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Top topics — all time page 18

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 18 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: Conditions that change the calculus rather than forbidding it Safety › Contraindications pancreatitis disordered eating thyroid C-cell question pregnancy & planning Posting this under the heading it deserves: Conditions that change the calculus rather than forbidding it Everything below is what sits behind that. I was wrong about Conditions in a thread last spring and I…	+30	34	62k	2y
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club randomised trial risk of bias effect size journal club Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…	+70	76	4.8k	15h
Bioimpedance and hydration: why the number moves Outcomes › Body composition lean mass loss data table DXA bioimpedance Bioimpedance and hydration: why the number moves — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin bioimpedance and hydration down and I want to set…	+62	70	13k	23d
Checking someone else's arithmetic: a worked example thread Practice › Reconstitution reconstitution syringe units concentration maths worked example Checking someone else's arithmetic: a worked example thread Writing it up because I had to work it out twice and would rather nobody else did. Practical question with the units stated, because I have seen how…	+74	78	895	11mo
Regression to the mean in progress reports Research Methods › Statistics number needed to treat heterogeneity confounding effect size On the subject in the title: Regression to the mean in progress reports Working notes rather than a conclusion. Something about regression does not reconcile and I would like a second pair of eyes before I…	+30	34	49k	12mo
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter Practice › Interactions hypoglycaemia metformin insulin needs a source Solved Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…	+63	74	11k	1d
A 10 mg vial reconstituted three different ways, compared Practice › Reconstitution bacteriostatic water worked example concentration maths Posting this under the heading it deserves: A 10 mg vial reconstituted three different ways, compared Everything below is what sits behind that. Something about 10 mg vial reconstituted three does not…	+30	34	55k	17h
Washout: how long is long enough, and for what purpose Pharmacology › Pharmacokinetics semaglutide missed dose worked example Closed Washout: how long is long enough, and for what purpose — setting out what I have, and where I think it stops being reliable. A narrow question about washout, deliberately narrow, because the broad version has…	+63	70	13k	10mo
A calculator that gives a right answer to the wrong question — does this still hold? Data & Tools › Calculators worked example concentration maths syringe units site feedback Solved Under review A calculator that gives a right answer to the wrong question — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the calculation with the…	+23	27	62k	8mo
What I would record differently if I started again — the long version Outcomes › Progress reports effect size data table DXA Solved Closed What I would record differently if I started again — the long version I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about the phase almost nobody writes…	+22	26	57k	5mo
Peak-to-trough ratio at steady state for a weekly agent Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example missed dose Solved On the subject in the title: Peak-to-trough ratio at steady state for a weekly agent Working notes rather than a conclusion. Working through the kinetics rather than the pharmacology, because I think the…	+58	64	9.7k	2mo
Pages past their review date, listed — does this still hold? Meta › Wiki maintenance review date moderation citation check maintainership Solved Closed Pages past their review date, listed — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to disagree carefully with the settled view…	+27	31	52k	15mo
Revisiting: PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities type 2 diabetes obstructive sleep apnoea PCOS Revisiting: PCOS and metabolic overlap: what is and is not studied — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on PCOS and metabolic…	+55	59	26k	2d
Second pass at: How to research a compound with no human data without deceiving yourself Compounds › Other compounds research use only custom synthesis needs a source mislabelling Second pass at: How to research a compound with no human data without deceiving yourself Writing it up because I had to work it out twice and would rather nobody else did. The question about research a…	+64	71	2.5k	13mo
Lipase elevation without symptoms: the interpretation problem Clinical › Bloodwork thyroid function lipase & amylase eGFR & renal function Pinned Closed Lipase elevation without symptoms: the interpretation problem Writing it up because I had to work it out twice and would rather nobody else did. Lipase elevation without symptoms — I have the observation and…	+21	25	62k	5mo
Pooling trials with different estimands — what changed since Evidence › Meta-analyses publication bias risk of bias meta-analysis effect size Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Pooling trials with different…	+57	64	12k	7mo
Revisiting: GLP-1 receptor distribution: central and peripheral Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+61	66	15k	8mo
Publishing an inconvenient result: a case study Sourcing › Independent verification Medutest VendorInvestigate third-party testing Janoshik Analytical Wiki On the subject in the title: Publishing an inconvenient result: a case study Working notes rather than a conclusion. Publishing an inconvenient result, and specifically the version of it that the…	+59	70	992	11mo
Follow-up: How compounding permissions changed when supply normalised Sourcing › Regulatory MHRA personal import research use only How compounding permissions changed when supply normalised I have a specific reason for asking rather than idle curiosity, and the context is below. I was wrong about compounding permissions in a thread last…	+72	77	1.5k	1d
Coming back to: A structured critique template this community uses Evidence › Study critique confounding risk of bias disputed observational data Posting this under the heading it deserves: A structured critique template this community uses Everything below is what sits behind that. Reading back through what has been written here about structured…	+63	69	17k	18h
Tirzepatide molecular mass and the charge states you would expect on ESI Compounds › Tirzepatide effect size SURPASS programme SURMOUNT programme randomised trial Tirzepatide molecular mass and the charge states you would expect on ESI Writing it up because I had to work it out twice and would rather nobody else did. Tirzepatide molecular mass keeps being re-asked here…	+36	40	44k	11mo
Fibre intake when total intake falls, and the constipation link Nutrition & Training › Protein & intake lean mass loss fatigue constipation micronutrients Fibre intake when total intake falls, and the constipation link — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on fibre intake. The general…	+61	66	12k	15mo
Sample handling between despatch and injection Analytics › Method validation stability-indicating method LOD & LOQ linearity precision & repeatability Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on sample handling between…	+63	68	2.4k	3mo
The best-written scientific paper you have read Lounge › Off topic long read beginner friendly The best-written scientific paper you have read Writing it up because I had to work it out twice and would rather nobody else did. Asking about best-written scientific paper directly, because I have read four…	+69	74	1.1k	2mo
Talking to a therapist about this specifically — does this still hold? Wellbeing › Mental health mood disordered eating beginner friendly Solved The question in the title: Talking to a therapist about this specifically — does this still hold? I will give what I have already checked below so nobody repeats it. A question about the part of this that…	+59	65	13k	14mo
Request: export my own posts — one year on Meta › Feature requests site feedback wiki post translation Request: export my own posts — one year on — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about export. Everyone quotes the same figure…	+61	70	14k	4mo
EMA product information as a primary source Regional › European Union personal import formulary EMA Posting this under the heading it deserves: EMA product information as a primary source Everything below is what sits behind that. Something about EMA product information does not reconcile and I would like a…	+70	74	7k	8mo
Splitting a vial for two laboratories: how to do it without ruining both Sourcing › Independent verification blind sampling PeptideMeter third-party testing Medutest Solved Splitting a vial for two laboratories: how to do it without ruining both — setting out what I have, and where I think it stops being reliable. Something about splitting a vial does not reconcile and I would…	+64	70	4.4k	13mo
What to include when your question involves a chromatogram — one year on Start Here › How to Ask worked example guidelines site feedback onboarding Asking directly, because I could not find a straight answer: What to include when your question involves a chromatogram — one year on Question in the title. Context below, and I have tried to include the…	+69	75	862	14d
Revisiting: Mean kinetic temperature explained without the mathematics Practice › Storage & stability storage cold chain temperature excursion cloudy or discoloured solution Solved Revisiting: Mean kinetic temperature explained without the mathematics Writing it up because I had to work it out twice and would rather nobody else did. A methods question rather than a substantive one,…	+67	75	909	2mo