Ranked by engagement

Top topics — all time page 28

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

This week This month This quarter This year All time

1,535 topics · page 28 of 40

Topic	Participants	Replies	Views	Activity
Coming back to: Oxidation and deamidation mass shifts, tabulated Analytics › Mass spectrometry LC-MS charge states MALDI-TOF high-resolution MS Oxidation and deamidation mass shifts, tabulated — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Oxidation and deamidation mass…	+34	38	4.8k	10mo
About the Site feedback category Meta › Site feedback site feedback moderation guidelines Pinned Wiki Closed Bugs, friction, and the parts of the site that do not work the way you expected. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and…		4	54k	10mo
Second pass at: Transit times by route, from a logged dataset Sourcing › Logistics customs temperature excursion cold chain shipping On the subject in the title: Second pass at: Transit times by route, from a logged dataset Working notes rather than a conclusion. Posting a small dataset on Transit times. It is mine, it is uncontrolled, and…		2	59k	19mo
Request: export my own posts Meta › Feature requests translation site feedback wiki post Posting this under the heading it deserves: Request: export my own posts Everything below is what sits behind that. I have spent a fortnight trying to pin export down and I want to set out where I have got…		2	57k	6mo
Cold solution and stinging: the simplest fix Practice › Administration injection site rotation subcutaneous injection missed dose Posting this under the heading it deserves: Cold solution and stinging: the simplest fix Everything below is what sits behind that. An honest uncertainty about cold solution and stinging rather than a…	+35	39	8.2k	30d
Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of clearance pathways is wrong? I…	+11	15	43k	2mo
What "verified" means on our vendor pages, stated narrowly Sourcing › Vendor reports batch & lot numbers disputed documentation quality third-party testing What "verified" means on our vendor pages, stated narrowly — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how a record should be read rather than…	+27	31	27k	7mo
PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Compounds › Oral incretins PIONEER programme SOUL trial randomised trial orforglipron Solved PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one — setting out what I have, and where I think it stops being reliable. Posting a small dataset on PIONEER 6 cardiovascular…	+25	29	22k	1d
Fixed versus detachable needles: the trade-offs — does this still hold? Devices › Syringes & needles syringe units needle gauge & length dead volume subcutaneous injection Solved Fixed versus detachable needles: the trade-offs — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Working notes on Fixed versus detachable…	+8	12	39k	15h
Transit times by route, from a logged dataset Sourcing › Logistics packaging customs shipping Solved Transit times by route, from a logged dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on transit times. It is mine, it is uncontrolled, and…	+34	38	3.6k	18h
Oral semaglutide bioavailability and its variability between people Compounds › Oral incretins SOUL trial oral semaglutide randomised trial Posting this under the heading it deserves: Oral semaglutide bioavailability and its variability between people Everything below is what sits behind that. I would like to know what people here actually do…	+44	48	574	3mo
Why I ask for the gradient before I discuss the number Analytics › HPLC & UHPLC gradient method data table HPLC system suitability The question in the title: Why I ask for the gradient before I discuss the number I will give what I have already checked below so nobody repeats it. I would like to understand what this number means before I…	+35	39	4.9k	20mo
Coming back to: What the published dose-response for semaglutide actually looks like above 2.4 mg Compounds › Semaglutide effect size type 2 diabetes semaglutide STEP programme Solved The question in the title: What the published dose-response for semaglutide actually looks like above 2.4 mg I will give what I have already checked below so nobody repeats it. I would like to know what…	+23	27	9.9k	1mo
Coming back to: Telehealth prescribing models in the US Regional › North America telehealth FDA compounding insurance Posting this under the heading it deserves: Telehealth prescribing models in the US Everything below is what sits behind that. Telehealth prescribing models — I have the observation and I do not trust my…	+26	30	17k	17h
Vagal afferents and the gut-brain pathway Pharmacology › Receptor biology semaglutide tirzepatide retatrutide long read On the subject in the title: Vagal afferents and the gut-brain pathway Working notes rather than a conclusion. Vagal afferents — I have the observation and I do not trust my interpretation of it, so I am…	+5	9	44k	13mo
Journal club: SELECT, absolute risk, and how it was reported Evidence › Journal club journal club estimand randomised trial effect size Journal club: SELECT, absolute risk, and how it was reported Writing it up because I had to work it out twice and would rather nobody else did. A question about what the numbers mean rather than what they…		2	52k	1mo
Labelling requirements for research chemicals Sourcing › Regulatory research use only MHRA FDA Under review Labelling requirements for research chemicals — setting out what I have, and where I think it stops being reliable. The question about labelling requirements for research chemicals that I actually want…	+5	9	45k	4mo
Severe gastroparesis and why this class is a poor fit — one year on Safety › Contraindications disordered eating delayed gastric emptying thyroid C-cell question pancreatitis Closed Severe gastroparesis and why this class is a poor fit — one year on — setting out what I have, and where I think it stops being reliable. Asking about Severe gastroparesis directly, because I have read four…	+19	23	23k	7mo
Turnaround times and what they mean for a decision — one year on Sourcing › Independent verification Medutest PeptideMeter VendorInvestigate third-party testing On the subject in the title: Turnaround times and what they mean for a decision — one year on Working notes rather than a conclusion. Reading back through what has been written here about Turnaround times,…	+25	29	22k	18mo
A parcel stationary at a customs facility for nine days — does this still hold? Sourcing › Logistics temperature excursion packaging cold chain customs Solved The question in the title: A parcel stationary at a customs facility for nine days — does this still hold? I will give what I have already checked below so nobody repeats it. A logistics question, since the…	+23	27	12k	1mo
Tirzepatide's shorter half-life and its one practical consequence Compounds › Tirzepatide SURPASS programme randomised trial effect size tirzepatide Wiki On the subject in the title: Tirzepatide's shorter half-life and its one practical consequence Working notes rather than a conclusion. Documentation question rather than a pharmacological one, but about this…	+18	29	20k	8mo
Isotonicity and what happens when you get it wrong Pharmacology › Formulation chemistry sterile water counter-ion content storage On the subject in the title: Isotonicity and what happens when you get it wrong Working notes rather than a conclusion. I was wrong about isotonicity in a thread last spring and I would like to correct it…	+27	31	11k	18mo
Column chemistry choices for a 40-residue peptide Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Column chemistry choices for a 40-residue peptide — setting out what I have, and where I think it stops being reliable. Collecting what is known about column chemistry choices in one place, because it is…	+39	43	1.1k	10mo
About the Regulatory category Sourcing › Regulatory research use only compounding FDA Pinned Wiki Research-use-only status, compounding rules, import restrictions, and the primary documents behind them. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is…		4	49k	4mo
Coming back to: Reading a supplier's product description as a marketing document Compounds › Other compounds needs a source custom synthesis research use only mislabelling Reading a supplier's product description as a marketing document Writing it up because I had to work it out twice and would rather nobody else did. Documentation question rather than a pharmacological one,…	+35	39	688	5mo
Follow-up: Oral contraceptives and delayed emptying: what the data shows Practice › Interactions hypoglycaemia delayed gastric emptying needs a source Closed Oral contraceptives and delayed emptying: what the data shows — setting out what I have, and where I think it stops being reliable. A follow-up question about Oral contraceptives and delayed emptying that I…	+31	35	13k	18mo
Selection into a registry and what it does to the estimate Evidence › Study critique risk of bias disputed observational data Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Working notes on selection rather than a conclusion. I would rather post the…		2	55k	7mo
Reimbursement variation across member states Regional › European Union EMA personal import cost per milligram Reimbursement variation across member states Writing it up because I had to work it out twice and would rather nobody else did. Asking about reimbursement variation across member states directly, because I…	+7	11	39k	3mo
Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics semaglutide liraglutide worked example tirzepatide Albumin binding and how it produces a long half-life — setting out what I have, and where I think it stops being reliable. A narrow question about albumin binding, deliberately narrow, because the broad…	+38	44	6.6k	14mo
GLP-1 receptor distribution: central and peripheral — one year on Pharmacology › Receptor biology long read retatrutide amylin analogues semaglutide GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1 receptor distribution rather than a…	+7	11	43k	3mo