Ranked by engagement

Top topics — this week page 10

Ranked by replies, likes and views over this week, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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314 topics · page 10 of 11

Topic	Participants	Replies	Views	Activity
Second pass at: Reading a trial's population section before its results Evidence › Trials open label intention to treat estimand surrogate endpoints Solved Second pass at: Reading a trial's population section before its results Writing it up because I had to work it out twice and would rather nobody else did. Reading STEP 1 ( N Engl J Med , 2021) for the…		4	9.5k	10h
Irish differences from the UK position — what changed since Regional › UK & Ireland personal import cost per milligram NHS Irish differences from the UK position — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Irish differences is wrong? I ask…	+8	12	782	1d
About the Announcements category Meta › Announcements guidelines trust levels moderation Pinned Wiki Staff announcements, policy changes, and scheduled maintenance. Read-only except for questions. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with…	+3	7	8.7k	4h
German, French and Dutch differences, compared Regional › European Union cost per milligram formulary EMA German, French and Dutch differences, compared — setting out what I have, and where I think it stops being reliable. Asking about german directly, because I have read four threads on it and each answered a…		2	12k	10h
What a statistical analysis plan adds that the paper does not Evidence › Trials open label discontinuation & dropout randomised trial surrogate endpoints Solved What a statistical analysis plan adds that the paper does not — that is the question, and I have not found it answered plainly anywhere I have looked. Statistical analysis plan, and specifically the version…		2	6.6k	10h
eGFR fluctuation and the creatinine denominator problem Clinical › Bloodwork eGFR & renal function liver enzymes lipid panel On the subject in the title: eGFR fluctuation and the creatinine denominator problem Working notes rather than a conclusion. Proposing that egfr fluctuation deserves a maintained page rather than a recurring…		2	10k	6d
System suitability injections: if they failed, the run did not happen — the long version Analytics › HPLC & UHPLC gradient method UV & DAD detection system suitability peak integration System suitability injections: if they failed, the run did not happen — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about System suitability…	+2	6	6.2k	1d
About the Independent verification category Sourcing › Independent verification Janoshik Analytical Medutest PeptideMeter Pinned Wiki Janoshik, Medutest, PeptideMeter and VendorInvestigate results, how to submit a sample, and how to read what comes back. This post is a community wiki: any member at trust level 3 or above can edit it, and…	+1	5	5.8k	23h
Journal club: STEP 1 and the treatment-policy estimand Evidence › Journal club journal club randomised trial number needed to treat risk of bias Journal club: STEP 1 and the treatment-policy estimand Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 1 ( N Engl J Med , 2021). Please read it before…		3	11k	9h
Isotope patterns and why the monoisotopic peak is not the tallest — does this still hold? Analytics › Mass spectrometry charge states counter-ion content high-resolution MS mass error (ppm) Solved Isotope patterns and why the monoisotopic peak is not the tallest — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Asking about Isotope patterns…		2	4.6k	7h
[2026 update] Second opinions: how to seek one without burning the first Clinical › Prescriber conversations prior authorisation beginner friendly type 2 diabetes Solved On the subject in the title: Second opinions: how to seek one without burning the first Working notes rather than a conclusion. Two things I would like separated before anyone answers on Second opinions,…		2	5.9k	1d
Blinding yourself: practical methods and their limits — the long version Research Methods › N-of-1 designs worked example effect size confounding data table Blinding yourself: practical methods and their limits — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Blinding yourself,…	+7	11	1.8k	22h
The SOUL trial and oral semaglutide cardiovascular outcomes Compounds › Oral incretins orforglipron oral semaglutide SOUL trial PIONEER programme Posting this under the heading it deserves: The SOUL trial and oral semaglutide cardiovascular outcomes Everything below is what sits behind that. Collecting what is known about SOUL trial and oral…		2	7.1k	9h
About the Hydration & electrolytes category Nutrition & Training › Hydration & electrolytes fatigue blood pressure heart rate Pinned Wiki Fluid intake, sodium, potassium and magnesium, and the very ordinary causes of week-two malaise. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded…		4	3.6k	18h
How the vendor documentation pages are maintained, and by whom Sourcing › Vendor reports certificate of analysis Janoshik Analytical batch & lot numbers documentation quality Solved How the vendor documentation pages are maintained, and by whom I have a specific reason for asking rather than idle curiosity, and the context is below. Vendor documentation pages keeps being re-asked here…		2	6k	4h
[2026 update] Why 99.2% and 97.8% on the same lot can both be correct Analytics › HPLC & UHPLC UV & DAD detection system suitability peak integration gradient method Solved Why 99.2% and 97.8% on the same lot can both be correct — that is the question, and I have not found it answered plainly anywhere I have looked. I would like to understand what this number means before I…	+1	5	719	2d
What TRIUMPH is designed to answer, and why we should not pre-empt it Compounds › Retatrutide retatrutide effect size TRIUMPH programme preprint Solved What TRIUMPH is designed to answer, and why we should not pre-empt it I have a specific reason for asking rather than idle curiosity, and the context is below. TRIUMPH keeps being re-asked here and I think…	+4	8	142	6h
Revisiting: Spike-and-recover accuracy for a peptide assay Analytics › Method validation LOD & LOQ system suitability stability-indicating method linearity Revisiting: Spike-and-recover accuracy for a peptide assay — setting out what I have, and where I think it stops being reliable. I was wrong about Spike-and-recover accuracy in a thread last spring and I…		2	6.8k	21h
SURPASS-2 and the comparator dose question that will not go away — what changed since Compounds › Tirzepatide SURMOUNT programme tirzepatide effect size Posting this under the heading it deserves: SURPASS-2 and the comparator dose question that will not go away — what changed since Everything below is what sits behind that. What changes if the standard…	+2	6	5.5k	7h
MS/MS sequence confirmation: what it costs and when it is worth it Analytics › Mass spectrometry LC-MS MALDI-TOF charge states Solved Pinned MS/MS sequence confirmation: what it costs and when it is worth it — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+2	6	2.7k	1d
Type 1 diabetes: off-label use and the evidence gap Clinical › Special populations pregnancy & planning bariatric surgery history disordered eating Solved On the subject in the title: Type 1 diabetes: off-label use and the evidence gap Working notes rather than a conclusion. Type 1 diabetes, and specifically the version of it that the documentation does not…		2	2.3k	1d
A community side-effect dataset, with its response rate and biases Data & Tools › Datasets confounding site feedback data table observational data Solved A community side-effect dataset, with its response rate and biases — setting out what I have, and where I think it stops being reliable. Community side-effect dataset: setting out the arithmetic in full,…		2	5.1k	19h
Coming back to: When a red flag was a misunderstanding, and the retraction Sourcing › Red flags mislabelling moderation documentation quality When a red flag was a misunderstanding, and the retraction I have a specific reason for asking rather than idle curiosity, and the context is below. Red flag — I have the observation and I do not trust my…	+6	10	257	21h
Drawing up with one needle and injecting with another Practice › Administration injection site rotation missed dose aseptic technique subcutaneous injection On the subject in the title: Drawing up with one needle and injecting with another Working notes rather than a conclusion. A question about technique rather than about dose. I have been doing the same thing…	+1	5	6.9k	1d
Why a pen's dose steps are fixed and what that costs you Devices › Pens & autoinjectors dead volume storage subcutaneous injection missed dose Solved The question in the title: Why a pen's dose steps are fixed and what that costs you I will give what I have already checked below so nobody repeats it. A question about a device rather than about a compound,…		4	2.5k	23h
Chain of custody for a sample you posted yourself Sourcing › Independent verification PeptideMeter third-party testing Janoshik Analytical blind sampling Chain of custody for a sample you posted yourself Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about chain of custody in a thread last spring and I would like…		2	7.3k	5h
Coming back to: Storing in the door of the fridge is worse than you think Practice › Storage & stability temperature excursion cold chain cloudy or discoloured solution Wiki On the subject in the title: Storing in the door of the fridge is worse than you think Working notes rather than a conclusion. Asking about the failure mode rather than the procedure, because the procedure is…	+2	6	2.1k	1d
PCOS and metabolic overlap: what is and is not studied Clinical › Comorbidities chronic kidney disease MASH / hepatic steatosis obstructive sleep apnoea type 2 diabetes On the subject in the title: PCOS and metabolic overlap: what is and is not studied Working notes rather than a conclusion. PCOS and metabolic overlap, from the point of view of someone who has read the…		3	6.6k	1d
How to ask about something you suspect is a bad idea — a second dataset Start Here › How to Ask beginner friendly onboarding site feedback Solved How to ask about something you suspect is a bad idea — a second dataset — that is the question, and I have not found it answered plainly anywhere I have looked. Counting it rather than describing it, because…		2	3.3k	4h
Follow-up: Patterns that reliably precede a problem, documented Sourcing › Red flags underdosing disputed documentation quality Solved On the subject in the title: Patterns that reliably precede a problem, documented Working notes rather than a conclusion. A follow-up question about Patterns that I did not know to ask the first time. The…		2	70	1d