Topic summary
Journal club: SURMOUNT-4 and continuation versus withdrawal
This is a generated summary. It shows the 5 most-liked posts from a topic of 37, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
Worth separating two things that post #7 runs together.
The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions.
22 likes 4mo
b.restrepo, post #9: Worth separating two things that post #7 runs together. The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. Go to post
Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then abstract last. Reading the abstract first anchors everything that follows.
It is worth checking rather than assuming, which costs nothing.
I had written a reply contradicting post #19 and deleted it. Here is what survived.
The baseline characteristics table is the single most useful page for the questions that get asked here, because it tells you who the result applies to.
Reporting the observation and leaving the explanation open deliberately.
30 likes 4mo
unit_conversion, post #21: I had written a reply contradicting post #19 and deleted it. Here is what survived. The baseline characteristics table is the single most useful page for the questions that get asked here, because it tells you who the result applies to. Reporting the observation and leaving the explanation open deliberately. Go to post
Marking my place. If it changes for me I will come back and say so.
Read the full topic (37 posts)
This topic was referenced in
- About the Journal club categoryEvidence › Journal club · 6 replies
- Journal club: LEADER as the historical anchorEvidence › Journal club · 110 replies
- [2026 update] Journal club: what we got wrong in an earlier sessionEvidence › Journal club · 9 replies
Suggested topics
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Journal club: SUSTAIN 6 and its retinopathy signal
On the subject in the title: Journal club: SUSTAIN 6 and its retinopathy signal Working notes rather than a conclusion. Reading SUSTAIN 6 ( N Engl J Med , 2016) for the population rather than the effect,…
|
+110 | 122 | 46k | 1d |
|
Journal club: the retatrutide phase 2 obesity paper
Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. Collecting what is known about retatrutide phase 2 obesity paper in one place, because…
|
+7 | 11 | 33k | 7mo |
|
Journal club: what we got wrong in an earlier session
On the subject in the title: Journal club: what we got wrong in an earlier session Working notes rather than a conclusion. Bringing a claim rather than a paper, because the claim is the thing circulating. The…
|
+114 | 125 | 2.5k | 23h |
|
Journal club: STEP 4 and what a withdrawal design can prove
On the subject in the title: Journal club: STEP 4 and what a withdrawal design can prove Working notes rather than a conclusion. Session topic: STEP 4 ( JAMA , 2021). Please read it before posting; the…
|
+61 | 65 | 2k | 13mo |
|
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset
Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that. Posting a small dataset on SURMOUNT-4 and…
|
+58 | 64 | 17k | 13mo |
Related topics — sharing the tags journal club, number needed to treat, effect size
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Citing a preprint in a maintained document: our rule and its reasoning
On the subject in the title: Citing a preprint in a maintained document: our rule and its reasoning Working notes rather than a conclusion. A preprint question rather than a question about the finding in it.…
|
2 | 467 | 4mo | |
|
Coming back to: A critique that turned out to be unfair, retracted by its author
A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about critique, three…
|
2 | 1.3k | 14mo | |
|
Second pass at: Historical amylin analogues and what happened to them
Second pass at: Historical amylin analogues and what happened to them — setting out what I have, and where I think it stops being reliable. The question about Historical amylin analogues that I actually want…
|
+15 | 19 | 22k | 18mo |
|
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper
Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Retatrutide phase 2 in type that I did…
|
+1 | 5 | 31k | 8mo |
|
Follow-up: Is "synergy" the right word for the combination data?
Is "synergy" the right word for the combination data? I have a specific reason for asking rather than idle curiosity, and the context is below. Putting the numbers in the first post, because a question about…
|
2 | 41k | 14mo |