Ranked by engagement

Top topics — all time page 27

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 27 of 40

Topic	Participants	Replies	Views	Activity
About the Storage & stability category Practice › Storage & stability storage temperature excursion cold chain Pinned Wiki Refrigeration, excursions, light exposure, freeze-thaw, beyond-use dating, and what published stability data actually covers. This post is a community wiki: any member at trust level 3 or above can edit it,…		4	57k	4mo
How shortages have affected compounding permissions — does this still hold? Access › Shortages compounding shortage formulary FDA Solved How shortages have affected compounding permissions — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about shortages directly, because I…	+27	31	21k	17h
SNAC and the mechanism of oral peptide absorption — the long version Compounds › Oral incretins oral semaglutide randomised trial orforglipron SNAC and the mechanism of oral peptide absorption — the long version Writing it up because I had to work it out twice and would rather nobody else did. Question about what the published evidence for this…	+32	36	6.8k	16mo
About the Home & field testing category Analytics › Home & field testing ELISA third-party testing LOD & LOQ Pinned Wiki What consumer-accessible tests can and cannot tell you. Mostly a subcategory about limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…		4	51k	11mo
What a stability-indicating method is and how you demonstrate one Analytics › Method validation linearity precision & repeatability LOD & LOQ Asking directly, because I could not find a straight answer: What a stability-indicating method is and how you demonstrate one Posting a small dataset on stability-indicating method. It is mine, it is…		4	57k	6mo
Air bubbles in a subcutaneous injection: the honest risk assessment — does this still hold? Practice › Administration injection site rotation missed dose aseptic technique subcutaneous injection Wiki Asking directly, because I could not find a straight answer: Air bubbles in a subcutaneous injection: the honest risk assessment — does this still hold? An honest uncertainty about Air bubbles rather than a…	+21	30	20k	4mo
Reconstituting a multi-strength kit without mixing yourself up — what changed since Practice › Reconstitution concentration maths syringe units bacteriostatic water On the subject in the title: Reconstituting a multi-strength kit without mixing yourself up — what changed since Working notes rather than a conclusion. What changes if the standard account of Reconstituting…	+42	46	1k	7h
Trial registration and comparing the protocol with the paper Evidence › Trials randomised trial open label intention to treat Trial registration and comparing the protocol with the paper — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin trial registration down and I want to…	+38	44	4.8k	10mo
[2026 update] EU-wide position versus national implementation Regional › European Union personal import cost per milligram formulary EMA Solved On the subject in the title: EU-wide position versus national implementation Working notes rather than a conclusion. A methods question rather than a substantive one, about eu-wide position versus national…		2	54k	19mo
About the Red flags category Sourcing › Red flags mislabelling underdosing documentation quality Pinned Wiki Closed Patterns that reliably precede a problem. Documented, dated, and free of accusation without evidence. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	57k	17mo
Athletes in weight-category sports: a different risk calculus Clinical › Special populations older adults adolescents disordered eating chronic kidney disease Solved Athletes in weight-category sports: a different risk calculus — setting out what I have, and where I think it stops being reliable. Something about athletes in weight-category sports does not reconcile and I…	+38	42	6.6k	1d
Signs of dehydration worth acting on Safety › Adverse events gallbladder delayed gastric emptying pancreatitis vomiting Solved Signs of dehydration worth acting on — setting out what I have, and where I think it stops being reliable. Signs of dehydration worth acting, from the point of view of someone who has read the documentation…	+34	38	5.9k	21mo
Splitting an overlong document into two Documentation › Wiki requests promoted to docs review date wiki post Posting this under the heading it deserves: Splitting an overlong document into two Everything below is what sits behind that. Trying to work out what would count as evidence on splitting an overlong…	+30	34	6.2k	1d
Revisiting: Sample size in a voluntary survey: the selection problem Data & Tools › Datasets data table confounding site feedback observational data Solved Revisiting: Sample size in a voluntary survey: the selection problem — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin Sample size down and I want to…		2	56k	9mo
Import rules for personal quantities, by jurisdiction, dated Sourcing › Regulatory compounding MHRA FDA personal import On the subject in the title: Import rules for personal quantities, by jurisdiction, dated Working notes rather than a conclusion. I was wrong about import rules for personal quantities in a thread last spring…		3	60k	12mo
What would change my mind about repair peptides: a specific answer — one year on Compounds › Repair & healing peptides needs a source observational data TB-500 preprint Closed What would change my mind about repair peptides: a specific answer — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. Documentation question rather than a…	+9	13	42k	19mo
Persistent vomiting and the threshold for seeking help — one year on Safety › Adverse events hypoglycaemia vomiting gallbladder delayed gastric emptying Persistent vomiting and the threshold for seeking help — one year on Writing it up because I had to work it out twice and would rather nobody else did. I would like to disagree carefully with the settled view…	+39	43	596	19mo
Cross-border purchase within the EU: the actual rules Access › International MHRA EMA telehealth NHS Solved Cross-border purchase within the EU: the actual rules Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers on cross-border…	+6	10	41k	11mo
Canadian access and provincial variation — one year on Regional › North America FDA compounding insurance Canadian access and provincial variation — one year on Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Canadian access and provincial variation…	+43	47	964	12mo
Reused chromatograms across lots: how to spot it — what changed since Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards documentation quality Solved Reused chromatograms across lots: how to spot it — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Reused chromatograms across…	+34	39	20k	2mo
About the Datasets category Data & Tools › Datasets data table observational data confounding Pinned Wiki Community-collected datasets, their collection methods, and their limitations. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a…	+6	11	42k	12mo
[2026 update] What a good consultation looks like from the other side Clinical › Prescriber conversations beginner friendly type 2 diabetes telehealth The question in the title: What a good consultation looks like from the other side I will give what I have already checked below so nobody repeats it. Good consultation: what I expected, what I found, and the…	+32	36	13k	1mo
DXA precision and the least significant change for lean mass — what changed since Outcomes › Body composition DXA data table lean mass loss bioimpedance Solved DXA precision and the least significant change for lean mass — what changed since — setting out what I have, and where I think it stops being reliable. A question about measurement precision rather than about…		2	56k	11mo
[2026 update] Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide tirzepatide effect size randomised trial Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Tirzepatide in…		2	58k	11mo
Revisiting: Reading order for a first week here, and what to skip until later Start Here › Welcome guidelines trust levels onboarding Posting this under the heading it deserves: Revisiting: Reading order for a first week here, and what to skip until later Everything below is what sits behind that. Trying to work out what would count as…		2	60k	4mo
Journal club: how we handle discontinuation in obesity trials — what changed since Evidence › Journal club number needed to treat estimand risk of bias randomised trial Solved Journal club: how we handle discontinuation in obesity trials — what changed since — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it…	+14	18	35k	8mo
Revisiting: The arithmetic of an intermediate dose between two label steps Practice › Dosing & titration titration worked example dose reduction tirzepatide Revisiting: The arithmetic of an intermediate dose between two label steps Writing it up because I had to work it out twice and would rather nobody else did. I have read the maintained page on this and I…	+41	45	808	2mo
Revisiting: Mobile reading experience on long topics Meta › Site feedback moderation guidelines site feedback Solved Posting this under the heading it deserves: Revisiting: Mobile reading experience on long topics Everything below is what sits behind that. Bringing the figures rather than the impression, since a process…	+10	15	34k	10h
When a dose reduction is the correct response to a side effect Practice › Dosing & titration dose reduction tirzepatide titration missed dose Solved When a dose reduction is the correct response to a side effect — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the maintained page on this and I still have…	+38	42	2.7k	19h
Contributing data without breaching anyone's privacy — what changed since Data & Tools › Datasets observational data confounding site feedback data table On the subject in the title: Contributing data without breaching anyone's privacy — what changed since Working notes rather than a conclusion. What changes if the standard account of Contributing data without…		2	58k	17mo