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Top topics — all time page 30

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 30 of 40

Topic	Participants	Replies	Views	Activity
A plateau that disappeared when I changed how I measured Outcomes › Progress reports DXA long read effect size Posting this under the heading it deserves: A plateau that disappeared when I changed how I measured Everything below is what sits behind that. I was wrong about plateau in a thread last spring and I would…	+27	31	7.2k	3mo
Whether protein timing matters at a large deficit Nutrition & Training › Protein & intake micronutrients lean mass loss fatigue Posting this under the heading it deserves: Whether protein timing matters at a large deficit Everything below is what sits behind that. A follow-up question about whether protein timing that I did not know…	+29	33	7.7k	4mo
Why one laboratory's 98.4% and another's 96.1% may not contradict Analytics › Method validation stability-indicating method LOD & LOQ linearity Solved Wiki Why one laboratory's 98.4% and another's 96.1% may not contradict I have a specific reason for asking rather than idle curiosity, and the context is below. Posting the method first, because I know what the…	+28	37	457	7mo
Sulfonylureas: the interaction most worth taking seriously Practice › Interactions needs a source metformin insulin Sulfonylureas: the interaction most worth taking seriously Writing it up because I had to work it out twice and would rather nobody else did. An honest uncertainty about sulfonylureas rather than a disguised…	+4	8	38k	6h
Forced degradation studies: designing one that is informative — does this still hold? Analytics › Method validation stability-indicating method precision & repeatability LOD & LOQ system suitability Solved The question in the title: Forced degradation studies: designing one that is informative — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Forced…	+37	41	1.2k	12mo
About the North America category Regional › North America FDA compounding insurance Pinned Wiki US and Canadian regulation, compounding, and coverage. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its author and a note. If the scope…	+3	7	43k	9mo
Severe abdominal pain: why this is not a forum question — one year on Safety › Adverse events pancreatitis delayed gastric emptying gallbladder vomiting Closed Severe abdominal pain: why this is not a forum question — one year on — setting out what I have, and where I think it stops being reliable. A narrow question about Severe abdominal pain, deliberately narrow,…		2	49k	10mo
Revisiting: Oral versus injected administration claims for BPC-157 Compounds › Repair & healing peptides observational data needs a source TB-500 BPC-157 Solved On the subject in the title: Revisiting: Oral versus injected administration claims for BPC-157 Working notes rather than a conclusion. A follow-up question about Oral versus injected administration claims…	+23	27	7.7k	15mo
Why quantitation is the hard part, not detection Analytics › Home & field testing LOD & LOQ third-party testing ELISA Why quantitation is the hard part, not detection I have a specific reason for asking rather than idle curiosity, and the context is below. Collecting what is known about quantitation in one place, because it…	+11	15	27k	12mo
IGF-1 as a surrogate endpoint and its limitations Compounds › Secretagogues & GH axis GHRP class needs a source observational data tesamorelin IGF-1 as a surrogate endpoint and its limitations Writing it up because I had to work it out twice and would rather nobody else did. IGF-1, and specifically the version of it that the documentation does not…	+5	9	35k	4mo
Two scans six weeks apart on different machines: a cautionary tale Outcomes › Body composition lean mass loss data table bioimpedance DXA Solved On the subject in the title: Two scans six weeks apart on different machines: a cautionary tale Working notes rather than a conclusion. A question about measurement precision rather than about physiology. Two…	+18	26	9.4k	2mo
Cost per milligram, computed honestly across formats Access › Pricing formulary cost per milligram data table Posting this under the heading it deserves: Cost per milligram, computed honestly across formats Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this…		2	47k	18mo
A revision dispute resolved on the topic rather than in the history Meta › Wiki maintenance wiki post maintainership moderation citation check A revision dispute resolved on the topic rather than in the history Writing it up because I had to work it out twice and would rather nobody else did. Proposing that revision dispute resolved deserves a…	+10	15	40k	16h
Dizziness on standing: the ordinary explanation first Nutrition & Training › Hydration & electrolytes blood pressure heart rate fatigue Posting this under the heading it deserves: Dizziness on standing: the ordinary explanation first Everything below is what sits behind that. A hydration and intake question, with the figures, since this one…	+22	26	27k	15mo
Follow-up: Evidence quality in the secretagogue literature: an honest assessment Compounds › Secretagogues & GH axis CJC-1295 ipamorelin tesamorelin needs a source On the subject in the title: Evidence quality in the secretagogue literature: an honest assessment Working notes rather than a conclusion. A follow-up question about Evidence quality that I did not know to…	+20	24	18k	4mo
Hair shedding at month three: mechanism and time course Practice › Side effects delayed gastric emptying fatigue constipation hair shedding On the subject in the title: Hair shedding at month three: mechanism and time course Working notes rather than a conclusion. Reading back through what has been written here about hair shedding, three…		2	47k	7mo
About the Syringes & needles category Devices › Syringes & needles syringe units dead volume needle gauge & length Pinned Wiki Insulin syringe graduations, dead volume, gauge and length selection, and reading units correctly. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	45k	1mo
"Should I double up?" — answered once, at length, calmly Practice › Administration subcutaneous injection missed dose injection site reaction "Should I double up?" — answered once, at length, calmly — setting out what I have, and where I think it stops being reliable. A practical question that I suspect has a boring answer, which is why I could not…	+24	28	13k	9mo
What the GIP component of tirzepatide is thought to contribute, and how confident we can be Compounds › Tirzepatide tirzepatide SURPASS programme SURMOUNT programme effect size Solved What the GIP component of tirzepatide is thought to contribute, and how confident we can be I have a specific reason for asking rather than idle curiosity, and the context is below. I would like to know what…	+16	20	23k	19h
Revisiting: Heart failure with preserved ejection fraction: symptom endpoints Clinical › Comorbidities chronic kidney disease blood pressure obstructive sleep apnoea On the subject in the title: Revisiting: Heart failure with preserved ejection fraction: symptom endpoints Working notes rather than a conclusion. Working notes on Heart failure with preserved ejection rather…	+4	8	43k	17mo
What a seizure notice actually says Sourcing › Logistics shipping packaging customs Solved What a seizure notice actually says I have a specific reason for asking rather than idle curiosity, and the context is below. The question about seizure notice that I actually want answered is the second one…	+36	40	568	17mo
What a certificate commits its issuer to — the long version Analytics › COA interpretation batch & lot numbers amino acid analysis reference standards certificate of analysis Asking directly, because I could not find a straight answer: What a certificate commits its issuer to — the long version A documentation question rather than an analytical one. I have a certificate in front…	+20	26	21k	2d
Gradient steepness and apparent purity: a worked comparison Analytics › HPLC & UHPLC data table UV & DAD detection peak integration HPLC On the subject in the title: Gradient steepness and apparent purity: a worked comparison Working notes rather than a conclusion. I have spent a fortnight trying to pin gradient steepness and apparent purity…		2	51k	22mo
Request declined, with reasoning — what changed since Meta › Feature requests wiki post site feedback translation Posting this under the heading it deserves: Request declined, with reasoning — what changed since Everything below is what sits behind that. What changes if the standard account of Request declined is wrong?…	+33	38	9.4k	2mo
Shoulders, tangent skims, and defensible integration — the long version Analytics › HPLC & UHPLC HPLC system suitability peak integration data table Shoulders, tangent skims, and defensible integration — the long version Writing it up because I had to work it out twice and would rather nobody else did. Setting out an integration problem with the actual…	+16	20	27k	3mo
Cagrilintide molecular characteristics and analytical considerations Compounds › Cagrilintide & amylin analogues cagrilintide randomised trial amylin analogues cagrisema Cagrilintide molecular characteristics and analytical considerations — setting out what I have, and where I think it stops being reliable. A methods question rather than a substantive one, about cagrilintide…		4	41k	12mo
Why cagrilintide alone is discussed so much less than in combination — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide effect size Solved Under review Why cagrilintide alone is discussed so much less than in combination — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Cagrilintide alone:…	+27	31	1.2k	22h
MHRA statements, read directly — the long version Regional › UK & Ireland MHRA cost per milligram personal import NHS On the subject in the title: MHRA statements, read directly — the long version Working notes rather than a conclusion. Asking about MHRA statements directly, because I have read four threads on it and each…		2	44k	22mo
Water content on a certificate and why it changes the arithmetic Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Closed Water content on a certificate and why it changes the arithmetic — setting out what I have, and where I think it stops being reliable. Water content: setting out the arithmetic in full, because I have had to…	+19	23	24k	14mo
Recording a dissent on a document rather than suppressing it Documentation › Doc review maintainership promoted to docs citation check Solved Recording a dissent on a document rather than suppressing it Writing it up because I had to work it out twice and would rather nobody else did. Recording a dissent, and specifically the version of it that the…	+15	19	25k	1mo