Follow-up: Where the four-week escalation interval comes from, and what it is not

I had written a reply contradicting post #8 and deleted it. Here is what survived.

Splitting a weekly dose in two: the pharmacokinetic argument against is that you want the benefit of long half-life, which gives a slowly changing plasma level from a weekly dosing schedule. Splitting it flattens the curve further but loses the convenience of once-weekly dosing. The trade-off is convenience versus a slightly flatter concentration curve.

Same conclusion as the reply above, reached differently, which is mildly reassuring.

Building on post #32 rather than restating it.

Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.

I have no financial interest in anything named in this thread and I want to say so before I comment on four-week escalation interval, because it is the sort of subject where it matters.

I read post #43 twice before replying, because I had assumed the opposite.

Adding a small correction to the four-week escalation interval summary above rather than a disagreement with it. The substance holds; one of the figures is out by a factor that matters.

I had written a reply contradicting post #83 and deleted it. Here is what survived.

Dose and effect are not linear across the studied range for every compound in this class. Assuming a doubled dose gives a doubled effect is the reasoning error behind most disappointment.

A note on scope: what I am saying about four-week escalation interval applies to the case in the first post and I would not extend it further without checking.

Post #109 and I disagree about the size of the effect, not about the direction.

Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.

Scoping that to what I have actually seen rather than what I have read.

Post #117 is the version of this I will quote in future. One addition.

I would be cautious about generalising from the four-week escalation interval example above. It is a good example. It is one example.

Acknowledging rather than arguing. The reasoning holds as far as I can follow it.