Ranked by engagement

Top topics — all time page 14

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 14 of 40

Topic	Participants	Replies	Views	Activity
Transit times by route, from a logged dataset — the long version Sourcing › Logistics cold chain shipping customs Wiki Closed Posting this under the heading it deserves: Transit times by route, from a logged dataset — the long version Everything below is what sits behind that. A narrow question about Transit times, deliberately…	+82	87	8.9k	15mo
Documentation that materially improves an appeal's chances Access › Insurance & coverage insurance appeals formulary prior authorisation Documentation that materially improves an appeal's chances — setting out what I have, and where I think it stops being reliable. An honest uncertainty about documentation rather than a disguised assertion. I…	+93	98	3.6k	8mo
Reading a rodent study on a secretagogue without over-extrapolating — the long version Compounds › Secretagogues & GH axis observational data tesamorelin ipamorelin needs a source Reading a rodent study on a secretagogue without over-extrapolating — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Reading a rodent study,…	+59	66	30k	4h
Pen mechanics when the cartridge is nearly empty — does this still hold? Devices › Pens & autoinjectors storage subcutaneous injection missed dose dead volume Asking directly, because I could not find a straight answer: Pen mechanics when the cartridge is nearly empty — does this still hold? Pen mechanics — I have the observation and I do not trust my…	+37	47	61k	6mo
Why a compound being unapproved is not the same as being illegal to possess Sourcing › Regulatory FDA MHRA research use only EMA Why a compound being unapproved is not the same as being illegal to possess I have a specific reason for asking rather than idle curiosity, and the context is below. Collecting what is known about compound…	+72	78	23k	3mo
Adolescents: a distinct evidence base — one year on Clinical › Special populations bariatric surgery history disordered eating pregnancy & planning adolescents Pinned Wiki Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. A methods question rather than a substantive one, about Adolescents.…	+78	88	9.3k	3mo
Injection discomfort: needle gauge, volume, temperature, technique Practice › Administration subcutaneous injection injection site reaction needle gauge & length aseptic technique Injection discomfort: needle gauge, volume, temperature, technique — setting out what I have, and where I think it stops being reliable. Injection discomfort: setting out the arithmetic in full, because I…	+66	71	14k	2mo
Pre-registering a personal experiment, seriously — a second dataset Research Methods › N-of-1 designs data table worked example confounding Posting this under the heading it deserves: Pre-registering a personal experiment, seriously — a second dataset Everything below is what sits behind that. Posting a small dataset on Pre-registering a personal…	+60	66	35k	3mo
An 18-month record including the parts that went badly Outcomes › Progress reports data table long read effect size DXA An 18-month record including the parts that went badly — setting out what I have, and where I think it stops being reliable. Asking about 18-month record on behalf of the question I keep seeing asked badly,…	+77	81	17k	12h
Coming back to: Sample size calculations, read backwards from the published number Evidence › Trials estimand discontinuation & dropout surrogate endpoints randomised trial On the subject in the title: Sample size calculations, read backwards from the published number Working notes rather than a conclusion. Sample size calculations — I have the observation and I do not trust my…	+82	88	1.8k	11mo
Distinguishing a deletion sequence by mass alone — the long version Analytics › Mass spectrometry high-resolution MS mass error (ppm) charge states MALDI-TOF On the subject in the title: Distinguishing a deletion sequence by mass alone — the long version Working notes rather than a conclusion. A narrow question about Distinguishing a deletion sequence,…	+38	44	60k	11mo
Detection wavelength and why 214 nm and 280 nm disagree Analytics › HPLC & UHPLC peak integration UV & DAD detection system suitability HPLC On the subject in the title: Detection wavelength and why 214 nm and 280 nm disagree Working notes rather than a conclusion. I would like to disagree carefully with the settled view on detection wavelength,…	+78	84	1.7k	8mo
Realistic expectations for strength while losing weight quickly Nutrition & Training › Resistance training fatigue DXA lean mass loss Closed Posting this under the heading it deserves: Realistic expectations for strength while losing weight quickly Everything below is what sits behind that. Working notes on realistic expectations for strength…	+60	70	38k	4mo
Hypertension improvement and when medication needs revisiting Clinical › Comorbidities type 2 diabetes MASH / hepatic steatosis chronic kidney disease Closed Hypertension improvement and when medication needs revisiting Writing it up because I had to work it out twice and would rather nobody else did. Hypertension improvement: setting out the arithmetic in full,…	+74	79	1.1k	10mo
How to read a forest plot, properly, from scratch Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Solved The question in the title: How to read a forest plot, properly, from scratch I will give what I have already checked below so nobody repeats it. Reading STEP 4 ( JAMA , 2021) for the population rather than…	+73	81	17k	7mo
Coverage for the indication versus for the drug — a second dataset Access › Insurance & coverage prior authorisation appeals formulary insurance Solved Closed On the subject in the title: Coverage for the indication versus for the drug — a second dataset Working notes rather than a conclusion. Posting a small dataset on Coverage. It is mine, it is uncontrolled, and…	+46	50	41k	16mo
DXA precision and the least significant change for lean mass Outcomes › Body composition bioimpedance data table DXA Closed Posting this under the heading it deserves: DXA precision and the least significant change for lean mass Everything below is what sits behind that. A question about measurement precision rather than about…	+81	85	2.7k	7mo
Oxidation and deamidation mass shifts, tabulated Analytics › Mass spectrometry counter-ion content charge states LC-MS mass error (ppm) Solved Posting this under the heading it deserves: Oxidation and deamidation mass shifts, tabulated Everything below is what sits behind that. Oxidation and deamidation mass shifts, and specifically the version of…	+67	76	21k	16mo
Reflectance and photometric devices: precision in practice — a second dataset Analytics › Home & field testing ELISA LOD & LOQ documentation quality Reflectance and photometric devices: precision in practice — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Reflectance and photometric…	+75	82	17k	12h
Tracking that stops updating and then resumes — the long version Sourcing › Logistics packaging cold chain shipping Tracking that stops updating and then resumes — the long version — setting out what I have, and where I think it stops being reliable. A logistics question, since the answers here are usually better than…	+61	69	27k	6mo
A comparison of home results against a laboratory result on the same vial Analytics › Home & field testing documentation quality ELISA third-party testing Posting this under the heading it deserves: A comparison of home results against a laboratory result on the same vial Everything below is what sits behind that. Comparison of home results against: setting out…	+61	65	35k	8mo
Availability by country, dated, with primary sources Access › International EMA MHRA telehealth personal import On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+72	81	6.9k	8mo
Fasting versus non-fasting and which tests care Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c Solved Fasting versus non-fasting and which tests care Writing it up because I had to work it out twice and would rather nobody else did. Fasting versus non-fasting: what I expected, what I found, and the gap…	+72	78	14k	19h
A history of disordered eating: proceeding carefully Wellbeing › Mental health mood beginner friendly disordered eating A history of disordered eating: proceeding carefully Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view on history of…	+70	75	10k	6mo
Recovery when intake is low: what to cut first Nutrition & Training › Resistance training lean mass loss DXA fatigue Recovery when intake is low: what to cut first Writing it up because I had to work it out twice and would rather nobody else did. Question about training and intake together, because separating them has not…	+85	91	1.2k	18mo
Coverage for the indication versus for the drug Access › Insurance & coverage insurance formulary appeals prior authorisation Coverage for the indication versus for the drug — setting out what I have, and where I think it stops being reliable. The question about coverage that I actually want answered is the second one below. The…	+70	79	18k	14mo
Follow-up: A site rotation scheme that is easy enough to actually follow Practice › Administration subcutaneous injection injection site reaction injection site rotation aseptic technique A site rotation scheme that is easy enough to actually follow Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about site rotation scheme that I did not…	+81	89	3.8k	22mo
Freeze-thaw and why one cycle is not the same as five — a second dataset Practice › Storage & stability storage beyond-use date freeze-thaw Freeze-thaw and why one cycle is not the same as five — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Freeze-thaw. It is mine, it is…	+47	55	46k	10mo
Follow-up: Sleep quality changes during weight loss Wellbeing › Sleep fatigue obstructive sleep apnoea heart rate On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. A follow-up question about Sleep quality changes during weight that I did not know to ask the…	+74	80	4.4k	14h
What a documentation review can and cannot tell you Sourcing › Independent verification Medutest VendorInvestigate Janoshik Analytical blind sampling Solved Wiki What a documentation review can and cannot tell you — that is the question, and I have not found it answered plainly anywhere I have looked. Something about documentation review does not reconcile and I would…	+79	83	950	11mo