Ranked by engagement

Top topics — all time page 15

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 15 of 40

Topic	Participants	Replies	Views	Activity
Pages past their review date, listed — does this still hold? Meta › Wiki maintenance review date moderation maintainership wiki post Asking directly, because I could not find a straight answer: Pages past their review date, listed — does this still hold? I have spent a fortnight trying to pin Pages past down and I want to set out where I…	+49	56	39k	11d
Revisiting: Absolute versus relative contraindications Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Revisiting: Absolute versus relative contraindications — setting out what I have, and where I think it stops being reliable. A narrow question about Absolute versus relative contraindications, deliberately…	+80	85	7.4k	3mo
Comparators chosen for regulatory reasons rather than clinical ones — one year on Evidence › Trials randomised trial intention to treat open label estimand Solved Comparators chosen for regulatory reasons rather than clinical ones — one year on — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Comparators chosen for…	+82	87	1.1k	12mo
[2026 update] Composite endpoints and the component doing the work Evidence › Trials surrogate endpoints discontinuation & dropout estimand On the subject in the title: Composite endpoints and the component doing the work Working notes rather than a conclusion. Comparing SURMOUNT-1 ( N Engl J Med , 2022) with SURPASS-4 ( Lancet , 2021) and…	+76	87	994	3mo
[2026 update] Thyroid function tests during substantial weight change Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c thyroid function Thyroid function tests during substantial weight change Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Thyroid function tests during…	+69	74	4.5k	2mo
Why the timeline is on the right and not the left — what changed since Meta › Site feedback site feedback moderation guidelines Solved Why the timeline is on the right and not the left — what changed since I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of…	+77	81	4k	2d
Why semaglutide solutions can look faintly opalescent and when that matters Compounds › Semaglutide semaglutide SELECT trial randomised trial effect size Solved The question in the title: Why semaglutide solutions can look faintly opalescent and when that matters I will give what I have already checked below so nobody repeats it. A follow-up question about…	+73	79	2k	4mo
How to ask a question when you cannot say why you are asking it Start Here › How to Ask beginner friendly site feedback worked example onboarding Solved Asking directly, because I could not find a straight answer: How to ask a question when you cannot say why you are asking it Question in the title. Context below, and I have tried to include the things people…	+49	53	36k	4h
Primary endpoint hierarchies and why order matters — one year on Evidence › Trials surrogate endpoints discontinuation & dropout estimand randomised trial Solved On the subject in the title: Primary endpoint hierarchies and why order matters — one year on Working notes rather than a conclusion. A follow-up question about Primary endpoint hierarchies that I did not…	+56	61	37k	11h
Comparing my trajectory with the trial curves, carefully — a second dataset Outcomes › Progress reports effect size data table long read Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather than loss, which is the part of this that…	+77	81	16k	11h
Packaging that arrived damaged: documenting it properly — a second dataset Sourcing › Logistics customs shipping temperature excursion Posting this under the heading it deserves: Packaging that arrived damaged: documenting it properly — a second dataset Everything below is what sits behind that. A logistics question, since the answers here…	+68	73	20k	4mo
Why mass spectrometry cannot tell you about an epimer Analytics › Mass spectrometry LC-MS mass error (ppm) high-resolution MS charge states Why mass spectrometry cannot tell you about an epimer I have a specific reason for asking rather than idle curiosity, and the context is below. I have spent a fortnight trying to pin mass spectrometry down…	+75	82	4k	17mo
Revisiting: Liver enzymes drifting down and what that usually means Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase On the subject in the title: Revisiting: Liver enzymes drifting down and what that usually means Working notes rather than a conclusion. A methods question rather than a substantive one, about Liver enzymes…	+55	61	39k	3h
Designing a personal experiment that could change your mind — one year on Research Methods › N-of-1 designs effect size data table worked example Designing a personal experiment that could change your mind — one year on — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on…	+74	80	17k	2d
Liver enzymes drifting down and what that usually means Clinical › Bloodwork HbA1c liver enzymes eGFR & renal function Solved Closed Liver enzymes drifting down and what that usually means — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about liver enzymes drifting.…	+66	72	12k	4mo
What to bring: records that a clinician can actually use — a second dataset Clinical › Prescriber conversations telehealth beginner friendly prior authorisation What to bring: records that a clinician can actually use — a second dataset I have a specific reason for asking rather than idle curiosity, and the context is below. A question about how to describe something…	+80	86	5.6k	3h
Injection-site reactions: describing them precisely enough to be useful Practice › Side effects nausea delayed gastric emptying vomiting fatigue Injection-site reactions: describing them precisely enough to be useful Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on…	+81	86	3.6k	19mo
Canadian access and provincial variation Regional › North America compounding telehealth FDA insurance Posting this under the heading it deserves: Canadian access and provincial variation Everything below is what sits behind that. Trying to establish the boundary conditions on canadian access and provincial…	+74	80	7.7k	18mo
Pinch or no pinch, and how needle length changes the answer — the long version Practice › Administration injection site rotation injection site reaction missed dose aseptic technique On the subject in the title: Pinch or no pinch, and how needle length changes the answer — the long version Working notes rather than a conclusion. A narrow question about Pinch, deliberately narrow, because…	+75	79	1.5k	1mo
Micro-titration: a disputed topic, argued properly — one year on Practice › Dosing & titration dose reduction missed dose semaglutide Posting this under the heading it deserves: Micro-titration: a disputed topic, argued properly — one year on Everything below is what sits behind that. Reading back through what has been written here about…	+63	68	35k	1d
Prescription requirements and telehealth models — a second dataset Sourcing › Regulatory compounding EMA MHRA personal import On the subject in the title: Prescription requirements and telehealth models — a second dataset Working notes rather than a conclusion. Posting a small dataset on Prescription requirements and telehealth…	+87	94	1.1k	21d
A claim built entirely on a subgroup analysis Evidence › Study critique risk of bias observational data confounding disputed Solved A claim built entirely on a subgroup analysis Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view on claim built, and I…	+71	80	1.1k	14mo
Pinch or no pinch, and how needle length changes the answer — what changed since Practice › Administration missed dose aseptic technique injection site rotation Solved Posting this under the heading it deserves: Pinch or no pinch, and how needle length changes the answer — what changed since Everything below is what sits behind that. What changes if the standard account of…	+58	62	16k	1d
Why catalogue breadth is not evidence of anything — what changed since Compounds › Other compounds custom synthesis mislabelling needs a source research use only Asking directly, because I could not find a straight answer: Why catalogue breadth is not evidence of anything — what changed since What changes if the standard account of catalogue breadth is wrong? I ask…	+62	66	26k	10mo
Journal club: STEP 4 and what a withdrawal design can prove — one year on Evidence › Journal club number needed to treat estimand randomised trial effect size Closed Journal club: STEP 4 and what a withdrawal design can prove — one year on Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 4 ( JAMA , 2021). Please read…	+56	62	34k	15mo
Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators worked example site feedback syringe units concentration maths Bug report: the reconstitution calculator and a rounding edge case — setting out what I have, and where I think it stops being reliable. Posting the calculation with the inputs, so that somebody can disagree…	+68	72	28k	4mo
A revision dispute resolved on the topic rather than in the history — a second dataset Meta › Wiki maintenance moderation citation check maintainership wiki post Solved On the subject in the title: A revision dispute resolved on the topic rather than in the history — a second dataset Working notes rather than a conclusion. Posting a small dataset on revision dispute…	+45	50	33k	20mo
Journal club: the CagriSema phase 2 combination paper — a second dataset Evidence › Journal club journal club estimand effect size Solved Journal club: the CagriSema phase 2 combination paper — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on CagriSema phase 2 combination paper.…	+74	79	2.3k	13mo
Does a peptide degrade silently, with no visual change? Practice › Storage & stability beyond-use date cold chain temperature excursion freeze-thaw Solved Does a peptide degrade silently, with no visual change? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of peptide is wrong? I…	+73	79	1.3k	1d
Why the absence of controlled human data on BPC-157 matters more than people admit Compounds › Repair & healing peptides needs a source BPC-157 preprint Solved Why the absence of controlled human data on BPC-157 matters more than people admit — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to know what people…	+60	66	16k	1d