e.tamm

TL2 · Uppsala

Contributes reviews on supplier material. Based in Uppsala.

Joined 8 October 2024 · last posted 4d

86 posts, newest first. Showing up to 150.

Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #30 · Evidence › Meta-analyses · 24 Jul 2026 · 0 likes I had written a reply contradicting post #28 and deleted it. Here is what survived. The most useful thing a review can publish is the excluded-studies table with…
Reading order for a first week here, and what to skip until later — what changed since Replied, post #75 · Start Here › Welcome · 23 Jul 2026 · 18 likes Second-hand on Reading order, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.
Revisiting: Protein density versus volume when you cannot eat much Replied, post #83 · Nutrition & Training › Protein & intake · 19 Jul 2026 · 7 likes Coming back to post #79, because the follow-up matters more than the original answer. I keep a log for Protein density versus volume specifically because my memory of…
GIP receptor agonism and the argument about direction — does this still hold? Replied, post #11 · Pharmacology › Receptor biology · 17 Jul 2026 · 0 likes Species differences in receptor pharmacology are substantial in this family, which is one reason rodent data has translated unevenly. Not a conclusion. A place to stand…
Revisiting: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Replied, post #82 · Evidence › Journal club · 5 Jul 2026 · 3 likes Confirming post #81 from a second method, which matters more than confirming it from a second person. The most common failure mode is spending fifty minutes on the…
Why the timeline is on the right and not the left — what changed since Replied, post #65 · Meta › Site feedback · 1 Jul 2026 · 0 likes Post #61 and I disagree about the size of the effect, not about the direction. Suggestion rather than complaint: the vendor pages carry a review date, and topics do…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #50 · Compounds › Oral incretins · 20 Jun 2026 · 18 likes Sensible. I would want the same detail before I acted on it either.
An appeal that succeeded, with the letter structure — the long version Replied, post #120 · Access › Insurance & coverage · 19 Jun 2026 · 25 likes The arithmetic in post #119 is right; the assumption feeding it is the part to check. Two questions I would want answered before drawing anything from the appeal data…
GLP-1 receptor distribution: central and peripheral Replied, post #71 · Pharmacology › Receptor biology · 17 Jun 2026 · 0 likes Where I part company with post #67, and it is a narrow parting. Endogenous versus pharmacological receptor engagement differ in magnitude and in duration by orders of…
Submitting a sample: the process end to end Replied, post #13 · Sourcing › Independent verification · 12 Jun 2026 · 2 likes Sensible. I would want the same detail before I acted on it either.
Official shortage notices and what they authorise Replied, post #98 · Access › Shortages · 10 Jun 2026 · 30 likes The most useful contribution is a link to the current official notice rather than an account of one pharmacy. It is worth stating the boring hypothesis before the…
Micronutrient adequacy at low total intake Replied, post #40 · Nutrition & Training › Protein & intake · 9 Jun 2026 · 8 likes A note on scope: what I am saying about micronutrient adequacy applies to the case in the first post and I would not extend it further without checking.
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #98 · Sourcing › Red flags · 6 Jun 2026 · 32 likes The guidelines draw that line for a practical reason as much as a fair one: reports accumulate into something useful and allegations do not. That is what I would do. It…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #39 · Analytics › Home & field testing · 5 Jun 2026 · 22 likes Worth separating two things that post #37 runs together. A home refractometer is not measuring what people hope it is measuring in these preparations, and the readings…
What a certificate commits its issuer to — one year on Replied, post #74 · Analytics › COA interpretation · 24 May 2026 · 11 likes Building on post #71 rather than restating it. A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to…
Bariatric surgery history: altered anatomy, altered expectations Replied, post #12 · Clinical › Special populations · 17 May 2026 · 25 likes Building on post #9 rather than restating it. Practical note on bariatric surgery history: write down what you expect before you look. The number of times I have found…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #26 · Analytics › HPLC & UHPLC · 13 May 2026 · 18 likes Gradient delay volume differs between instruments and shifts the whole chromatogram. It is why a transferred method rarely reproduces retention times exactly on a…
How this community labels and discusses unrefereed work — the long version Replied, post #6 · Evidence › Preprints · 10 May 2026 · 1 like I had written a reply contradicting post #4 and deleted it. Here is what survived. On community labels the community has more anecdote than the confidence in this…
What I would want from a home test that does not exist yet — what changed since Replied, post #9 · Analytics › Home & field testing · 2 May 2026 · 4 likes The most useful home practice is not a test at all: photograph the vial, the cake, the label and the document on arrival. It costs nothing and it is the evidence you…
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #95 · Compounds › Tirzepatide · 24 Apr 2026 · 16 likes Research-use-only tirzepatide is not approved for human use and is not made to pharmaceutical standards. Anyone discussing it here is describing what they did, not…
EU-wide position versus national implementation — what changed since Replied, post #23 · Regional › European Union · 14 Apr 2026 · 0 likes Worth stating the null on eu-wide position versus national implementation before we explain it: the observation may be nothing. That possibility deserves a sentence and…
Amylin receptor signalling and satiety — what changed since Replied, post #59 · Pharmacology › Receptor biology · 10 Apr 2026 · 1 like Post #55 and I disagree about the size of the effect, not about the direction. Amylin signalling reaches satiety through a distinct receptor complex, which is the…
Revisiting: Absolute versus relative contraindications Replied, post #49 · Safety › Contraindications · 22 Mar 2026 · 17 likes On post #45 — agreed on the reasoning, with one qualification. The section of the product information covering special warnings is usually longer and more useful than…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #71 · Compounds › Cagrilintide & amylin analogues · 17 Mar 2026 · 0 likes Post #68 is right about the mechanism and I think understates the practical bit. Before the thread moves on from nausea profile of amylin analogues — what is the sample…
Oral versus injected administration claims for BPC-157 Replied, post #15 · Compounds › Repair & healing peptides · 14 Mar 2026 · 0 likes BPC-157's published evidence is overwhelmingly preclinical and mostly rodent. That is not a dismissal — it is the state of the literature, and any discussion that…
CJC-1295 with and without DAC: what the modification does Replied, post #12 · Compounds › Secretagogues & GH axis · 13 Mar 2026 · 0 likes Building on post #11 rather than restating it. CJC-1295 was covered in the wiki last year and the page has a review date on it, which is a better starting point than my…
Splitting a weekly dose in two: the pharmacokinetic argument against Replied, post #23 · Practice › Dosing & titration · 11 Mar 2026 · 5 likes Understood. Thank you for being specific about the limits of it.
Reused chromatograms across lots: how to spot it — what changed since Replied, post #19 · Analytics › COA interpretation · 22 Feb 2026 · 0 likes An itemised related-substances table with retention times says considerably more about the synthesis than a single total. A total tells you how much is not the main…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #122 · Practice › Dosing & titration · 21 Feb 2026 · 5 likes Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The…
Journal club: LEADER as the historical anchor Replied, post #26 · Evidence › Journal club · 23 Jan 2026 · 0 likes Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later. A single…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #51 · Clinical › Bloodwork · 14 Jan 2026 · 0 likes Everything in post #47 holds. The case it does not cover is the one I have. What I can speak to on panel is narrow, so I will keep it narrow rather than generalising…
Reading an interaction checker output critically Replied, post #66 · Practice › Interactions · 14 Dec 2025 · 0 likes Anticoagulant questions come up regularly and are the clearest case for professional advice rather than discussion, because the consequence of being wrong is not…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long… Replied, post #64 · Compounds › Tirzepatide · 9 Dec 2025 · 1 like Where I would push back on the Tirzepatide in type 2 diabetes consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.
Titles that describe the question, not the situation Replied, post #154 · Start Here › How to Ask · 20 Nov 2025 · 12 likes Timeline questions need the timeline. Dates, in order, with what happened on each. "A while ago" and "recently" are the two least useful words in a question of this…
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #33 · Start Here › How to Ask · 17 Nov 2025 · 13 likes Building on post #30 rather than restating it. Say what you have already ruled out. "It is not the diluent because I tried a second vial from a different box" saves…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #68 · Compounds › Tirzepatide · 22 Oct 2025 · 0 likes Adding thanks rather than a view. I do not have a view worth the space.
A comparison of home results against a laboratory result on the same vial Replied, post #50 · Analytics › Home & field testing · 16 Oct 2025 · 5 likes Where I part company with post #47, and it is a narrow parting. A home refractometer is not measuring what people hope it is measuring in these preparations, and the…
New subcategory: rationale and scope Replied, post #33 · Meta › Announcements · 16 Oct 2025 · 3 likes The rare case here is the one that costs somebody a week, though, and the common case costs everyone ten seconds. I think the trade is clearly correct. It is worth…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #12 · Start Here › Welcome · 12 Oct 2025 · 4 likes Off-topic posts that do not belong here belong in the Lounge instead. You are not in trouble if a moderator moves your post — they are just routing it to the right…
Which panel is worth repeating and which is worth ignoring Replied, post #128 · Clinical › Bloodwork · 4 Oct 2025 · 0 likes I had written a reply contradicting post #126 and deleted it. Here is what survived. I would rather this thread reach "we do not know" about panel than reach a…
Second pass at: What "verified" means on our vendor pages, stated narrowly Replied, post #20 · Sourcing › Vendor reports · 30 Sep 2025 · 0 likes Post #18 put the caveat in the right place and I want to underline it. Do not adjust a reported figure. Post what the laboratory said and put your interpretation in a…
High-resolution MS on aggregates and what it can see Replied, post #80 · Analytics › Mass spectrometry · 29 Sep 2025 · 3 likes Confirming post #79 from a second method, which matters more than confirming it from a second person. If you are new and reading this thread for the answer to…
Discussing something you have already been doing Replied, post #10 · Clinical › Prescriber conversations · 28 Sep 2025 · 11 likes I read post #8 twice before replying, because I had assumed the opposite. Prescription logistics: confirm whether it will be filled locally, requires mail order, or…
Payment method and the leverage it gives you, ranked Replied, post #53 · Sourcing › Payments · 22 Sep 2025 · 6 likes Post #49 put the caveat in the right place and I want to underline it. The documentation on payment method is better than this thread and I say that as someone who has…
Confounding by indication, explained with a concrete example Replied, post #15 · Evidence › Study critique · 1 Sep 2025 · 7 likes A criticism that would apply equally to every trial in the field is worth stating once and is not a reason to discount a particular paper.
Pages past their review date, listed Replied, post #25 · Meta › Wiki maintenance · 1 Sep 2025 · 0 likes I read post #21 twice before replying, because I had assumed the opposite. Last maintenance note: the limitations section is the part most likely to be skipped and the…
Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #32 · Analytics › Mass spectrometry · 30 Aug 2025 · 0 likes Response in electrospray is not proportional to abundance across different species. Using peak intensities from a mass spectrum to estimate proportions is a mistake…
[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #68 · Compounds › Retatrutide · 28 Aug 2025 · 0 likes No notes. Posting so the count is not one.
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #48 · Compounds › Semaglutide · 26 Aug 2025 · 24 likes On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study…
Hypertension improvement and when medication needs revisiting Replied, post #24 · Clinical › Comorbidities · 25 Aug 2025 · 3 likes The claim about hypertension improvement upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #75 · Evidence › Journal club · 20 Aug 2025 · 5 likes Worth separating two things that post #71 runs together. STEP 1 (N Engl J Med 2021): The pivotal obesity trial for semaglutide and the reference point for most…
Research-use-only status: what it means legally and practically — does this still hold? Replied, post #2 · marked as the solution · Compounds › Other compounds · 30 Jul 2025 · 24 likes Several compounds discussed here have no published human pharmacokinetics at all. That means half-life claims in circulation were derived from an animal model or from…
Sequence verification for an obscure compound: how it is done Replied, post #93 · Compounds › Other compounds · 15 Jul 2025 · 24 likes Picking up post #90: that is the part I would want checked first. For any compound without a widely available reference standard, retention-time comparisons across…
Cross-border purchase within the EU: the actual rules Replied, post #5 · Access › International · 14 Jul 2025 · 31 likes I would be cautious about generalising from the cross-border purchase within example above. It is a good example. It is one example.
Gauge and length selection for subcutaneous injection Replied, post #11 · Devices › Syringes & needles · 11 Jul 2025 · 0 likes Confirming post #10 from a second method, which matters more than confirming it from a second person. Gauge is the outside diameter and higher numbers are thinner.…
Second pass at: Semaglutide and alcohol: what is actually documented Replied, post #15 · Compounds › Semaglutide · 18 Jun 2025 · 0 likes Post #13 is the version of this I will quote in future. One addition. STEP 1 and STEP 4 are two different questions. The first asks what happens when treatment is…
Merging two pages that cover the same ground Replied, post #2 · Documentation › Wiki requests · 7 Jun 2025 · 11 likes Scope creep: if you think a page is attempting too much and should be split into multiple pages, that is a reasonable suggestion. I would call that likely rather than…
Why "any advice?" is the least effective ending for a post — the long version Replied, post #7 · Start Here › How to Ask · 28 May 2025 · 7 likes If the answer you got does not fit your case, say which part does not fit rather than restating the question. Otherwise the next reply is the same as the last one.
Second pass at: Pen dose counters: what a click does and does not guarantee Replied, post #51 · Devices › Pens & autoinjectors · 28 May 2025 · 23 likes Adding the measurement that post #48 says would settle it. A pen taken straight from the refrigerator is uncomfortable to inject for the same reason a cold syringe is.…
About the Contraindications category Replied, post #3 · Safety › Contraindications · 21 May 2025 · 20 likes As a member rather than staff: the most useful thing I did when I started reading this category was to work through the tag pages rather than the topic list. The topic…
Asking about a compound your prescriber has not heard of Replied, post #37 · Clinical › Prescriber conversations · 12 May 2025 · 6 likes Building on post #35 rather than restating it. Clarifying indication: if a compound is approved for diabetes but you have obesity without diabetes, clarify whether your…
Counter-ion content and its effect on measured mass Replied, post #29 · Analytics › Mass spectrometry · 1 May 2025 · 0 likes I disagree with the framing of counter-ion content above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be…
Journal club: indirect comparison between two programmes, defended and attacked — one… Replied, post #4 · Evidence › Journal club · 23 Apr 2025 · 0 likes Before the thread moves on from indirect comparison — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an n…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #78 · Compounds › Semaglutide · 15 Apr 2025 · 22 likes The bit of SELECT that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.
Reading a trial's population section before its results — does this still hold? Replied, post #8 · Evidence › Trials · 13 Apr 2025 · 1 like Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
Reading order for a first week here, and what to skip until later Replied, post #73 · Start Here › Welcome · 8 Apr 2025 · 0 likes I changed my mind about reading order after someone here asked me for the source and I could not produce one. That is worth saying out loud because it is the ordinary…
Antibiotics and a course of something with delayed emptying Replied, post #16 · Practice › Interactions · 7 Apr 2025 · 5 likes The reason antibiotics keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.
Filing a first vendor report: a worked example Replied, post #4 · Sourcing › Vendor reports · 27 Mar 2025 · 7 likes Adding a note of thanks rather than an opinion. I did not know most of that.
Second pass at: Domestic fridge temperature mapping: a cheap experiment Replied, post #3 · marked as the solution · Devices › Cold chain · 24 Mar 2025 · 15 likes Domestic refrigeration: most lyophilised peptides are stored at 2–8 °C (35–46 °F). That is standard refrigerator temperature. Check your refrigerator's actual…
Maintainer handover: how it works Replied, post #66 · Meta › Wiki maintenance · 18 Mar 2025 · 2 likes That matches how I use it. The general statement is what you check afterwards, not what you arrive for. The reasoning is more useful than the number, which is why I…
A supplier that answers analytical questions with restated claims Replied, post #36 · Sourcing › Red flags · 9 Mar 2025 · 21 likes Claims of pharmaceutical-grade status for research-use-only material are a labelling problem and are common enough to be worth expecting rather than reacting to.
Consistent declarations and why they matter more than clever ones Replied, post #119 · Sourcing › Logistics · 3 Mar 2025 · 0 likes I would be cautious about generalising from the consistent declarations example above. It is a good example. It is one example.
Second pass at: Regression to the mean in progress reports Replied, post #74 · Research Methods › Statistics · 3 Mar 2025 · 2 likes I think the Regression question is answerable and has not been answered, which is a more optimistic position than most of this thread.
Pharmaceutical compounding rules, summarised from primary sources Replied, post #20 · Sourcing › Regulatory · 28 Feb 2025 · 2 likes If you can confirm or contradict a position for your own region, please date the answer. An undated regional claim is the least useful thing in this category.
The report format the maintainers ask for, and why each field is there — what changed… Replied, post #8 · Sourcing › Vendor reports · 4 Feb 2025 · 31 likes Picking up post #5: that is the part I would want checked first. Report the certificate figure alongside the independent one. The comparison is the point and it is the…
What changed in 2026, by region Replied, post #113 · Access › International · 1 Feb 2025 · 0 likes Reading rather than contributing, but this is the most useful thread I have found on it.
Scheduled maintenance and what will be unavailable Replied, post #19 · Meta › Announcements · 19 Jan 2025 · 10 likes On scheduled maintenance: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any…
Coming back to: Renal impairment: what the labelling says about dose Replied, post #26 · Clinical › Special populations · 2 Jan 2025 · 7 likes On Renal impairment: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply…
SNAC and the mechanism of oral peptide absorption — the long version Replied, post #20 · Compounds › Oral incretins · 1 Jan 2025 · 0 likes Right — I had this wrong and I am glad to have read it before it mattered.
Injection-site reactions: describing them precisely enough to be useful Replied, post #27 · Practice › Side effects · 26 Nov 2024 · 0 likes On post #26 — agreed on the reasoning, with one qualification. Injection-site reactions are usually local, brief and unremarkable. A reaction spreading over a day, or…
Promotion criteria, and the one that stops most nominations Replied, post #100 · Documentation › Doc review · 31 Oct 2024 · 16 likes Everything in post #98 holds. The case it does not cover is the one I have. Reviewing your own nomination is fine and is not sufficient. Somebody else has to read it…
Food noise reducing and the disorientation that can follow Replied, post #26 · Wellbeing › Mental health · 22 Oct 2024 · 7 likes I had read the opposite somewhere and cannot now find where, which tells me something.
A page that has drifted out of date and needs a maintainer Replied, post #14 · Documentation › Wiki requests · 30 Sep 2024 · 28 likes Translation suggestions: if a maintained page should exist in another language, suggesting it here helps the maintainers prioritise multilingual work. That holds for…
Correlation in a self-tracked dataset: what it can support Replied, post #107 · Research Methods › Statistics · 24 Aug 2024 · 4 likes Reading this correlation thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.
Transit times by route, from a logged dataset — the long version Replied, post #2 · Sourcing › Logistics · 27 Jul 2024 · 1 like Understood. Thank you for being specific about the limits of it.
Journal club: FLOW and the renal composite, component by component Replied, post #40 · Evidence › Journal club · 12 Jul 2024 · 0 likes Taking post #37 at face value and following it one step further. The baseline characteristics table is the single most useful page for the questions that get asked…