Ranked by engagement

Top topics — all time page 22

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,535 topics · page 22 of 40

Topic	Participants	Replies	Views	Activity
Coming back to: Private prescribing in the UK: what is actually involved Regional › UK & Ireland personal import MHRA NHS cost per milligram Private prescribing in the UK: what is actually involved Writing it up because I had to work it out twice and would rather nobody else did. I would like to know what people here actually do about Private…	+62	67	2.1k	6mo
Gastro-oesophageal reflux: improving or worsening? Clinical › Comorbidities PCOS obstructive sleep apnoea MASH / hepatic steatosis chronic kidney disease Solved The question in the title: Gastro-oesophageal reflux: improving or worsening? I will give what I have already checked below so nobody repeats it. Collecting what is known about gastro-oesophageal reflux in…	+54	58	8.2k	1mo
Journal club: SURMOUNT-4 and continuation versus withdrawal Evidence › Journal club journal club number needed to treat effect size Journal club: SURMOUNT-4 and continuation versus withdrawal — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on SURMOUNT-4 and continuation…	+32	36	31k	3mo
Coming back to: Preparing for an appointment: one page, three questions Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes prior authorisation Preparing for an appointment: one page, three questions — setting out what I have, and where I think it stops being reliable. A question about how to describe something to a clinician rather than about the…	+51	56	1.4k	2d
Specificity, linearity, accuracy, precision, range, robustness — with real criteria Analytics › Method validation precision & repeatability LOD & LOQ linearity Specificity, linearity, accuracy, precision, range, robustness — with real criteria Writing it up because I had to work it out twice and would rather nobody else did. Trying to establish the boundary…	+44	48	12k	1d
IGF-1 as a surrogate endpoint and its limitations — the long version Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved Closed On the subject in the title: IGF-1 as a surrogate endpoint and its limitations — the long version Working notes rather than a conclusion. A narrow question about IGF-1, deliberately narrow, because the broad…	+14	18	53k	12mo
Discussing something you have already been doing — the long version Clinical › Prescriber conversations telehealth prior authorisation beginner friendly type 2 diabetes Solved Discussing something you have already been doing — the long version Writing it up because I had to work it out twice and would rather nobody else did. A question about how to describe something to a clinician…	+14	18	58k	12mo
Travel coolers and how long they really hold — the long version Devices › Cold chain storage freeze-thaw cold chain Solved Pinned Travel coolers and how long they really hold — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Travel coolers, deliberately narrow, because the…	+19	23	45k	14mo
Gauge and length selection for subcutaneous injection Devices › Syringes & needles syringe units needle gauge & length worked example subcutaneous injection Solved Gauge and length selection for subcutaneous injection Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about gauge and length selection that I did not…	+50	55	1.3k	8mo
Interim analyses and stopping rules — does this still hold? Evidence › Trials estimand discontinuation & dropout open label surrogate endpoints Solved Interim analyses and stopping rules — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Interim analyses and stopping rules, from the point of view…	+30	34	29k	13mo
Food noise reducing and the disorientation that can follow Wellbeing › Mental health beginner friendly mood disordered eating Pinned Posting this under the heading it deserves: Food noise reducing and the disorientation that can follow Everything below is what sits behind that. A follow-up question about food noise that I did not know to…	+40	45	8.9k	20mo
[2026 update] Amylin and gastric emptying: overlapping mechanisms with incretins Compounds › Cagrilintide & amylin analogues amylin analogues randomised trial effect size cagrisema Amylin and gastric emptying: overlapping mechanisms with incretins — setting out what I have, and where I think it stops being reliable. A question about Amylin and gastric emptying that I think has a…	+21	25	44k	5mo
Second pass at: Gauge and length selection for subcutaneous injection Devices › Syringes & needles subcutaneous injection syringe units worked example needle gauge & length Posting this under the heading it deserves: Second pass at: Gauge and length selection for subcutaneous injection Everything below is what sits behind that. The question about Gauge and length selection that…	+50	58	14k	15mo
Tracking that stops updating and then resumes Sourcing › Logistics customs temperature excursion cold chain shipping Solved On the subject in the title: Tracking that stops updating and then resumes Working notes rather than a conclusion. A logistics question, since the answers here are usually better than anywhere else I have…	+58	62	1.9k	7mo
[2026 update] Long-time reader, first-time poster Lounge › Introductions onboarding beginner friendly Solved Long-time reader, first-time poster — setting out what I have, and where I think it stops being reliable. Saying hello, and stating my interest so that it is on the record rather than inferred. I am here for…	+46	50	23k	5mo
How much fluid is actually needed, and how you would know Nutrition & Training › Hydration & electrolytes heart rate blood pressure fatigue Solved The question in the title: How much fluid is actually needed, and how you would know I will give what I have already checked below so nobody repeats it. Reporting what I changed and what happened, with the…	+11	15	53k	2mo
Ipamorelin selectivity claims and where they came from Compounds › Secretagogues & GH axis GHRP class tesamorelin ipamorelin Closed Ipamorelin selectivity claims and where they came from — setting out what I have, and where I think it stops being reliable. Ipamorelin selectivity claims, from the point of view of someone who has read the…	+51	56	8.8k	12mo
Reading SURMOUNT-1 without the press release — one year on Compounds › Tirzepatide effect size SURPASS programme randomised trial Solved Closed Reading SURMOUNT-1 without the press release — one year on — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on Reading SURMOUNT-1…	+45	50	7.6k	5mo
[2026 update] A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipase & amylase liver enzymes lipid panel Solved Closed On the subject in the title: A single out-of-range value on an otherwise normal panel Working notes rather than a conclusion. General question, not a request for advice about my own care — I know the…	+15	19	53k	9mo
Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides BPC-157 observational data preprint TB-500 Oral versus injected administration claims for BPC-157 — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin oral versus injected administration claims…	+20	24	47k	4mo
[2026 update] Lipid changes during rapid weight loss: the expected trajectory Clinical › Bloodwork thyroid function eGFR & renal function lipid panel lipase & amylase Lipid changes during rapid weight loss: the expected trajectory Writing it up because I had to work it out twice and would rather nobody else did. Lipid changes during rapid weight keeps being re-asked here…	+51	56	7.1k	17mo
[2026 update] Availability by country, dated, with primary sources Access › International MHRA NHS telehealth personal import On the subject in the title: Availability by country, dated, with primary sources Working notes rather than a conclusion. Documenting an access outcome, dated, because everything in this category expires. As…	+40	45	14k	4mo
Prediction intervals and why they are more honest than confidence intervals Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Closed Posting this under the heading it deserves: Prediction intervals and why they are more honest than confidence intervals Everything below is what sits behind that. I have spent a fortnight trying to pin…	+21	25	46k	4mo
Follow-up: Constipation management, with a dietitian's contribution Practice › Side effects nausea fatigue hair shedding Closed Constipation management, with a dietitian's contribution — setting out what I have, and where I think it stops being reliable. A follow-up question about Constipation management that I did not know to ask the…	+31	35	28k	8mo
Coming back to: Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration dose reduction semaglutide titration tirzepatide Solved Posting this under the heading it deserves: Where the four-week escalation interval comes from, and what it is not Everything below is what sits behind that. Four-week escalation interval — I have the…	+44	48	11k	1d
A certificate with no method stated: what can you conclude? Analytics › COA interpretation certificate of analysis batch & lot numbers documentation quality Solved A certificate with no method stated: what can you conclude? I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to understand what this number means before I…	+49	57	1.2k	16mo
Coming back to: Solubility limits and what a cloudy solution is telling you Pharmacology › Formulation chemistry sterile water cloudy or discoloured solution storage counter-ion content On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. Reading back through what has been written here about Solubility limits, three…	+38	43	29k	13h
High-resolution MS on aggregates and what it can see — one year on Analytics › Mass spectrometry LC-MS counter-ion content MALDI-TOF charge states Solved High-resolution MS on aggregates and what it can see — one year on Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about High-resolution, deliberately…	+54	58	1.2k	23mo
Which categories are strict and which are relaxed, honestly Start Here › Welcome onboarding beginner friendly guidelines trust levels Solved Which categories are strict and which are relaxed, honestly I have a specific reason for asking rather than idle curiosity, and the context is below. I want to check my reasoning rather than get a conclusion.…	+46	53	1.8k	2d
What I would want from a home test that does not exist yet Analytics › Home & field testing ELISA documentation quality LOD & LOQ Solved Pinned The question in the title: What I would want from a home test that does not exist yet I will give what I have already checked below so nobody repeats it. Two reports on the same lot, and I would like help…	+46	50	8k	6h