Ranked by engagement

Top topics — all time page 23

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,535 topics · page 23 of 40

Topic	Participants	Replies	Views	Activity
A plateau that disappeared when I changed how I measured — the long version Outcomes › Progress reports effect size data table long read A plateau that disappeared when I changed how I measured — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about plateau, deliberately narrow, because…	+49	54	9.4k	1mo
Coming back to: Grapefruit: why this class is not the class that cares Practice › Interactions metformin needs a source insulin Posting this under the heading it deserves: Grapefruit: why this class is not the class that cares Everything below is what sits behind that. I was wrong about Grapefruit in a thread last spring and I would…	+44	48	12k	18mo
The C-cell question: rodent findings and their human context Compounds › Semaglutide STEP programme type 2 diabetes effect size Closed Posting this under the heading it deserves: The C-cell question: rodent findings and their human context Everything below is what sits behind that. The question about c-cell question that I actually want…	+41	45	24k	12mo
Second pass at: What a 2 ppm match establishes, and what it does not Analytics › Mass spectrometry MALDI-TOF mass error (ppm) counter-ion content high-resolution MS Second pass at: What a 2 ppm match establishes, and what it does not — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on 2 ppm…	+44	49	8.1k	1d
The "under review" status pill and when a moderator applies it — a second dataset Evidence › Preprints needs a source risk of bias preprint effect size The "under review" status pill and when a moderator applies it — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. A question about how this site should cite…	+50	54	1.4k	11mo
Freeze-thaw and why one cycle is not the same as five Practice › Storage & stability beyond-use date freeze-thaw cloudy or discoloured solution storage On the subject in the title: Freeze-thaw and why one cycle is not the same as five Working notes rather than a conclusion. Two things I would like separated before anyone answers on freeze-thaw, because they…	+21	25	41k	8mo
Hepatic impairment and the absence of data Clinical › Special populations older adults adolescents chronic kidney disease disordered eating Hepatic impairment and the absence of data — setting out what I have, and where I think it stops being reliable. I was wrong about hepatic impairment in a thread last spring and I would like to correct it…	+30	35	32k	10mo
Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC peak integration system suitability UV & DAD detection gradient method Solved Closed Posting this under the heading it deserves: Comparing two chromatograms from different laboratories, properly Everything below is what sits behind that. I would like to understand what this number means…	+35	40	22k	7mo
[2026 update] Splitting an overlong document into two Documentation › Wiki requests maintainership review date wiki post promoted to docs Solved Closed Splitting an overlong document into two — setting out what I have, and where I think it stops being reliable. Collecting what is known about Splitting an overlong document in one place, because it is…	+44	48	7k	9mo
Units, standards, and other things that quietly hold the world together Lounge › Off topic long read beginner friendly Closed Units, standards, and other things that quietly hold the world together — setting out what I have, and where I think it stops being reliable. I was wrong about units in a thread last spring and I would like…	+33	38	31k	15mo
Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide randomised trial preprint effect size retatrutide Solved Closed On the subject in the title: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Working notes rather than a conclusion. Asking about retatrutide phase 2 in type on behalf of the question I keep seeing…	+12	16	50k	12mo
Immortal time bias in a claims-database study Evidence › Study critique risk of bias observational data disputed confounding Closed Immortal time bias in a claims-database study — setting out what I have, and where I think it stops being reliable. Asking about immortal time bias directly, because I have read four threads on it and each…	+29	34	28k	11mo
Batch numbers that do not match the vial label — what changed since Sourcing › Red flags underdosing documentation quality disputed moderation Solved On the subject in the title: Batch numbers that do not match the vial label — what changed since Working notes rather than a conclusion. What changes if the standard account of Batch numbers is wrong? I ask…	+39	43	14k	1mo
Second pass at: Food noise reducing and the disorientation that can follow Wellbeing › Mental health beginner friendly disordered eating mood Closed Second pass at: Food noise reducing and the disorientation that can follow — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on Food…	+55	59	965	21mo
Second pass at: When your prescriber and the evidence disagree Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth prior authorisation Pinned Second pass at: When your prescriber and the evidence disagree — setting out what I have, and where I think it stops being reliable. What changes if the standard account of prescriber is wrong? I ask because…	+51	55	9.2k	2d
Coming back to: Payment method and the leverage it gives you, ranked Sourcing › Payments payments documentation quality research use only Payment method and the leverage it gives you, ranked — setting out what I have, and where I think it stops being reliable. A payments question, with the mechanics separated from the money. What I would like…	+21	26	43k	2d
GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Compounds › Secretagogues & GH axis CJC-1295 observational data ipamorelin needs a source Solved On the subject in the title: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated discussion Working notes rather than a conclusion. Asking about GHRH analogues versus ghrelin mimetics…	+47	53	6.9k	2h
Cross-border purchase rules within the EU Regional › European Union personal import formulary cost per milligram EMA On the subject in the title: Cross-border purchase rules within the EU Working notes rather than a conclusion. The question about cross-border purchase rules within that I actually want answered is the second…	+45	49	15k	8mo
Non-inferiority margins: how they are chosen and how they are abused Evidence › Trials open label surrogate endpoints estimand intention to treat Posting this under the heading it deserves: Non-inferiority margins: how they are chosen and how they are abused Everything below is what sits behind that. A question about non-inferiority margins that I…	+42	46	10k	5mo
eGFR fluctuation and the creatinine denominator problem — the long version Clinical › Bloodwork thyroid function eGFR & renal function liver enzymes lipase & amylase Under review eGFR fluctuation and the creatinine denominator problem — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about egfr fluctuation, deliberately narrow,…	+43	47	17k	just now
[2026 update] Journal club: PIONEER 6 as a safety trial Evidence › Journal club journal club number needed to treat estimand Journal club: PIONEER 6 as a safety trial Writing it up because I had to work it out twice and would rather nobody else did. Bringing a claim rather than a paper, because the claim is the thing circulating.…	+14	18	55k	5mo
State-level differences that actually matter Regional › North America compounding telehealth insurance FDA Solved On the subject in the title: State-level differences that actually matter Working notes rather than a conclusion. The question about state-level differences that I actually want answered is the second one…	+6	10	56k	10mo
Request: tag synonyms surfaced in search Meta › Feature requests wiki post translation site feedback Solved On the subject in the title: Request: tag synonyms surfaced in search Working notes rather than a conclusion. A follow-up question about tag synonyms surfaced in search that I did not know to ask the first…	+23	27	38k	3h
Pancreatitis history and the risk calculus — a second dataset Safety › Contraindications thyroid C-cell question disordered eating pancreatitis Pancreatitis history and the risk calculus — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Pancreatitis history. It is mine, it…	+24	28	36k	16mo
Restarting after a long gap: what the labelling implies Practice › Dosing & titration dose reduction semaglutide titration missed dose Posting this under the heading it deserves: Restarting after a long gap: what the labelling implies Everything below is what sits behind that. I have read the maintained page on this and I still have a gap,…	+41	46	11k	15h
Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide amylin analogues Closed Amylin analogue mechanism: satiety signalling separate from GLP-1 — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Trying to work out what would…	+21	25	45k	7mo
A critique that turned out to be unfair, retracted by its author Evidence › Study critique confounding risk of bias effect size observational data Wiki Posting this under the heading it deserves: A critique that turned out to be unfair, retracted by its author Everything below is what sits behind that. Critique, and specifically the version of it that the…	+34	38	20k	17h
Severe gastroparesis and why this class is a poor fit Safety › Contraindications pancreatitis pregnancy & planning delayed gastric emptying Solved On the subject in the title: Severe gastroparesis and why this class is a poor fit Working notes rather than a conclusion. I was wrong about severe gastroparesis in a thread last spring and I would like to…		3	62k	13mo
Coming back to: Recording a dissent on a document rather than suppressing it Documentation › Doc review promoted to docs review date wiki post maintainership Posting this under the heading it deserves: Recording a dissent on a document rather than suppressing it Everything below is what sits behind that. Recording a dissent, and specifically the version of it that…	+43	47	11k	16mo
What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? Compounds › Retatrutide randomised trial effect size TRIUMPH programme retatrutide Solved Asking directly, because I could not find a straight answer: What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still hold? An honest uncertainty about TRIUMPH rather than a…	+43	47	5.5k	just now