p.novotny

TL2 Regular · Prague, CZ

Lifter. Interested in preserving what I spent a decade building while losing fat.

Joined 3 June 2025 · last posted 4d

102 posts, newest first. Showing up to 150.

[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #106 · Access › International · 24 Jul 2026 · 4 likes Travelling with a prescribed medicine is a documentation question and the requirements are published by the destination rather than the origin.
Restarting after a long gap: what the labelling implies Replied, post #37 · Practice › Dosing & titration · 21 Jul 2026 · 3 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
Follow-up: How compounding permissions changed when supply normalised Replied, post #24 · Sourcing › Regulatory · 15 Jul 2026 · 0 likes That is the distinction I keep failing to hold on to. Written down now.
Follow-up: Signs of dehydration worth acting on Replied, post #25 · Safety › Adverse events · 15 Jul 2026 · 0 likes Severe gastrointestinal events: persistent vomiting, abdominal pain out of proportion, or signs of bowel obstruction warrant urgent evaluation. Mild nausea and…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #60 · Practice › Dosing & titration · 13 Jul 2026 · 8 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose. I…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #57 · Compounds › Retatrutide · 12 Jul 2026 · 2 likes On post #56 — agreed on the reasoning, with one qualification. Triple agonism: is the effect additive, synergistic, or neither? A phase 2 comparison of tirzepatide…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #52 · Analytics › Impurities & related substances · 6 Jul 2026 · 13 likes Following, with nothing to contribute beyond having asked the same thing elsewhere.
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #111 · Evidence › Journal club · 5 Jul 2026 · 20 likes Worth separating two things that post #109 runs together. A definition problem is doing most of the work in this orforglipron phase 2 discussion. Once the term is…
Submitting a sample: the process end to end Replied, post #58 · Sourcing › Independent verification · 4 Jul 2026 · 29 likes Post #55 answers the question as asked. The question underneath it is different. It does not extend to lots nobody has seen, it is not a recommendation, and it says…
NHS criteria and how they are applied in practice Replied, post #8 · Regional › UK & Ireland · 21 Jun 2026 · 2 likes Picking up post #7: that is the part I would want checked first. Members outside these two jurisdictions reading this thread should note that none of it transfers,…
Racemisation and why it is invisible to a mass measurement Replied, post #123 · Analytics › Impurities & related substances · 15 Jun 2026 · 0 likes Deletion sequences (incomplete coupling during synthesis): lower in mass by one residue. Chromatographically they usually elute earlier or later depending on the…
Fixed versus detachable needles: the trade-offs — does this still hold? Replied, post #7 · Devices › Syringes & needles · 13 Jun 2026 · 0 likes Second this, and I would have said it less carefully.
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #105 · Practice › Storage & stability · 9 Jun 2026 · 22 likes A definition problem is doing most of the work in this reconstituted discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is…
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just… Replied, post #123 · Compounds › Tirzepatide · 3 Jun 2026 · 1 like Taking post #122 at face value and following it one step further. SURMOUNT-1 reported weight reduction of a magnitude that was the largest for a pharmacological…
Electrolyte supplements: which ones do anything Replied, post #22 · Nutrition & Training › Hydration & electrolytes · 3 Jun 2026 · 0 likes Electrolyte supplements came up in a thread eighteen months ago and was answered well. I cannot find it, which is itself the problem, so here is the reconstruction.
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #52 · Practice › Storage & stability · 1 Jun 2026 · 10 likes Reconstituted material carried in a bag for a day is a temperature excursion even in a cool climate. Where that matters is cumulative exposure over weeks rather than a…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #19 · Compounds › Oral incretins · 29 May 2026 · 22 likes Adding the measurement that post #18 says would settle it. Research-use-only oral material is not a licensed tablet and there is no reason to assume it carries a…
Research-use-only status: what it means legally and practically Replied, post #42 · Compounds › Other compounds · 14 May 2026 · 2 likes Anything sold as a blend is two analytical problems and usually one number. A single purity figure for a two-component preparation does not tell you the ratio, and the…
Sample handling between despatch and injection Replied, post #55 · Analytics › Method validation · 20 Apr 2026 · 7 likes The distinction between a qualified instrument and a validated method is worth keeping. Both are needed and they fail in different ways. This is the sort of thing the…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #4 · marked as the solution · Analytics › Home & field testing · 18 Apr 2026 · 7 likes A note on how Lateral-flow and colorimetric approaches gets discussed rather than on Lateral-flow and colorimetric approaches itself: the confident posts get the…
The "under review" status pill and when a moderator applies it Replied, post #73 · Evidence › Preprints · 14 Apr 2026 · 2 likes Peer review catches some things reliably — missing methods, unsupported conclusions, statistical mistakes of the obvious kind — and misses others routinely. Knowing…
Journal club: SURMOUNT-4 and continuation versus withdrawal Replied, post #27 · Evidence › Journal club · 11 Apr 2026 · 5 likes Worth separating two things that post #23 runs together. Checked the SURMOUNT-4 and continuation versus withdrawal claim against the primary source this morning. It…
A site rotation scheme that is easy enough to actually follow Replied, post #38 · Practice › Administration · 11 Apr 2026 · 12 likes Confirming post #37 from a second method, which matters more than confirming it from a second person. Two people in this thread mean different things by site rotation…
Anaesthesia and elective surgery: the aspiration question Replied, post #75 · Practice › Interactions · 5 Apr 2026 · 26 likes Post #71 describes the usual case. This is about the unusual one. Anaesthesia and elective surgery would be much easier to settle if anyone reported the denominator.…
Insomnia at a dose step: reported experiences — the long version Replied, post #8 · Wellbeing › Sleep · 3 Apr 2026 · 16 likes A referral for a proper sleep study answers in one night what months of forum discussion cannot. The right answer here may simply be that it has not been measured.
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #115 · Clinical › Bloodwork · 30 Mar 2026 · 0 likes A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line. This is the version I would want a new member to read…
Personal import allowances, compared — a second dataset Replied, post #94 · Access › International · 29 Mar 2026 · 0 likes The most useful reply I ever got about Personal import allowances was a request to state my units. It sounds like pedantry and it has saved me twice.
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #76 · Start Here › How to Ask · 21 Mar 2026 · 0 likes Units. Everything needs units. This is why we ask every single time. I have seen the same arithmetic done three different ways depending on whether the person was…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #53 · Research Methods › N-of-1 designs · 9 Mar 2026 · 12 likes Generalisability: a robust n-of-1 result applies to you. It does not tell you much about whether the effect generalises to others similar to you, much less to people…
Reading an interaction checker output critically Replied, post #131 · Practice › Interactions · 26 Feb 2026 · 2 likes A supplement is a drug for interaction purposes, and the fact that it is sold without a prescription tells you nothing about whether it interacts. The paperwork is…
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #129 · Compounds › Semaglutide · 26 Feb 2026 · 25 likes That is clearer than the version I had in my head. Thank you.
Whether protein timing matters at a large deficit Replied, post #27 · Nutrition & Training › Protein & intake · 20 Feb 2026 · 22 likes Distribution across the day appears to matter less than total for most outcomes, and it matters practically because a single large meal is harder when appetite is…
Revisiting: Maintainer handover: how it works Replied, post #7 · Meta › Wiki maintenance · 20 Feb 2026 · 5 likes Post #5 put the caveat in the right place and I want to underline it. An observation about Maintainer handover that I cannot explain and am posting anyway, on the…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #8 · Practice › Dosing & titration · 14 Feb 2026 · 27 likes Writing down the date, the dose and the site each week takes fifteen seconds and is the single most useful record anyone here keeps. Memory reconstructs a titration…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #39 · Clinical › Special populations · 11 Feb 2026 · 0 likes Same experience here, different supplier, so it is at least not unique to one of them.
Seven-day rolling means and why weekly readings mislead — one year on Replied, post #15 · Outcomes › Progress reports · 7 Feb 2026 · 29 likes A seven-day rolling mean of daily readings has a much smaller standard error and makes most apparent plateaus and sudden drops disappear. Written in the hope of being…
Preprint servers and what screening they do Replied, post #27 · Evidence › Preprints · 17 Jan 2026 · 2 likes Everything in post #23 holds. The case it does not cover is the one I have. Version numbers on a preprint server matter. Citing version one of something now on version…
Muscle cramps: the ordinary causes before the exotic ones Replied, post #36 · Practice › Side effects · 16 Jan 2026 · 0 likes Two questions I would want answered before drawing anything from the muscle cramps data above: how were the cases selected, and what happened to the ones that dropped…
Distinguishing expected GI effects from something that needs urgent attention Replied, post #20 · Practice › Side effects · 3 Jan 2026 · 16 likes Post #16 describes the usual case. This is about the unusual one. Effects that improve with time and effects that improve with dose reduction are different findings.…
Pre-registering a personal experiment, seriously — a second dataset Replied, post #15 · Research Methods › N-of-1 designs · 28 Dec 2025 · 10 likes Post #13 and I disagree about the size of the effect, not about the direction. The interesting personal experiments are the ones where the answer was no. They are also…
Vomiting: when it is expected and when it is a reason to stop Replied, post #57 · Practice › Side effects · 28 Dec 2025 · 11 likes Coming back to post #53, because the follow-up matters more than the original answer. The published rates come from populations that were titrated on a defined schedule…
Why "add 2 mL" is not an instruction Replied, post #22 · Practice › Reconstitution · 27 Dec 2025 · 0 likes Preservative effectiveness is tested against a defined microbial challenge under defined conditions. It is not a licence to treat an entered vial as sterile…
Reconciling a label claim with a content assay Replied, post #5 · Analytics › COA interpretation · 26 Dec 2025 · 1 like Peptide content and chromatographic purity are separate determinations and a certificate that reports only one has answered only one question. Content is the one that…
Publishing an inconvenient result: a case study — the long version Replied, post #48 · Sourcing › Independent verification · 24 Nov 2025 · 24 likes Picking up post #46: that is the part I would want checked first. My understanding of Publishing an inconvenient result is a few years old and may have been superseded.…
Interpreting a result that disagrees with the supplier's certificate Replied, post #18 · Sourcing › Independent verification · 20 Nov 2025 · 0 likes Where I part company with post #16, and it is a narrow parting. Combining a chromatographic result with a documentation review gives a more complete picture than two…
The anatomy of a question that gets answered within an hour — the long version Replied, post #90 · Start Here › How to Ask · 13 Nov 2025 · 33 likes If your question has a deadline — a parcel in transit, a delivery you have to accept or refuse — say so. People answer differently when there is a clock on it. Somebody…
What a purity-only report leaves out Replied, post #81 · Sourcing › Independent verification · 10 Nov 2025 · 0 likes The arithmetic in post #80 is right; the assumption feeding it is the part to check. The record shows what was measured. Everything beyond that is inference and this…
How to read a forest plot, properly, from scratch Replied, post #51 · Evidence › Trials · 6 Nov 2025 · 12 likes Absolute and relative effects answer different questions. Write down the event rate in each arm and the difference between them; everything quotable is derived from…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #11 · Pharmacology › Pharmacokinetics · 30 Oct 2025 · 5 likes Metabolism for peptide drugs is proteolytic rather than hepatic in the usual sense, which is why the cytochrome interaction questions that dominate small-molecule…
Where to report an adverse event officially, by region — a second dataset Replied, post #66 · Safety › Adverse events · 28 Oct 2025 · 11 likes Where to report: in many countries there is a pharmacovigilance system where adverse events can be reported. FDA MedWatch in the US, Yellow Card in UK, EudraVigilance…
What a purity-only report leaves out Replied, post #62 · Sourcing › Independent verification · 27 Oct 2025 · 4 likes Coming back to post #60, because the follow-up matters more than the original answer. An honest declaration on purity-only: I have a prior here and it is strong enough…
Why oral semaglutide needs an absorption enhancer at all Replied, post #42 · Compounds › Oral incretins · 17 Oct 2025 · 28 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
High-resolution MS on aggregates and what it can see Replied, post #90 · Analytics › Mass spectrometry · 11 Oct 2025 · 28 likes I would call the community position on high-resolution likely rather than established, and I would be comfortable defending that hedge.
An orphaned page with no inbound links — the long version Replied, post #11 · Meta › Wiki maintenance · 10 Oct 2025 · 16 likes On post #9 — agreed on the reasoning, with one qualification. Review dates: each maintained page has a review date (the date by which it should be checked). If a page…
Coming back to: Resolution and tailing factor: real acceptance criteria Replied, post #99 · Analytics › HPLC & UHPLC · 8 Oct 2025 · 0 likes If two laboratories disagree by more than two or three percentage points, work through method, integration, sample handling, whether it was the same lot and the same…
Hypertension improvement and when medication needs revisiting Replied, post #65 · Clinical › Comorbidities · 17 Sep 2025 · 1 like Reading this hypertension improvement thread as someone who came in with a fixed view: the third and seventh replies moved me and the confident ones did not.
Payment method and the leverage it gives you, ranked Replied, post #18 · Sourcing › Payments · 16 Sep 2025 · 6 likes Adding the measurement that post #17 says would settle it. Where a supplier issues a quote with an expiry, honouring it after the expiry is a courtesy rather than an…
Documentation that appears only after payment Replied, post #22 · Sourcing › Red flags · 10 Sep 2025 · 19 likes Building on post #21 rather than restating it. Documentation has been discussed here with more heat than it deserves, mostly because two definitions have been in play…
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #23 · Analytics › Method validation · 30 Aug 2025 · 19 likes Narrowing post #22, because the general version has more than one answer. I changed my mind about LOD and LOQ after someone here asked me for the source and I could not…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #40 · Analytics › HPLC & UHPLC · 30 Aug 2025 · 0 likes Peaks that do not elute do not appear in the area percentage. Aggregates and strongly retained species can be entirely invisible to a standard method, which is a…
A parcel that arrived warm: a decision process, not a verdict Replied, post #17 · Practice › Storage & stability · 29 Aug 2025 · 22 likes Useful. I had the fact and not the reason, which turns out to be the important half.
Thyroid function tests during substantial weight change Replied, post #44 · Clinical › Bloodwork · 28 Aug 2025 · 1 like Ask what decision the result would change before ordering it. A test whose result changes nothing is a test that generates worry rather than information. Genuinely open…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #60 · Compounds › Oral incretins · 7 Jul 2025 · 26 likes Missed doses behave differently for a daily oral than for a weekly injection. With a short interval you are near a trough rather than perturbing a slowly moving…
Coming back to: Official shortage notices and what they authorise Replied, post #45 · Access › Shortages · 1 Jul 2025 · 9 likes I had written a reply contradicting post #43 and deleted it. Here is what survived. The most useful contribution is a link to the current official notice rather than an…
Repeatability versus intermediate precision Replied, post #41 · Analytics › Method validation · 22 Jun 2025 · 1 like What I would tell a new member reading about repeatability versus intermediate precision for the first time: the confident posts are not the reliable ones, and the…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #139 · Practice › Reconstitution · 19 Jun 2025 · 0 likes Reading rather than answering, but this is the post I would point somebody at.
Journal club: SURMOUNT-1, read without the press release Replied, post #139 · Evidence › Journal club · 17 Jun 2025 · 7 likes SURMOUNT-1: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know…
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #30 · Compounds › Repair & healing peptides · 3 Jun 2025 · 12 likes Post #29 is right about the mechanism and I think understates the practical bit. Speaking only to TB-500 and thymosin beta-4 as I have actually seen it, rather than as…
Validating a calculator against hand arithmetic — what changed since Replied, post #94 · Data & Tools › Calculators · 27 May 2025 · 0 likes Significant figures in the output should not exceed what the inputs support. A concentration calculated from a nominal vial mass is not known to four decimal places.
Second pass at: Designing a personal experiment that could change your mind Replied, post #24 · Research Methods › N-of-1 designs · 19 May 2025 · 30 likes Measure the same thing the same way at the same time of day. Most of the noise in personal data is measurement protocol rather than biology. The number is defensible.…
Validating a calculator against hand arithmetic — what changed since Replied, post #77 · Data & Tools › Calculators · 19 May 2025 · 0 likes I will take the caveat as seriously as the claim, which is the point of putting it there.
Coverage for the indication versus for the drug Replied, post #61 · Access › Insurance & coverage · 11 May 2025 · 5 likes I had written a reply contradicting post #59 and deleted it. Here is what survived. The confident answers on coverage and the well-sourced answers are not the same…
DXA precision and the least significant change for lean mass — the long version Replied, post #23 · Outcomes › Body composition · 10 May 2025 · 25 likes Picking up post #20: that is the part I would want checked first. Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume,…
Titles that describe the question, not the situation Replied, post #8 · Start Here › How to Ask · 9 May 2025 · 1 like My experience of titles contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #43 · Sourcing › Independent verification · 3 May 2025 · 1 like Practical experience of Janoshik, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.
Publishing an inconvenient result: a case study Replied, post #14 · Sourcing › Independent verification · 30 Apr 2025 · 0 likes Blind sampling: submitting without the laboratory or seller knowing the source removes the two easiest ways for a result to be shaped: selective submission and…
Why plausible mechanism is not evidence of effect — one year on Replied, post #2 · Compounds › Repair & healing peptides · 27 Apr 2025 · 6 likes Publication patterns in the BPC-157 literature: a large proportion of the evidence comes from one research group. That is not necessarily wrong — one group can do…
Metformin co-administration and additive GI effects Replied, post #12 · Practice › Interactions · 24 Apr 2025 · 5 likes No disagreement from me. Posting only so the question does not look ignored.
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #44 · Evidence › Journal club · 19 Apr 2025 · 21 likes Adding a reference point for STEP 1. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately.
Follow-up: Documentation that appears only after payment Replied, post #5 · Sourcing › Red flags · 17 Apr 2025 · 1 like Confirming post #4 from a second method, which matters more than confirming it from a second person. Exaggerated claims without documentation: every compound has…
Fibre intake when total intake falls, and the constipation link Replied, post #48 · Nutrition & Training › Protein & intake · 2 Apr 2025 · 9 likes Following this. I have the same question and no better information than the first post.
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #127 · Compounds › Semaglutide · 13 Mar 2025 · 6 likes Everything in post #123 holds. The case it does not cover is the one I have. Gallbladder events appear in the labelling for this class and are more common with larger,…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #34 · Compounds › Tirzepatide · 7 Mar 2025 · 8 likes Answering the question post #32 raises rather than the one it answers. Half-life difference: tirzepatide is about 5 days versus semaglutide's week-long. Practically,…
Why we hide unevidenced fraud accusations and log the hiding Replied, post #47 · Sourcing › Red flags · 2 Feb 2025 · 19 likes Adding the measurement that post #44 says would settle it. Prices well below the rest of the market are a fact rather than a finding. They are worth noting and they do…
What we do not know about retatrutide, listed explicitly Replied, post #76 · Compounds › Retatrutide · 30 Jan 2025 · 0 likes Post #72 and I disagree about the size of the effect, not about the direction. Mass and identity: a report on retatrutide should state the mass detected by LC-MS, not…
Dose numbers for oral formulations are not comparable to injectable ones — a second… Replied, post #51 · Compounds › Oral incretins · 14 Jan 2025 · 0 likes Oral versus injectable exposure: comparing a 14 mg oral dose with a 0.5 mg injectable dose is comparing apples to a different fruit. The oral bioavailability is low…
Follow-up: Individual participant data versus aggregate data Replied, post #16 · Evidence › Meta-analyses · 8 Jan 2025 · 28 likes Study quality and weighting: some meta-analyses weight all studies equally; others weight by study size or study quality. The choice affects the result and should be…
Oxidation pathways for methionine and tryptophan Replied, post #6 · Analytics › Impurities & related substances · 25 Dec 2024 · 19 likes A supplier that can tell you what its principal impurity is has answered a harder question than one that can tell you its purity, and the answer is more useful.
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #82 · Compounds › Semaglutide · 24 Dec 2024 · 4 likes Post #79 describes the usual case. This is about the unusual one. What I would check first on Molecular mass of semaglutide is whether the thing being measured moved or…
Follow-up: Dead volume across syringe and needle combinations Replied, post #79 · Devices › Syringes & needles · 9 Dec 2024 · 2 likes Adding thanks rather than a view. I do not have a view worth the space.
Follow-up: Recovery when intake is low: what to cut first Replied, post #40 · Nutrition & Training › Resistance training · 23 Nov 2024 · 0 likes What would change my mind on Recovery is a second dataset collected by someone with no stake in the first. Until then I hold it loosely and I would rather say so than…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #46 · Clinical › Special populations · 23 Nov 2024 · 4 likes An update on my earlier Type 1 diabetes post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #38 · Evidence › Journal club · 21 Nov 2024 · 2 likes I had written a reply contradicting post #34 and deleted it. Here is what survived. Sessions on negative or null results are consistently the most instructive and the…
Isotope patterns and why the monoisotopic peak is not the tallest Replied, post #3 · Analytics › Mass spectrometry · 18 Nov 2024 · 0 likes On the opening post — agreed on the reasoning, with one qualification. The bit of isotope patterns that nobody enjoys is that the answer changes depending on what you…
Why "any advice?" is the least effective ending for a post Replied, post #41 · Start Here › How to Ask · 16 Nov 2024 · 0 likes If your question has a deadline — a parcel in transit, a delivery you have to accept or refuse — say so. People answer differently when there is a clock on it.
Revisiting: Moderation log format change Replied, post #26 · Meta › Announcements · 13 Nov 2024 · 7 likes This follows post #25 rather than contradicting it. Moderation log format change is one of those subjects where the general answer and the answer for a specific case…
Why "any advice?" is the least effective ending for a post Replied, post #7 · Start Here › How to Ask · 3 Nov 2024 · 0 likes Saving this. It is the version I will quote when the question comes round again.
Requesting a page: what makes a good request — what changed since Replied, post #129 · Documentation › Wiki requests · 13 Oct 2024 · 0 likes A request is more likely to succeed with a proposed outline attached. "Somebody should write about X" rarely moves; a structure and two sections does. The confident…
Second pass at: Food noise reducing and the disorientation that can follow Replied, post #29 · Wellbeing › Mental health · 13 Oct 2024 · 0 likes Post #27 put the caveat in the right place and I want to underline it. Where a member is finding this hard, the useful reply is usually a question rather than an…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #10 · Compounds › Cagrilintide & amylin analogues · 12 Oct 2024 · 3 likes Marking my uncertainty on amylin analogue mechanism explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it…
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #17 · Evidence › Journal club · 14 Aug 2024 · 0 likes The reason SURPASS-2 keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.
Journal club: FLOW and the renal composite, component by component Replied, post #69 · Evidence › Journal club · 15 Jul 2024 · 19 likes That is a fair summary of where the discussion has got to.