Ranked by engagement

Top topics — all time page 11

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 11 of 40

Topic	Participants	Replies	Views	Activity
SURPASS-2 and the comparator dose question that will not go away Compounds › Tirzepatide SURPASS programme randomised trial effect size SURMOUNT programme SURPASS-2 and the comparator dose question that will not go away — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about SURPASS-2.…	+101	111	1.5k	18mo
Journal club: LEADER as the historical anchor Evidence › Journal club estimand number needed to treat journal club effect size Pinned Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of LEADER is wrong? I ask because I have…	+103	110	8.1k	2h
MHRA statements, read directly Regional › UK & Ireland NHS MHRA personal import Solved Pinned MHRA statements, read directly Writing it up because I had to work it out twice and would rather nobody else did. Asking about MHRA statements directly, because I have read four threads on it and each…	+93	101	2.2k	5mo
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand effect size risk of bias journal club Solved On the subject in the title: Journal club: SURPASS-2 and the semaglutide 1 mg comparator Working notes rather than a conclusion. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it before posting;…	+71	76	52k	21mo
Coming back to: Training through a dose escalation week Nutrition & Training › Resistance training fatigue lean mass loss DXA On the subject in the title: Training through a dose escalation week Working notes rather than a conclusion. What changes if the standard account of Training through a dose escalation is wrong? I ask because…	+68	74	46k	4mo
Persistent vomiting and the threshold for seeking help Safety › Adverse events vomiting hypoglycaemia gallbladder pancreatitis On the subject in the title: Persistent vomiting and the threshold for seeking help Working notes rather than a conclusion. Trying to work out what would count as evidence on persistent vomiting, before…	+82	88	31k	7mo
Second pass at: Certificates issued by the seller versus by a laboratory Analytics › COA interpretation certificate of analysis amino acid analysis batch & lot numbers Second pass at: Certificates issued by the seller versus by a laboratory — setting out what I have, and where I think it stops being reliable. Two reports on the same lot, and I would like help deciding…	+81	92	20k	18mo
GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology semaglutide amylin analogues retatrutide long read Posting this under the heading it deserves: GLP-1 receptor distribution: central and peripheral Everything below is what sits behind that. I have spent a fortnight trying to pin GLP-1 receptor distribution…	+90	98	30k	22h
A 40-week log with the measurement method stated Outcomes › Progress reports DXA long read data table On the subject in the title: A 40-week log with the measurement method stated Working notes rather than a conclusion. Asking about 40-week log directly, because I have read four threads on it and each…	+87	97	18k	9mo
[2026 update] What a purity-only report leaves out Sourcing › Independent verification PeptideMeter third-party testing Janoshik Analytical The question in the title: What a purity-only report leaves out I will give what I have already checked below so nobody repeats it. Structured report rather than an opinion, following the format the…	+97	103	5.2k	3mo
Muscle cramps: the ordinary causes before the exotic ones Practice › Side effects vomiting delayed gastric emptying nausea fatigue Closed Muscle cramps: the ordinary causes before the exotic ones Writing it up because I had to work it out twice and would rather nobody else did. Proposing that muscle cramps deserves a maintained page rather than…	+80	90	27k	6mo
Carryover and the ghost peak from last week's standard Analytics › HPLC & UHPLC data table UV & DAD detection peak integration system suitability On the subject in the title: Carryover and the ghost peak from last week's standard Working notes rather than a conclusion. What changes if the standard account of carryover is wrong? I ask because I have…	+80	92	16k	16mo
Constipation management, with a dietitian's contribution Practice › Side effects constipation nausea delayed gastric emptying vomiting Solved Posting this under the heading it deserves: Constipation management, with a dietitian's contribution Everything below is what sits behind that. Constipation management: setting out the arithmetic in full,…	+79	88	27k	21d
Criticising the method without criticising the authors Evidence › Study critique disputed observational data confounding effect size Criticising the method without criticising the authors Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about criticising the method without criticising in a…	+55	61	60k	15mo
Pharmacy supply in the UK and the questions you will be asked Regional › UK & Ireland personal import cost per milligram MHRA NHS On the subject in the title: Pharmacy supply in the UK and the questions you will be asked Working notes rather than a conclusion. Asking about pharmacy supply on behalf of the question I keep seeing asked…	+95	105	1.3k	4mo
Antibiotics and a course of something with delayed emptying Practice › Interactions insulin hypoglycaemia needs a source metformin Antibiotics and a course of something with delayed emptying — setting out what I have, and where I think it stops being reliable. Something about antibiotics does not reconcile and I would like a second pair…	+99	108	1.4k	12mo
A supplier who responds to a discrepancy with silence — what changed since Sourcing › Red flags mislabelling disputed documentation quality underdosing Wiki A supplier who responds to a discrepancy with silence — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of supplier is wrong? I…	+83	88	21k	6h
What a purity-only report leaves out Sourcing › Independent verification Medutest VendorInvestigate third-party testing PeptideMeter Solved What a purity-only report leaves out — that is the question, and I have not found it answered plainly anywhere I have looked. Purity-only: setting out the arithmetic in full, because I have had to do it twice…	+92	105	4k	8mo
How to ask for a dose change without antagonising anyone — what changed since Clinical › Prescriber conversations prior authorisation telehealth type 2 diabetes Solved How to ask for a dose change without antagonising anyone — what changed since — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how to describe…	+81	92	10k	20mo
Second pass at: Sleep apnoea improving and the equipment implications Wellbeing › Sleep fatigue heart rate obstructive sleep apnoea On the subject in the title: Second pass at: Sleep apnoea improving and the equipment implications Working notes rather than a conclusion. Asking about sleep specifically, and trying to keep it separate from…	+89	96	1.1k	10h
Power cut for eleven hours: how I assessed it afterwards Practice › Storage & stability beyond-use date freeze-thaw storage cloudy or discoloured solution Posting this under the heading it deserves: Power cut for eleven hours: how I assessed it afterwards Everything below is what sits behind that. The question about power cut for eleven hours that I actually…	+102	109	1.4k	9mo
Follow-up: Prior authorisation: what the criteria usually require Access › Insurance & coverage insurance appeals formulary prior authorisation Solved Prior authorisation: what the criteria usually require — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about Prior authorisation.…	+95	100	9.1k	10h
Telehealth prescribing models in the US Regional › North America FDA compounding insurance telehealth Telehealth prescribing models in the US Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on telehealth prescribing models,…	+95	102	6.1k	14mo
A parcel stationary at a customs facility for nine days Sourcing › Logistics customs packaging cold chain temperature excursion On the subject in the title: A parcel stationary at a customs facility for nine days Working notes rather than a conclusion. A logistics question, since the answers here are usually better than anywhere else…	+64	72	51k	1mo
Citation sweep results: how many references did not say what was claimed Meta › Wiki maintenance moderation maintainership citation check wiki post On the subject in the title: Citation sweep results: how many references did not say what was claimed Working notes rather than a conclusion. What changes if the standard account of citation sweep results is…	+92	101	2.9k	2mo
Stability of BPC-157 in solution: what has been measured — one year on Compounds › Repair & healing peptides needs a source observational data preprint BPC-157 On the subject in the title: Stability of BPC-157 in solution: what has been measured — one year on Working notes rather than a conclusion. A narrow question about Stability of BPC-157, deliberately narrow,…	+84	98	7.8k	18h
Follow-up: History of disordered eating and why it changes the conversation Clinical › Special populations bariatric surgery history older adults pregnancy & planning chronic kidney disease Posting this under the heading it deserves: History of disordered eating and why it changes the conversation Everything below is what sits behind that. What changes if the standard account of History of…	+75	81	23k	10mo
Prescription requirements and telehealth models Sourcing › Regulatory FDA compounding research use only MHRA Prescription requirements and telehealth models Writing it up because I had to work it out twice and would rather nobody else did. Proposing that prescription requirements and telehealth models deserves a…	+91	97	5.4k	7mo
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Practice › Side effects constipation delayed gastric emptying fatigue hair shedding Solved Posting this under the heading it deserves: Muscle cramps: the ordinary causes before the exotic ones — a second dataset Everything below is what sits behind that. Something about Muscle cramps does not…	+65	77	39k	1d
Follow-up: Journal club: orforglipron phase 2 and the non-peptide question Evidence › Journal club randomised trial risk of bias effect size number needed to treat Posting this under the heading it deserves: Journal club: orforglipron phase 2 and the non-peptide question Everything below is what sits behind that. A follow-up question about orforglipron phase 2 that I…	+80	91	10k	11mo