Ranked by engagement

Top topics — all time page 34

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 34 of 40

Topic	Participants	Replies	Views	Activity
Relative retention time as a better inter-laboratory comparator Analytics › Method validation linearity recovery precision & repeatability stability-indicating method On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. What changes if the standard account of relative retention time is wrong? I…	+7	11	28k	14mo
Revisiting: Taste changes and food aversion, reported and discussed Practice › Side effects nausea vomiting constipation Revisiting: Taste changes and food aversion, reported and discussed Writing it up because I had to work it out twice and would rather nobody else did. Two things I would like separated before anyone answers…	+20	25	4.3k	1d
Why chargeback is not the safety net people assume Sourcing › Payments research use only payments documentation quality Solved Asking directly, because I could not find a straight answer: Why chargeback is not the safety net people assume Asking about the record rather than the transfer. Every order leaves a trail: an order…	+22	26	2.5k	2d
Relative retention time as a better inter-laboratory comparator — does this still hold? Analytics › Method validation LOD & LOQ precision & repeatability stability-indicating method recovery Solved Wiki Relative retention time as a better inter-laboratory comparator — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard…	+11	15	21k	21mo
Coming back to: Amylin analogue mechanism: satiety signalling separate from GLP-1 Compounds › Cagrilintide & amylin analogues cagrisema effect size randomised trial cagrilintide On the subject in the title: Amylin analogue mechanism: satiety signalling separate from GLP-1 Working notes rather than a conclusion. Trying to work out what would count as evidence on Amylin analogue…	+27	31	671	12mo
When to stop reading forums, including this one — the long version Wellbeing › Mental health disordered eating beginner friendly mood Solved Asking directly, because I could not find a straight answer: When to stop reading forums, including this one — the long version Something that has come up for me and that I suspect is more common than the…	+23	27	8.3k	14mo
Why a pen's dose steps are fixed and what that costs you — one year on Devices › Pens & autoinjectors storage subcutaneous injection missed dose Solved Closed Asking directly, because I could not find a straight answer: Why a pen's dose steps are fixed and what that costs you — one year on Question about a metering device rather than about a syringe, because the…	+30	34	2.9k	11mo
A pooled estimate that changed when one trial was added Evidence › Meta-analyses meta-analysis publication bias effect size Solved A pooled estimate that changed when one trial was added — setting out what I have, and where I think it stops being reliable. I was wrong about pooled estimate in a thread last spring and I would like to…	+24	28	3.5k	2d
How to tell whether your question is already answered on a maintained page Start Here › Welcome guidelines onboarding trust levels Solved How to tell whether your question is already answered on a maintained page — that is the question, and I have not found it answered plainly anywhere I have looked. Question in the title. Context below, and I…	+5	9	30k	3mo
Payment mechanics and the recovery options that do not exist — what changed since Sourcing › Payments documentation quality payments research use only Solved On the subject in the title: Payment mechanics and the recovery options that do not exist — what changed since Working notes rather than a conclusion. A payments question, with the mechanics separated from…	+14	18	17k	13mo
Feature request: should a dose-equivalence tool exist at all? Data & Tools › Calculators site feedback worked example concentration maths syringe units Closed Feature request: should a dose-equivalence tool exist at all? — that is the question, and I have not found it answered plainly anywhere I have looked. Reading back through what has been written here about…	+21	25	4.8k	18mo
System suitability injections: if they failed, the run did not happen Analytics › HPLC & UHPLC peak integration HPLC data table gradient method Posting this under the heading it deserves: System suitability injections: if they failed, the run did not happen Everything below is what sits behind that. Proposing that system suitability injections…	+23	27	6k	11mo
Second opinions: how to seek one without burning the first Clinical › Prescriber conversations telehealth prior authorisation beginner friendly type 2 diabetes Closed Second opinions: how to seek one without burning the first Writing it up because I had to work it out twice and would rather nobody else did. The question about second opinions that I actually want answered…	+1	5	33k	19mo
Why catalogue breadth is not evidence of anything Compounds › Other compounds research use only needs a source custom synthesis Under review Why catalogue breadth is not evidence of anything I have a specific reason for asking rather than idle curiosity, and the context is below. What changes if the standard account of catalogue breadth is wrong?…		2	38k	2d
Second pass at: Cost versus information: making the trade-off explicitly Analytics › Home & field testing third-party testing documentation quality ELISA Posting this under the heading it deserves: Second pass at: Cost versus information: making the trade-off explicitly Everything below is what sits behind that. Posting a small dataset on Cost versus…	+23	27	6.1k	22h
Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? Compounds › Semaglutide type 2 diabetes randomised trial semaglutide SELECT trial Solved Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in the first…	+5	9	30k	8d
What happens after your first post: likes, trust levels, and why none of it matters much Start Here › Welcome guidelines beginner friendly trust levels onboarding Solved Asking directly, because I could not find a straight answer: What happens after your first post: likes, trust levels, and why none of it matters much I want to check my reasoning rather than get a conclusion.…	+15	19	17k	16mo
Why our vendor pages link the storefront and mark it sponsored Sourcing › Vendor reports batch & lot numbers Janoshik Analytical certificate of analysis disputed Solved Why our vendor pages link the storefront and mark it sponsored — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about vendor pages link the storefront directly,…	+17	21	335	18mo
Follow-up: Retatrutide phase 2 in type 2 diabetes: the Lancet paper Compounds › Retatrutide retatrutide effect size TRIUMPH programme preprint Retatrutide phase 2 in type 2 diabetes: the Lancet paper Writing it up because I had to work it out twice and would rather nobody else did. A follow-up question about Retatrutide phase 2 in type that I did…	+1	5	31k	8mo
Selection into a registry and what it does to the estimate — a second dataset Evidence › Study critique confounding risk of bias effect size disputed Solved Posting this under the heading it deserves: Selection into a registry and what it does to the estimate — a second dataset Everything below is what sits behind that. Posting a small dataset on Selection. It is…	+28	32	1.3k	1d
Why we ask for units every single time, with three examples of what goes wrong — what changed since Start Here › How to Ask onboarding guidelines worked example beginner friendly The question in the title: Why we ask for units every single time, with three examples of what goes wrong — what changed since I will give what I have already checked below so nobody repeats it. Counting it…	+14	18	19k	2mo
Coming back to: Why semaglutide solutions can look faintly opalescent and when that matters Compounds › Semaglutide SELECT trial randomised trial STEP programme Asking directly, because I could not find a straight answer: Why semaglutide solutions can look faintly opalescent and when that matters Reading back through what has been written here about semaglutide…	+16	20	17k	13mo
Follow-up: Why we hide unevidenced fraud accusations and log the hiding Sourcing › Red flags mislabelling disputed moderation underdosing The question in the title: Why we hide unevidenced fraud accusations and log the hiding I will give what I have already checked below so nobody repeats it. Filing a documentation observation rather than a…	+12	16	17k	12mo
Why oral semaglutide needs an absorption enhancer at all — one year on Compounds › Oral incretins randomised trial SOUL trial oral semaglutide PIONEER programme Why oral semaglutide needs an absorption enhancer at all — one year on — that is the question, and I have not found it answered plainly anywhere I have looked. Reading back through what has been written here…	+11	15	17k	24d
Preprint servers and what screening they do — the long version Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. A preprint question rather than a question about the finding in it. The…	+7	11	26k	4mo
Patterns that reliably precede a problem, documented Sourcing › Red flags documentation quality disputed mislabelling underdosing Patterns that reliably precede a problem, documented — setting out what I have, and where I think it stops being reliable. Patterns, from the point of view of someone who has read the documentation and is…	+3	7	31k	16mo
Pen wastage and its effect on real cost — the long version Access › Pricing formulary data table cost per milligram compounding Posting this under the heading it deserves: Pen wastage and its effect on real cost — the long version Everything below is what sits behind that. A narrow question about Pen wastage, deliberately narrow,…		2	34k	13mo
Sleep quality changes during weight loss Wellbeing › Sleep heart rate obstructive sleep apnoea fatigue On the subject in the title: Sleep quality changes during weight loss Working notes rather than a conclusion. Asking about sleep quality changes during weight on behalf of the question I keep seeing asked…	+27	31	555	5h
Gradient steepness and apparent purity: a worked comparison — the long version Analytics › HPLC & UHPLC HPLC system suitability gradient method Gradient steepness and apparent purity: a worked comparison — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Gradient steepness and apparent…		2	32k	1d
Shoulders, tangent skims, and defensible integration Analytics › HPLC & UHPLC peak integration UV & DAD detection HPLC gradient method Posting this under the heading it deserves: Shoulders, tangent skims, and defensible integration Everything below is what sits behind that. Setting out an integration problem with the actual figures, because…	+16	20	11k	13h