Titrating on tolerability rather than on the calendar Working notes rather than a conclusion. An honest uncertainty about titrating on tolerability rather than a disguised…		2	31k	13mo
Insulin combinations and hypoglycaemia risk Practice › Interactions metformin needs a source hypoglycaemia insulin Closed On the subject in the title: Insulin combinations and hypoglycaemia risk Working notes rather than a conclusion. I was wrong about insulin combinations and hypoglycaemia risk in a thread last spring and I…	+18	22	7.8k	13mo
[2026 update] Dose numbers across compounds are not on the same scale Practice › Dosing & titration dose reduction worked example semaglutide titration On the subject in the title: Dose numbers across compounds are not on the same scale Working notes rather than a conclusion. A narrow question about Dose numbers across compounds, deliberately narrow, because…	+14	18	1.2k	13mo
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — what changed since Practice › Reconstitution dead volume bacteriostatic water reconstitution syringe units Closed Posting this under the heading it deserves: A 5 mg vial and a 0.25 mg dose: the arithmetic in full — what changed since Everything below is what sits behind that. 5 mg vial: setting out the arithmetic in…	+86	93	25k	13mo
Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions metformin needs a source hypoglycaemia Solved Wiki On the subject in the title: Delayed gastric emptying and oral medication absorption: which drugs matter Working notes rather than a conclusion. A follow-up question about delayed gastric emptying and oral…	+110	116	43k	14mo
A vial that will not fully dissolve: what to check and in what order Practice › Reconstitution reconstitution bacteriostatic water syringe units Solved A vial that will not fully dissolve: what to check and in what order — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+12	16	40k	15mo
Bleeding at the injection site: normal, and what to do about it — does this still hold? Practice › Administration injection site rotation aseptic technique subcutaneous injection needle gauge & length Bleeding at the injection site: normal, and what to do about it — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Something changed and I would…	+20	24	16k	15mo
Metformin co-administration and additive GI effects Practice › Interactions insulin hypoglycaemia metformin delayed gastric emptying Metformin co-administration and additive GI effects Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on metformin…	+28	32	2.1k	15mo
Reaching a dose and staying there for a year: a longitudinal note Practice › Dosing & titration worked example tirzepatide titration semaglutide Reaching a dose and staying there for a year: a longitudinal note Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I still have a…		2	763	15mo
Over-dilution: when your dose falls below one readable graduation Practice › Reconstitution concentration maths syringe units bacteriostatic water dead volume On the subject in the title: Over-dilution: when your dose falls below one readable graduation Working notes rather than a conclusion. I have read the maintained page on this and I still have a gap, so I am…	+15	19	248	15mo
Anaesthesia and elective surgery: the aspiration question — does this still hold? Practice › Interactions needs a source hypoglycaemia metformin Solved Anaesthesia and elective surgery: the aspiration question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about Anaesthesia and…	+23	27	5.6k	17mo
Why side effects reset at each escalation and that is not a failure — the long version Practice › Side effects nausea vomiting fatigue delayed gastric emptying The question in the title: Why side effects reset at each escalation and that is not a failure — the long version I will give what I have already checked below so nobody repeats it. A narrow question about…		2	46k	17mo
Titrating on tolerability rather than on the calendar — the long version Practice › Dosing & titration worked example missed dose titration tirzepatide Titrating on tolerability rather than on the calendar — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Titrating on tolerability,…		2	7.7k	17mo
Coming back to: The nausea timeline across the first four weeks, with a tabulated log Practice › Side effects constipation fatigue nausea delayed gastric emptying Wiki Posting this under the heading it deserves: The nausea timeline across the first four weeks, with a tabulated log Everything below is what sits behind that. Reading back through what has been written here…	+42	49	576	17mo
Levothyroxine timing: a real interaction with a simple fix Practice › Interactions needs a source metformin hypoglycaemia delayed gastric emptying Levothyroxine timing: a real interaction with a simple fix Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about levothyroxine timing, deliberately narrow,…	+20	24	60k	18mo
Revisiting: Holding a dose indefinitely: is there a documented downside? Practice › Dosing & titration titration tirzepatide worked example missed dose Solved The question in the title: Revisiting: Holding a dose indefinitely: is there a documented downside? I will give what I have already checked below so nobody repeats it. I have read the maintained page on this…	+26	30	4.5k	18mo
Escalating every six weeks instead of four: what I observed over eight months Practice › Dosing & titration titration worked example dose reduction Escalating every six weeks instead of four: what I observed over eight months Writing it up because I had to work it out twice and would rather nobody else did. Asking about escalating every six weeks instead…	+27	31	432	18mo
Coming back to: Grapefruit: why this class is not the class that cares Practice › Interactions metformin needs a source insulin Posting this under the heading it deserves: Grapefruit: why this class is not the class that cares Everything below is what sits behind that. I was wrong about Grapefruit in a thread last spring and I would…	+44	48	12k	18mo
Swirling versus inverting versus leaving it alone Practice › Reconstitution concentration maths syringe units bacteriostatic water reconstitution On the subject in the title: Swirling versus inverting versus leaving it alone Working notes rather than a conclusion. Asking about swirling versus inverting versus leaving on behalf of the question I keep…		2	18k	18mo
Follow-up: Oral contraceptives and delayed emptying: what the data shows Practice › Interactions hypoglycaemia delayed gastric emptying needs a source Closed Oral contraceptives and delayed emptying: what the data shows — setting out what I have, and where I think it stops being reliable. A follow-up question about Oral contraceptives and delayed emptying that I…	+31	35	13k	18mo
Follow-up: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration tirzepatide dose reduction worked example missed dose Wiki Where the four-week escalation interval comes from, and what it is not Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about four-week escalation…	+131	147	47k	18mo
Converting between mg/mL and units per dose, both directions Practice › Reconstitution concentration maths dead volume bacteriostatic water Solved Posting this under the heading it deserves: Converting between mg/mL and units per dose, both directions Everything below is what sits behind that. Practical question with the units stated, because I have…	+106	142	9.5k	19mo
Injection-site reactions: describing them precisely enough to be useful Practice › Side effects nausea delayed gastric emptying vomiting fatigue Injection-site reactions: describing them precisely enough to be useful Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on…	+81	86	3.6k	19mo