Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later.
I would rather say I do not know than round it up to an answer.
3 likes 3mo
Evidence · Journal club · continued
Journal club: SURMOUNT-4 and continuation versus withdrawal posts 31–37
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
Post #28 put the caveat in the right place and I want to underline it.
Whatever the answer on SURMOUNT-4 and continuation versus withdrawal turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite the correction.
11 likes 3mo
Collapsed as off-topic by two members at trust level 3 or above
The version of SURMOUNT-4 and continuation versus withdrawal that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was.
tracked_parcel, post #23: The most useful reply I ever got about SURMOUNT-4 and continuation versus withdrawal was a request to state my units. It sounds like pedantry and it has saved me twice. Go to post
The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.
Taking post #34 at face value and following it one step further.
I have been on both sides of the SURMOUNT-4 and continuation versus withdrawal argument in this category within eighteen months, which should tell you how strong the evidence for either side is.
1 like 3mo
unit_conversion, post #21: I had written a reply contradicting post #19 and deleted it. Here is what survived. The baseline characteristics table is the single most useful page for the questions that get asked here, because it tells you who the result applies to. Reporting the observation and leaving the explanation open deliberately. Go to post
Marking my place. If it changes for me I will come back and say so.
This topic was referenced in
- About the Journal club categoryEvidence › Journal club · 6 replies
- Journal club: LEADER as the historical anchorEvidence › Journal club · 110 replies
- [2026 update] Journal club: what we got wrong in an earlier sessionEvidence › Journal club · 9 replies
Suggested topics
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Journal club: SUSTAIN 6 and its retinopathy signal
On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…
|
+110 | 122 | 46k | 1d |
|
Journal club: the retatrutide phase 2 obesity paper
Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. Collecting what is known about retatrutide phase 2 obesity paper in one place, because…
|
+7 | 11 | 33k | 7mo |
|
Journal club: what we got wrong in an earlier session
On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Bringing a claim rather than a paper, because the claim is the thing circulating. The…
|
+114 | 125 | 2.5k | 23h |
|
Journal club: STEP 4 and what a withdrawal design can prove
On the subject in the title: Journal club: STEP 4 and what a withdrawal design can prove Working notes rather than a conclusion. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…
|
+61 | 65 | 2k | 13mo |
|
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset
Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Posting a small dataset on SURMOUNT-4 and…
|
+58 | 64 | 17k | 13mo |
Related topics — sharing the tags journal club, number needed to treat, effect size
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Citing a preprint in a maintained document: our rule and its reasoning
On the subject in the title: Citing a preprint in a maintained document: our rule and its reasoning Working notes rather than a conclusion. A preprint question rather than a question about the finding in it.…
|
2 | 467 | 4mo | |
|
Coming back to: A critique that turned out to be unfair, retracted by its author
A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about critique, three…
|
2 | 1.3k | 14mo | |
|
Second pass at: Historical amylin analogues and what happened to them
Second pass at: Historical amylin analogues and what happened to them — setting out what I have, and where I think it stops being reliable. The question about Historical amylin analogues that I actually want…
|
+15 | 19 | 22k | 18mo |
|
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper
Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Retatrutide phase 2 in type that I did…
|
+1 | 5 | 31k | 8mo |
|
Follow-up: Is "synergy" the right word for the combination data?
Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below. Putting the numbers in the first post, because a question about…
|
2 | 41k | 14mo |